Less is more: Antibiotics at the beginning of life

Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver fo...

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Detalles Bibliográficos
Autores principales: Stocker, Martin, Klingenberg, Claus, Navér, Lars, Nordberg, Viveka, Berardi, Alberto, el Helou, Salhab, Fusch, Gerhard, Bliss, Joseph M., Lehnick, Dirk, Dimopoulou, Varvara, Guerina, Nicholas, Seliga-Siwecka, Joanna, Maton, Pierre, Lagae, Donatienne, Mari, Judit, Janota, Jan, Agyeman, Philipp K. A., Pfister, Riccardo, Latorre, Giuseppe, Maffei, Gianfranco, Laforgia, Nichola, Mózes, Enikő, Størdal, Ketil, Strunk, Tobias, Giannoni, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134707/
https://www.ncbi.nlm.nih.gov/pubmed/37105958
http://dx.doi.org/10.1038/s41467-023-38156-7
Descripción
Sumario:Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise (a random scatter) affect the decision-making process. In this perspective, we advocate for a factual approach quantifying the burden of treatment in relation to the burden of disease balancing antimicrobial stewardship and effective sepsis management.

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