Less is more: Antibiotics at the beginning of life

Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver fo...

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Autores principales: Stocker, Martin, Klingenberg, Claus, Navér, Lars, Nordberg, Viveka, Berardi, Alberto, el Helou, Salhab, Fusch, Gerhard, Bliss, Joseph M., Lehnick, Dirk, Dimopoulou, Varvara, Guerina, Nicholas, Seliga-Siwecka, Joanna, Maton, Pierre, Lagae, Donatienne, Mari, Judit, Janota, Jan, Agyeman, Philipp K. A., Pfister, Riccardo, Latorre, Giuseppe, Maffei, Gianfranco, Laforgia, Nichola, Mózes, Enikő, Størdal, Ketil, Strunk, Tobias, Giannoni, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134707/
https://www.ncbi.nlm.nih.gov/pubmed/37105958
http://dx.doi.org/10.1038/s41467-023-38156-7
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author Stocker, Martin
Klingenberg, Claus
Navér, Lars
Nordberg, Viveka
Berardi, Alberto
el Helou, Salhab
Fusch, Gerhard
Bliss, Joseph M.
Lehnick, Dirk
Dimopoulou, Varvara
Guerina, Nicholas
Seliga-Siwecka, Joanna
Maton, Pierre
Lagae, Donatienne
Mari, Judit
Janota, Jan
Agyeman, Philipp K. A.
Pfister, Riccardo
Latorre, Giuseppe
Maffei, Gianfranco
Laforgia, Nichola
Mózes, Enikő
Størdal, Ketil
Strunk, Tobias
Giannoni, Eric
author_facet Stocker, Martin
Klingenberg, Claus
Navér, Lars
Nordberg, Viveka
Berardi, Alberto
el Helou, Salhab
Fusch, Gerhard
Bliss, Joseph M.
Lehnick, Dirk
Dimopoulou, Varvara
Guerina, Nicholas
Seliga-Siwecka, Joanna
Maton, Pierre
Lagae, Donatienne
Mari, Judit
Janota, Jan
Agyeman, Philipp K. A.
Pfister, Riccardo
Latorre, Giuseppe
Maffei, Gianfranco
Laforgia, Nichola
Mózes, Enikő
Størdal, Ketil
Strunk, Tobias
Giannoni, Eric
author_sort Stocker, Martin
collection PubMed
description Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise (a random scatter) affect the decision-making process. In this perspective, we advocate for a factual approach quantifying the burden of treatment in relation to the burden of disease balancing antimicrobial stewardship and effective sepsis management.
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spelling pubmed-101347072023-04-28 Less is more: Antibiotics at the beginning of life Stocker, Martin Klingenberg, Claus Navér, Lars Nordberg, Viveka Berardi, Alberto el Helou, Salhab Fusch, Gerhard Bliss, Joseph M. Lehnick, Dirk Dimopoulou, Varvara Guerina, Nicholas Seliga-Siwecka, Joanna Maton, Pierre Lagae, Donatienne Mari, Judit Janota, Jan Agyeman, Philipp K. A. Pfister, Riccardo Latorre, Giuseppe Maffei, Gianfranco Laforgia, Nichola Mózes, Enikő Størdal, Ketil Strunk, Tobias Giannoni, Eric Nat Commun Perspective Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance and perturbations of the developing microbiome. Early-life microbiome disruption increases the risks of developing chronic diseases later in life. Fear of missing evolving neonatal sepsis is the key driver for antibiotic overtreatment early in life. Bias (a systemic deviation towards overtreatment) and noise (a random scatter) affect the decision-making process. In this perspective, we advocate for a factual approach quantifying the burden of treatment in relation to the burden of disease balancing antimicrobial stewardship and effective sepsis management. Nature Publishing Group UK 2023-04-27 /pmc/articles/PMC10134707/ /pubmed/37105958 http://dx.doi.org/10.1038/s41467-023-38156-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Stocker, Martin
Klingenberg, Claus
Navér, Lars
Nordberg, Viveka
Berardi, Alberto
el Helou, Salhab
Fusch, Gerhard
Bliss, Joseph M.
Lehnick, Dirk
Dimopoulou, Varvara
Guerina, Nicholas
Seliga-Siwecka, Joanna
Maton, Pierre
Lagae, Donatienne
Mari, Judit
Janota, Jan
Agyeman, Philipp K. A.
Pfister, Riccardo
Latorre, Giuseppe
Maffei, Gianfranco
Laforgia, Nichola
Mózes, Enikő
Størdal, Ketil
Strunk, Tobias
Giannoni, Eric
Less is more: Antibiotics at the beginning of life
title Less is more: Antibiotics at the beginning of life
title_full Less is more: Antibiotics at the beginning of life
title_fullStr Less is more: Antibiotics at the beginning of life
title_full_unstemmed Less is more: Antibiotics at the beginning of life
title_short Less is more: Antibiotics at the beginning of life
title_sort less is more: antibiotics at the beginning of life
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134707/
https://www.ncbi.nlm.nih.gov/pubmed/37105958
http://dx.doi.org/10.1038/s41467-023-38156-7
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