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A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses
When humans experience a new, devastating viral infection such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), significant challenges arise. How should individuals as well as societies respond to the situation? One of the primary questions concerns the origin of the SARS-CoV-2 virus...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134824/ https://www.ncbi.nlm.nih.gov/pubmed/36897089 http://dx.doi.org/10.1128/jvi.00365-23 |
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author | Alwine, James C. Casadevall, Arturo Enquist, Lynn W. Goodrum, Felicia D. Imperiale, Michael J. |
author_facet | Alwine, James C. Casadevall, Arturo Enquist, Lynn W. Goodrum, Felicia D. Imperiale, Michael J. |
author_sort | Alwine, James C. |
collection | PubMed |
description | When humans experience a new, devastating viral infection such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), significant challenges arise. How should individuals as well as societies respond to the situation? One of the primary questions concerns the origin of the SARS-CoV-2 virus that infected and was transmitted efficiently among humans, resulting in a pandemic. At first glance, the question appears straightforward to answer. However, the origin of SARS-CoV-2 has been the topic of substantial debate primarily because we do not have access to some relevant data. At least two major hypotheses have been suggested: a natural origin through zoonosis followed by sustained human-to-human spread or the introduction of a natural virus into humans from a laboratory source. Here, we summarize the scientific evidence that informs this debate to provide our fellow scientists and the public with the tools to join the discussion in a constructive and informed manner. Our goal is to dissect the evidence to make it more accessible to those interested in this important problem. The engagement of a broad representation of scientists is critical to ensure that the public and policy-makers can draw on relevant expertise in navigating this controversy. |
format | Online Article Text |
id | pubmed-10134824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-101348242023-04-28 A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses Alwine, James C. Casadevall, Arturo Enquist, Lynn W. Goodrum, Felicia D. Imperiale, Michael J. J Virol Editorial When humans experience a new, devastating viral infection such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), significant challenges arise. How should individuals as well as societies respond to the situation? One of the primary questions concerns the origin of the SARS-CoV-2 virus that infected and was transmitted efficiently among humans, resulting in a pandemic. At first glance, the question appears straightforward to answer. However, the origin of SARS-CoV-2 has been the topic of substantial debate primarily because we do not have access to some relevant data. At least two major hypotheses have been suggested: a natural origin through zoonosis followed by sustained human-to-human spread or the introduction of a natural virus into humans from a laboratory source. Here, we summarize the scientific evidence that informs this debate to provide our fellow scientists and the public with the tools to join the discussion in a constructive and informed manner. Our goal is to dissect the evidence to make it more accessible to those interested in this important problem. The engagement of a broad representation of scientists is critical to ensure that the public and policy-makers can draw on relevant expertise in navigating this controversy. American Society for Microbiology 2023-03-28 /pmc/articles/PMC10134824/ /pubmed/36897089 http://dx.doi.org/10.1128/jvi.00365-23 Text en Copyright © 2023 Alwine et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Editorial Alwine, James C. Casadevall, Arturo Enquist, Lynn W. Goodrum, Felicia D. Imperiale, Michael J. A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses |
title | A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses |
title_full | A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses |
title_fullStr | A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses |
title_full_unstemmed | A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses |
title_short | A Critical Analysis of the Evidence for the SARS-CoV-2 Origin Hypotheses |
title_sort | critical analysis of the evidence for the sars-cov-2 origin hypotheses |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134824/ https://www.ncbi.nlm.nih.gov/pubmed/36897089 http://dx.doi.org/10.1128/jvi.00365-23 |
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