ClC-3 regulates the excitability of nociceptive neurons and is involved in inflammatory processes within the spinal sensory pathway

ClC-3 Cl(–)/H(+) exchangers are expressed in multiple endosomal compartments and likely modify intra-endosomal pH and [Cl(–)] via the stoichiometrically coupled exchange of two Cl(–) ions and one H(+). We studied pain perception in Clcn3(–/–) mice and found that ClC-3 not only modifies the electrica...

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Detalles Bibliográficos
Autores principales: Sierra-Marquez, Juan, Willuweit, Antje, Schöneck, Michael, Bungert-Plümke, Stefanie, Gehlen, Jana, Balduin, Carina, Müller, Frank, Lampert, Angelika, Fahlke, Christoph, Guzman, Raul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134905/
https://www.ncbi.nlm.nih.gov/pubmed/37124866
http://dx.doi.org/10.3389/fncel.2022.920075

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