Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities. Firstly, all target isatins were examined for in vitro antitumor action on NCI-USA panel (58 tumour cell lines). The...

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Detalles Bibliográficos
Autores principales: Shaldam, Moataz A., Almahli, Hadia, Angeli, Andrea, Badi, Rehab Mustafa, Khaleel, Eman F., Zain-Alabdeen, Abdelrahman I., Elsayed, Zainab M., Elkaeed, Eslam B., Salem, Rofaida, Supuran, Claudiu T., Eldehna, Wagdy M., Tawfik, Haytham O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134960/
https://www.ncbi.nlm.nih.gov/pubmed/37122176
http://dx.doi.org/10.1080/14756366.2023.2203389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134960/
https://www.ncbi.nlm.nih.gov/pubmed/37122176
http://dx.doi.org/10.1080/14756366.2023.2203389

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