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Evaluation of Implementation and Effectiveness of China’s Antibiotic Stewardship in the First Affiliated Hospital of Sun Yat-sen University

Antibiotic stewardship has been prioritized by governments and health care organizations in recent years as antibiotic resistance is markedly increasing. A tertiary hospital in Guangzhou, China was chosen as a study example to undertake an implementation and effectiveness evaluation of China’s antib...

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Autores principales: Zheng, Nianzhen, Li, Jian, Liu, Yang, Liao, Kang, Chen, Jie, Zhang, Chengcheng, Wen, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135032/
https://www.ncbi.nlm.nih.gov/pubmed/37107132
http://dx.doi.org/10.3390/antibiotics12040770
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author Zheng, Nianzhen
Li, Jian
Liu, Yang
Liao, Kang
Chen, Jie
Zhang, Chengcheng
Wen, Weiping
author_facet Zheng, Nianzhen
Li, Jian
Liu, Yang
Liao, Kang
Chen, Jie
Zhang, Chengcheng
Wen, Weiping
author_sort Zheng, Nianzhen
collection PubMed
description Antibiotic stewardship has been prioritized by governments and health care organizations in recent years as antibiotic resistance is markedly increasing. A tertiary hospital in Guangzhou, China was chosen as a study example to undertake an implementation and effectiveness evaluation of China’s antibiotic stewardship to improve and promote antimicrobial stewardship nationwide. The general surgery department of the study hospital was utilized to examine surgical site infection, and samples from across the hospital were used to identify bloodstream infection. Data was analyzed using descriptive analysis, the Mann–Kendall trend test, logit model and panel data model, and t-tests. In terms of prophylactic and therapeutic antibiotic rational use, respectively, we evaluated implementation conditions, the correlation between implementation and corresponding disease progress, and the cost-effectiveness of China’s antibiotic stewardship. For perioperative prophylactic antibiotic use, antibiotic stewardship was found to have been well-implemented, cost-effective, and reduced the incidence of surgical site infection. However, concerning therapeutic use and antibiotic-resistant bacterial infection prophylaxis, the complexity of influencing factors and the contradiction between stewardship implementation and clinical demand needs to be further evaluated.
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spelling pubmed-101350322023-04-28 Evaluation of Implementation and Effectiveness of China’s Antibiotic Stewardship in the First Affiliated Hospital of Sun Yat-sen University Zheng, Nianzhen Li, Jian Liu, Yang Liao, Kang Chen, Jie Zhang, Chengcheng Wen, Weiping Antibiotics (Basel) Article Antibiotic stewardship has been prioritized by governments and health care organizations in recent years as antibiotic resistance is markedly increasing. A tertiary hospital in Guangzhou, China was chosen as a study example to undertake an implementation and effectiveness evaluation of China’s antibiotic stewardship to improve and promote antimicrobial stewardship nationwide. The general surgery department of the study hospital was utilized to examine surgical site infection, and samples from across the hospital were used to identify bloodstream infection. Data was analyzed using descriptive analysis, the Mann–Kendall trend test, logit model and panel data model, and t-tests. In terms of prophylactic and therapeutic antibiotic rational use, respectively, we evaluated implementation conditions, the correlation between implementation and corresponding disease progress, and the cost-effectiveness of China’s antibiotic stewardship. For perioperative prophylactic antibiotic use, antibiotic stewardship was found to have been well-implemented, cost-effective, and reduced the incidence of surgical site infection. However, concerning therapeutic use and antibiotic-resistant bacterial infection prophylaxis, the complexity of influencing factors and the contradiction between stewardship implementation and clinical demand needs to be further evaluated. MDPI 2023-04-17 /pmc/articles/PMC10135032/ /pubmed/37107132 http://dx.doi.org/10.3390/antibiotics12040770 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zheng, Nianzhen
Li, Jian
Liu, Yang
Liao, Kang
Chen, Jie
Zhang, Chengcheng
Wen, Weiping
Evaluation of Implementation and Effectiveness of China’s Antibiotic Stewardship in the First Affiliated Hospital of Sun Yat-sen University
title Evaluation of Implementation and Effectiveness of China’s Antibiotic Stewardship in the First Affiliated Hospital of Sun Yat-sen University
title_full Evaluation of Implementation and Effectiveness of China’s Antibiotic Stewardship in the First Affiliated Hospital of Sun Yat-sen University
title_fullStr Evaluation of Implementation and Effectiveness of China’s Antibiotic Stewardship in the First Affiliated Hospital of Sun Yat-sen University
title_full_unstemmed Evaluation of Implementation and Effectiveness of China’s Antibiotic Stewardship in the First Affiliated Hospital of Sun Yat-sen University
title_short Evaluation of Implementation and Effectiveness of China’s Antibiotic Stewardship in the First Affiliated Hospital of Sun Yat-sen University
title_sort evaluation of implementation and effectiveness of china’s antibiotic stewardship in the first affiliated hospital of sun yat-sen university
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135032/
https://www.ncbi.nlm.nih.gov/pubmed/37107132
http://dx.doi.org/10.3390/antibiotics12040770
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