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Epidemiology and Risk Factors of Carbapenemase-Producing Enterobacteriaceae Acquisition and Colonization at a Korean Hospital over 1 Year

Background: Carbapenemase-producing Enterobacteriaceae (CPE) are known to be primarily responsible for the increasing spread of carbapenem-resistant Enterobacteriaceae and have therefore been targeted for preventing transmission and appropriate treatment. This study aimed to describe the clinical an...

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Autores principales: Kim, Hye-Jin, Hyun, JungHee, Jeong, Hyo-Seon, Lee, Yeon-Kyeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135040/
https://www.ncbi.nlm.nih.gov/pubmed/37107121
http://dx.doi.org/10.3390/antibiotics12040759
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author Kim, Hye-Jin
Hyun, JungHee
Jeong, Hyo-Seon
Lee, Yeon-Kyeng
author_facet Kim, Hye-Jin
Hyun, JungHee
Jeong, Hyo-Seon
Lee, Yeon-Kyeng
author_sort Kim, Hye-Jin
collection PubMed
description Background: Carbapenemase-producing Enterobacteriaceae (CPE) are known to be primarily responsible for the increasing spread of carbapenem-resistant Enterobacteriaceae and have therefore been targeted for preventing transmission and appropriate treatment. This study aimed to describe the clinical and epidemiological characteristics and risk factors of CPE infection in terms of acquisition and colonization. Methods: We examined patients’ hospital data, including active screening on patients’ admission and in intensive care units (ICUs). We identified risk factors for CPE acquisition by comparing the clinical and epidemiological data of CPE-positive patients between colonization and acquisition groups. Results: A total of 77 CPE patients were included (51 colonized and 26 acquired). The most frequent Enterobacteriaceae species was Klebsiella pneumoniae. Among CPE-colonized patients, 80.4% had a hospitalization history within 3 months. CPE acquisition was significantly associated with treatment in an ICU [adjusted odds ratio (aOR): 46.72, 95% confidence interval (CI): 5.08–430.09] and holding a gastrointestinal tube (aOR: 12.70, 95% CI: 2.61–61.84). Conclusions: CPE acquisition was significantly associated with ICU stay, open wounds, holding catheters or tubes, and antibiotic treatment. Active CPE screening should be implemented on admission and periodically for high-risk patients.
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spelling pubmed-101350402023-04-28 Epidemiology and Risk Factors of Carbapenemase-Producing Enterobacteriaceae Acquisition and Colonization at a Korean Hospital over 1 Year Kim, Hye-Jin Hyun, JungHee Jeong, Hyo-Seon Lee, Yeon-Kyeng Antibiotics (Basel) Brief Report Background: Carbapenemase-producing Enterobacteriaceae (CPE) are known to be primarily responsible for the increasing spread of carbapenem-resistant Enterobacteriaceae and have therefore been targeted for preventing transmission and appropriate treatment. This study aimed to describe the clinical and epidemiological characteristics and risk factors of CPE infection in terms of acquisition and colonization. Methods: We examined patients’ hospital data, including active screening on patients’ admission and in intensive care units (ICUs). We identified risk factors for CPE acquisition by comparing the clinical and epidemiological data of CPE-positive patients between colonization and acquisition groups. Results: A total of 77 CPE patients were included (51 colonized and 26 acquired). The most frequent Enterobacteriaceae species was Klebsiella pneumoniae. Among CPE-colonized patients, 80.4% had a hospitalization history within 3 months. CPE acquisition was significantly associated with treatment in an ICU [adjusted odds ratio (aOR): 46.72, 95% confidence interval (CI): 5.08–430.09] and holding a gastrointestinal tube (aOR: 12.70, 95% CI: 2.61–61.84). Conclusions: CPE acquisition was significantly associated with ICU stay, open wounds, holding catheters or tubes, and antibiotic treatment. Active CPE screening should be implemented on admission and periodically for high-risk patients. MDPI 2023-04-14 /pmc/articles/PMC10135040/ /pubmed/37107121 http://dx.doi.org/10.3390/antibiotics12040759 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Kim, Hye-Jin
Hyun, JungHee
Jeong, Hyo-Seon
Lee, Yeon-Kyeng
Epidemiology and Risk Factors of Carbapenemase-Producing Enterobacteriaceae Acquisition and Colonization at a Korean Hospital over 1 Year
title Epidemiology and Risk Factors of Carbapenemase-Producing Enterobacteriaceae Acquisition and Colonization at a Korean Hospital over 1 Year
title_full Epidemiology and Risk Factors of Carbapenemase-Producing Enterobacteriaceae Acquisition and Colonization at a Korean Hospital over 1 Year
title_fullStr Epidemiology and Risk Factors of Carbapenemase-Producing Enterobacteriaceae Acquisition and Colonization at a Korean Hospital over 1 Year
title_full_unstemmed Epidemiology and Risk Factors of Carbapenemase-Producing Enterobacteriaceae Acquisition and Colonization at a Korean Hospital over 1 Year
title_short Epidemiology and Risk Factors of Carbapenemase-Producing Enterobacteriaceae Acquisition and Colonization at a Korean Hospital over 1 Year
title_sort epidemiology and risk factors of carbapenemase-producing enterobacteriaceae acquisition and colonization at a korean hospital over 1 year
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135040/
https://www.ncbi.nlm.nih.gov/pubmed/37107121
http://dx.doi.org/10.3390/antibiotics12040759
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