Physiologically-Based Pharmacokinetic Modelling to Predict the Pharmacokinetics and Pharmacodynamics of Linezolid in Adults and Children with Tuberculous Meningitis

Linezolid is used off-label for treatment of central nervous system infections. However, its pharmacokinetics and target attainment in cranial cerebrospinal fluid (CSF) in tuberculous meningitis patients is unknown. This study aimed to predict linezolid cranial CSF concentrations and assess attainme...

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Detalles Bibliográficos
Autores principales: Litjens, Carlijn H. C., Verscheijden, Laurens F. M., Svensson, Elin M., van den Broek, Petra H. H., van Hove, Hedwig, Koenderink, Jan B., Russel, Frans G. M., Aarnoutse, Rob E., te Brake, Lindsey H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135070/
https://www.ncbi.nlm.nih.gov/pubmed/37107064
http://dx.doi.org/10.3390/antibiotics12040702

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