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Distribution of Causative Microorganisms in Diabetic Foot Infections: A Ten-Year Retrospective Study in a Tertiary Care Hospital in Central Malaysia

Diabetes mellitus is a global pandemic, especially in Southeast Asia. Diabetic foot infection (DFI) is a common complication of this condition and causes significant morbidity and mortality in those affected. There is a lack of locally published data on the types of microorganisms and empirical anti...

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Autores principales: Hadi, Parichehr, Rampal, Sanjiv, Neela, Vasantha Kumari, Cheema, Manraj Singh, Sarawan Singh, Sandeep Singh, Kee Tan, Eng, Sinniah, Ajantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135124/
https://www.ncbi.nlm.nih.gov/pubmed/37107049
http://dx.doi.org/10.3390/antibiotics12040687
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author Hadi, Parichehr
Rampal, Sanjiv
Neela, Vasantha Kumari
Cheema, Manraj Singh
Sarawan Singh, Sandeep Singh
Kee Tan, Eng
Sinniah, Ajantha
author_facet Hadi, Parichehr
Rampal, Sanjiv
Neela, Vasantha Kumari
Cheema, Manraj Singh
Sarawan Singh, Sandeep Singh
Kee Tan, Eng
Sinniah, Ajantha
author_sort Hadi, Parichehr
collection PubMed
description Diabetes mellitus is a global pandemic, especially in Southeast Asia. Diabetic foot infection (DFI) is a common complication of this condition and causes significant morbidity and mortality in those affected. There is a lack of locally published data on the types of microorganisms and empirical antibiotics being prescribed. This paper highlights the importance of local microorganism culture and antibiotic prescription trends among diabetic foot patients in a tertiary care hospital in central Malaysia. This is a retrospective, cross-sectional study of data taken from January 2010 to December 2019 among 434 patients admitted with diabetic foot infections (DFIs) using the Wagner classification. Patients between the ages of 58 and 68 years old had the highest rate of infection. Pseudomonas Aeruginosa, Proteus spp., and Proteus mirabilis appeared to be the most isolated Gram-negative microorganisms, and Staphylococcus aureus, Streptococcus agalactiae, and MRSA appeared to be the most common Gram-positive microorganisms. The most common empirical antibiotics prescribed were ampicillin/sulbactam, followed by ciprofloxacin and ceftazidime, and the most common therapeutic antibiotics prescribed were ampicillin/sulbactam, ciprofloxacin, and cefuroxime. This study could be immensely pertinent in facilitating future empirical therapy guidelines for treating diabetic foot infections.
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spelling pubmed-101351242023-04-28 Distribution of Causative Microorganisms in Diabetic Foot Infections: A Ten-Year Retrospective Study in a Tertiary Care Hospital in Central Malaysia Hadi, Parichehr Rampal, Sanjiv Neela, Vasantha Kumari Cheema, Manraj Singh Sarawan Singh, Sandeep Singh Kee Tan, Eng Sinniah, Ajantha Antibiotics (Basel) Article Diabetes mellitus is a global pandemic, especially in Southeast Asia. Diabetic foot infection (DFI) is a common complication of this condition and causes significant morbidity and mortality in those affected. There is a lack of locally published data on the types of microorganisms and empirical antibiotics being prescribed. This paper highlights the importance of local microorganism culture and antibiotic prescription trends among diabetic foot patients in a tertiary care hospital in central Malaysia. This is a retrospective, cross-sectional study of data taken from January 2010 to December 2019 among 434 patients admitted with diabetic foot infections (DFIs) using the Wagner classification. Patients between the ages of 58 and 68 years old had the highest rate of infection. Pseudomonas Aeruginosa, Proteus spp., and Proteus mirabilis appeared to be the most isolated Gram-negative microorganisms, and Staphylococcus aureus, Streptococcus agalactiae, and MRSA appeared to be the most common Gram-positive microorganisms. The most common empirical antibiotics prescribed were ampicillin/sulbactam, followed by ciprofloxacin and ceftazidime, and the most common therapeutic antibiotics prescribed were ampicillin/sulbactam, ciprofloxacin, and cefuroxime. This study could be immensely pertinent in facilitating future empirical therapy guidelines for treating diabetic foot infections. MDPI 2023-03-31 /pmc/articles/PMC10135124/ /pubmed/37107049 http://dx.doi.org/10.3390/antibiotics12040687 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hadi, Parichehr
Rampal, Sanjiv
Neela, Vasantha Kumari
Cheema, Manraj Singh
Sarawan Singh, Sandeep Singh
Kee Tan, Eng
Sinniah, Ajantha
Distribution of Causative Microorganisms in Diabetic Foot Infections: A Ten-Year Retrospective Study in a Tertiary Care Hospital in Central Malaysia
title Distribution of Causative Microorganisms in Diabetic Foot Infections: A Ten-Year Retrospective Study in a Tertiary Care Hospital in Central Malaysia
title_full Distribution of Causative Microorganisms in Diabetic Foot Infections: A Ten-Year Retrospective Study in a Tertiary Care Hospital in Central Malaysia
title_fullStr Distribution of Causative Microorganisms in Diabetic Foot Infections: A Ten-Year Retrospective Study in a Tertiary Care Hospital in Central Malaysia
title_full_unstemmed Distribution of Causative Microorganisms in Diabetic Foot Infections: A Ten-Year Retrospective Study in a Tertiary Care Hospital in Central Malaysia
title_short Distribution of Causative Microorganisms in Diabetic Foot Infections: A Ten-Year Retrospective Study in a Tertiary Care Hospital in Central Malaysia
title_sort distribution of causative microorganisms in diabetic foot infections: a ten-year retrospective study in a tertiary care hospital in central malaysia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135124/
https://www.ncbi.nlm.nih.gov/pubmed/37107049
http://dx.doi.org/10.3390/antibiotics12040687
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