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Staphylococcus capitis: Review of Its Role in Infections and Outbreaks

In June 2021, a national incident team was formed due to an increased detection of Staphylococcus capitis in samples from hospitalised infants. Staphylococcus capitis has been known to cause outbreaks in neonatal units across the globe, but the extent of the UK spread was unclear. A literature revie...

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Autores principales: Heath, Victoria, Cloutman-Green, Elaine, Watkin, Samuel, Karlikowska, Magdalena, Ready, Derren, Hatcher, James, Pearce-Smith, Nicola, Brown, Colin, Demirjian, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135222/
https://www.ncbi.nlm.nih.gov/pubmed/37107031
http://dx.doi.org/10.3390/antibiotics12040669
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author Heath, Victoria
Cloutman-Green, Elaine
Watkin, Samuel
Karlikowska, Magdalena
Ready, Derren
Hatcher, James
Pearce-Smith, Nicola
Brown, Colin
Demirjian, Alicia
author_facet Heath, Victoria
Cloutman-Green, Elaine
Watkin, Samuel
Karlikowska, Magdalena
Ready, Derren
Hatcher, James
Pearce-Smith, Nicola
Brown, Colin
Demirjian, Alicia
author_sort Heath, Victoria
collection PubMed
description In June 2021, a national incident team was formed due to an increased detection of Staphylococcus capitis in samples from hospitalised infants. Staphylococcus capitis has been known to cause outbreaks in neonatal units across the globe, but the extent of the UK spread was unclear. A literature review was undertaken to support case identification, clinical management and environmental infection control. A literature search was undertaken on multiple databases from inception to 24 May 2021, using keywords such as “Staphylococcus capitis”, “NRCS-A”, “S. capitis”, “neonate”, “newborn” and “neonatal intensive care unit” (NICU). After screening, 223 articles of relevance were included. Results show incidences of S. capitis outbreaks have frequently been associated with the outbreak clone (NRCS-A) and environmental sources. The NRCS-A harbours a multidrug resistance profile that includes resistance to beta-lactam antibiotics and aminoglycosides, with several papers noting resistance or heteroresistance to vancomycin. The NRCS-A clone also harbours a novel SCCmec-SCCcad/ars/cop composite island and increased vancomycin resistance. The S. capitis NRCS-A clone has been detected for decades, but the reasons for the potentially increased frequency are unclear, as are the most effective interventions to manage outbreaks associated with this clone. This supports the need for improvements in environmental control and decontamination strategies to prevent transmission.
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spelling pubmed-101352222023-04-28 Staphylococcus capitis: Review of Its Role in Infections and Outbreaks Heath, Victoria Cloutman-Green, Elaine Watkin, Samuel Karlikowska, Magdalena Ready, Derren Hatcher, James Pearce-Smith, Nicola Brown, Colin Demirjian, Alicia Antibiotics (Basel) Review In June 2021, a national incident team was formed due to an increased detection of Staphylococcus capitis in samples from hospitalised infants. Staphylococcus capitis has been known to cause outbreaks in neonatal units across the globe, but the extent of the UK spread was unclear. A literature review was undertaken to support case identification, clinical management and environmental infection control. A literature search was undertaken on multiple databases from inception to 24 May 2021, using keywords such as “Staphylococcus capitis”, “NRCS-A”, “S. capitis”, “neonate”, “newborn” and “neonatal intensive care unit” (NICU). After screening, 223 articles of relevance were included. Results show incidences of S. capitis outbreaks have frequently been associated with the outbreak clone (NRCS-A) and environmental sources. The NRCS-A harbours a multidrug resistance profile that includes resistance to beta-lactam antibiotics and aminoglycosides, with several papers noting resistance or heteroresistance to vancomycin. The NRCS-A clone also harbours a novel SCCmec-SCCcad/ars/cop composite island and increased vancomycin resistance. The S. capitis NRCS-A clone has been detected for decades, but the reasons for the potentially increased frequency are unclear, as are the most effective interventions to manage outbreaks associated with this clone. This supports the need for improvements in environmental control and decontamination strategies to prevent transmission. MDPI 2023-03-29 /pmc/articles/PMC10135222/ /pubmed/37107031 http://dx.doi.org/10.3390/antibiotics12040669 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Heath, Victoria
Cloutman-Green, Elaine
Watkin, Samuel
Karlikowska, Magdalena
Ready, Derren
Hatcher, James
Pearce-Smith, Nicola
Brown, Colin
Demirjian, Alicia
Staphylococcus capitis: Review of Its Role in Infections and Outbreaks
title Staphylococcus capitis: Review of Its Role in Infections and Outbreaks
title_full Staphylococcus capitis: Review of Its Role in Infections and Outbreaks
title_fullStr Staphylococcus capitis: Review of Its Role in Infections and Outbreaks
title_full_unstemmed Staphylococcus capitis: Review of Its Role in Infections and Outbreaks
title_short Staphylococcus capitis: Review of Its Role in Infections and Outbreaks
title_sort staphylococcus capitis: review of its role in infections and outbreaks
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135222/
https://www.ncbi.nlm.nih.gov/pubmed/37107031
http://dx.doi.org/10.3390/antibiotics12040669
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