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SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver

Transition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunct...

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Detalles Bibliográficos
Autores principales: Vatamaniuk, Marko Z., Huang, Rong, Zhao, Zeping, Lei, Xin Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135242/
https://www.ncbi.nlm.nih.gov/pubmed/37107221
http://dx.doi.org/10.3390/antiox12040846
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author Vatamaniuk, Marko Z.
Huang, Rong
Zhao, Zeping
Lei, Xin Gen
author_facet Vatamaniuk, Marko Z.
Huang, Rong
Zhao, Zeping
Lei, Xin Gen
author_sort Vatamaniuk, Marko Z.
collection PubMed
description Transition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunction and/or diseases. Here, we used synchrotron X-ray fluorescence, SXRF, microscopy and mice with altered functions of major antioxidant enzymes to show that SXRF may become a powerful tool to study biologically relevant metal balance in the pancreas and liver of mice models with disturbed glucose homeostasis.
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spelling pubmed-101352422023-04-28 SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver Vatamaniuk, Marko Z. Huang, Rong Zhao, Zeping Lei, Xin Gen Antioxidants (Basel) Communication Transition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunction and/or diseases. Here, we used synchrotron X-ray fluorescence, SXRF, microscopy and mice with altered functions of major antioxidant enzymes to show that SXRF may become a powerful tool to study biologically relevant metal balance in the pancreas and liver of mice models with disturbed glucose homeostasis. MDPI 2023-04-01 /pmc/articles/PMC10135242/ /pubmed/37107221 http://dx.doi.org/10.3390/antiox12040846 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Vatamaniuk, Marko Z.
Huang, Rong
Zhao, Zeping
Lei, Xin Gen
SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver
title SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver
title_full SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver
title_fullStr SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver
title_full_unstemmed SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver
title_short SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver
title_sort sxrf for studying the distribution of trace metals in the pancreas and liver
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135242/
https://www.ncbi.nlm.nih.gov/pubmed/37107221
http://dx.doi.org/10.3390/antiox12040846
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