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SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver
Transition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunct...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135242/ https://www.ncbi.nlm.nih.gov/pubmed/37107221 http://dx.doi.org/10.3390/antiox12040846 |
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author | Vatamaniuk, Marko Z. Huang, Rong Zhao, Zeping Lei, Xin Gen |
author_facet | Vatamaniuk, Marko Z. Huang, Rong Zhao, Zeping Lei, Xin Gen |
author_sort | Vatamaniuk, Marko Z. |
collection | PubMed |
description | Transition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunction and/or diseases. Here, we used synchrotron X-ray fluorescence, SXRF, microscopy and mice with altered functions of major antioxidant enzymes to show that SXRF may become a powerful tool to study biologically relevant metal balance in the pancreas and liver of mice models with disturbed glucose homeostasis. |
format | Online Article Text |
id | pubmed-10135242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101352422023-04-28 SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver Vatamaniuk, Marko Z. Huang, Rong Zhao, Zeping Lei, Xin Gen Antioxidants (Basel) Communication Transition metals such as iron, copper and zinc are required for the normal functioning of biological tissues, whereas others, such as cadmium, are potentially highly toxic. Any disturbances in homeostasis caused by lack of micronutrients in the diet, pollution or genetic heredity result in malfunction and/or diseases. Here, we used synchrotron X-ray fluorescence, SXRF, microscopy and mice with altered functions of major antioxidant enzymes to show that SXRF may become a powerful tool to study biologically relevant metal balance in the pancreas and liver of mice models with disturbed glucose homeostasis. MDPI 2023-04-01 /pmc/articles/PMC10135242/ /pubmed/37107221 http://dx.doi.org/10.3390/antiox12040846 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Vatamaniuk, Marko Z. Huang, Rong Zhao, Zeping Lei, Xin Gen SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
title | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
title_full | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
title_fullStr | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
title_full_unstemmed | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
title_short | SXRF for Studying the Distribution of Trace Metals in the Pancreas and Liver |
title_sort | sxrf for studying the distribution of trace metals in the pancreas and liver |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135242/ https://www.ncbi.nlm.nih.gov/pubmed/37107221 http://dx.doi.org/10.3390/antiox12040846 |
work_keys_str_mv | AT vatamaniukmarkoz sxrfforstudyingthedistributionoftracemetalsinthepancreasandliver AT huangrong sxrfforstudyingthedistributionoftracemetalsinthepancreasandliver AT zhaozeping sxrfforstudyingthedistributionoftracemetalsinthepancreasandliver AT leixingen sxrfforstudyingthedistributionoftracemetalsinthepancreasandliver |