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NAD+ Biosynthesis Impairment and Acute Kidney Injury after Major Vascular Surgery

Acute kidney injury (AKI) is a serious complication after vascular surgery. Reduced synthesis of nicotinamide adenine dinucleotide (NAD+) from tryptophan is associated with an increased risk of AKI in critically ill patients, patients hospitalized with COVID-19, and cardiac surgery patients, and is...

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Autores principales: Mede, Annmarie I., Milne, Ginger L., Wei, Dawei, Smith, Derek K., Smith, Loren E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135380/
https://www.ncbi.nlm.nih.gov/pubmed/37107195
http://dx.doi.org/10.3390/antiox12040821
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author Mede, Annmarie I.
Milne, Ginger L.
Wei, Dawei
Smith, Derek K.
Smith, Loren E.
author_facet Mede, Annmarie I.
Milne, Ginger L.
Wei, Dawei
Smith, Derek K.
Smith, Loren E.
author_sort Mede, Annmarie I.
collection PubMed
description Acute kidney injury (AKI) is a serious complication after vascular surgery. Reduced synthesis of nicotinamide adenine dinucleotide (NAD+) from tryptophan is associated with an increased risk of AKI in critically ill patients, patients hospitalized with COVID-19, and cardiac surgery patients, and is marked by elevated urinary quinolinate and quinolinate to tryptophan ratios. We measured quinolinate concentrations in vascular surgery patients to determine if impaired NAD+ synthesis was associated with AKI in this patient population. Eight preoperative and eight postoperative vascular surgery patients who developed AKI were selected from a parent study to participate in this single-center case-control study. They were matched with controls who did not develop AKI based on age, sex, BMI, eGFR, hypertension, and diabetes. Urinary quinolinate and tryptophan concentrations were measured at anesthetic induction and on postoperative day one. Two-sided Mann–Whitney U tests were used to compare quinolinate and quinolinate to tryptophan ratios. Multivariate linear regression modeling was used to estimate the relationship between quinolinate and serum creatinine. There was no difference in preoperative or postoperative urine quinolinate concentrations or the preoperative quinolinate to tryptophan ratio between patients that did and did not develop AKI (p = 0.07, 0.50, and 0.32, respectively). However, postoperative quinolinate to tryptophan ratios were higher in AKI patients (p = 0.04). Further, after adjustment for AKI risk factors, higher preoperative quinolinate concentrations and higher postoperative quinolinate to tryptophan ratios were associated with greater postoperative creatinine increases (p = 0.04 and 0.04, respectively). These data suggest that impaired NAD+ synthesis may contribute to AKI development in vascular surgery patients.
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spelling pubmed-101353802023-04-28 NAD+ Biosynthesis Impairment and Acute Kidney Injury after Major Vascular Surgery Mede, Annmarie I. Milne, Ginger L. Wei, Dawei Smith, Derek K. Smith, Loren E. Antioxidants (Basel) Article Acute kidney injury (AKI) is a serious complication after vascular surgery. Reduced synthesis of nicotinamide adenine dinucleotide (NAD+) from tryptophan is associated with an increased risk of AKI in critically ill patients, patients hospitalized with COVID-19, and cardiac surgery patients, and is marked by elevated urinary quinolinate and quinolinate to tryptophan ratios. We measured quinolinate concentrations in vascular surgery patients to determine if impaired NAD+ synthesis was associated with AKI in this patient population. Eight preoperative and eight postoperative vascular surgery patients who developed AKI were selected from a parent study to participate in this single-center case-control study. They were matched with controls who did not develop AKI based on age, sex, BMI, eGFR, hypertension, and diabetes. Urinary quinolinate and tryptophan concentrations were measured at anesthetic induction and on postoperative day one. Two-sided Mann–Whitney U tests were used to compare quinolinate and quinolinate to tryptophan ratios. Multivariate linear regression modeling was used to estimate the relationship between quinolinate and serum creatinine. There was no difference in preoperative or postoperative urine quinolinate concentrations or the preoperative quinolinate to tryptophan ratio between patients that did and did not develop AKI (p = 0.07, 0.50, and 0.32, respectively). However, postoperative quinolinate to tryptophan ratios were higher in AKI patients (p = 0.04). Further, after adjustment for AKI risk factors, higher preoperative quinolinate concentrations and higher postoperative quinolinate to tryptophan ratios were associated with greater postoperative creatinine increases (p = 0.04 and 0.04, respectively). These data suggest that impaired NAD+ synthesis may contribute to AKI development in vascular surgery patients. MDPI 2023-03-28 /pmc/articles/PMC10135380/ /pubmed/37107195 http://dx.doi.org/10.3390/antiox12040821 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mede, Annmarie I.
Milne, Ginger L.
Wei, Dawei
Smith, Derek K.
Smith, Loren E.
NAD+ Biosynthesis Impairment and Acute Kidney Injury after Major Vascular Surgery
title NAD+ Biosynthesis Impairment and Acute Kidney Injury after Major Vascular Surgery
title_full NAD+ Biosynthesis Impairment and Acute Kidney Injury after Major Vascular Surgery
title_fullStr NAD+ Biosynthesis Impairment and Acute Kidney Injury after Major Vascular Surgery
title_full_unstemmed NAD+ Biosynthesis Impairment and Acute Kidney Injury after Major Vascular Surgery
title_short NAD+ Biosynthesis Impairment and Acute Kidney Injury after Major Vascular Surgery
title_sort nad+ biosynthesis impairment and acute kidney injury after major vascular surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135380/
https://www.ncbi.nlm.nih.gov/pubmed/37107195
http://dx.doi.org/10.3390/antiox12040821
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