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Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies

The survival rate of patients with osteosarcoma (OS) has not improved over the last 30 years. Mutations in the genes TP53, RB1 and c-Myc frequently occur in OS and enhance RNA Polymerase I (Pol I) activity, thus supporting uncontrolled cancer cell proliferation. We therefore hypothesised that Pol I...

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Detalles Bibliográficos
Autores principales:	Kang, Chang-Won, Blackburn, Anneke C., Loh, Amos Hong Pheng, Hong, Kuick Chick, Goh, Jian Yuan, Hein, Nadine, Drygin, Denis, Parish, Chris R., Hannan, Ross D., Hannan, Katherine M., Coupland, Lucy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135452/ https://www.ncbi.nlm.nih.gov/pubmed/37189750 http://dx.doi.org/10.3390/biomedicines11041133

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