Cargando…

Enhancing the Conformational Stability of the cl-Par-4 Tumor Suppressor via Site-Directed Mutagenesis

Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4), an approximately 40 kilodalton proapoptotic tumor suppressor, is a predominantly intrinsically disordered protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pandey, Samjhana, Raut, Krishna K., Clark, Andrea M., Baudin, Antoine, Djemri, Lamya, Libich, David S., Ponniah, Komala, Pascal, Steven M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135485/ https://www.ncbi.nlm.nih.gov/pubmed/37189414 http://dx.doi.org/10.3390/biom13040667

Ejemplares similares

Structural Analysis of the cl-Par-4 Tumor Suppressor as a Function of Ionic Environment
por: Raut, Krishna K., et al.
Publicado: (2021)

pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain
por: Clark, Andrea M., et al.
Publicado: (2018)

Order and disorder bound together in SARS-CoV-2 Nsp1 suppress host translation
por: Libich, David S., et al.
Publicado: (2023)

Conformational flexibility in the enterovirus RNA replication platform
por: Warden, Meghan S., et al.
Publicado: (2019)

514 Understanding Structural and Dynamic Effects of the EWS-FLI1 interactome on the EWS Low Complexity Domain Function
por: Parra, George Louis, et al.
Publicado: (2023)

Structural Characterization of the RNA-Binding Protein SERBP1 Reveals Intrinsic Disorder and Atypical RNA Binding Modes
por: Baudin, Antoine, et al.
Publicado: (2021)

Methylation of the D2 dopamine receptor affects binding with the human regulatory proteins Par-4 and Calmodulin
por: Bowitch, Alexander, et al.
Publicado: (2021)

Insights into Molecular Diversity within the FET Family: Unraveling Phase Separation of the N-Terminal Low Complexity Domain from RNA-Binding Protein EWS
por: Johnson, Courtney N., et al.
Publicado: (2023)

Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis
por: Sahoo, Anusmita, et al.
Publicado: (2015)

Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation
por: Aiderus, Aziz, et al.
Publicado: (2021)

Evolutionary Divergent Suppressor Mutations in Conformational Diseases
por: Mesa-Torres, Noel, et al.
Publicado: (2018)

Impact of Ethyl Methane Sulphonate Mutagenesis in Artemisia vulgaris L. under NaCl Stress
por: Kumar, Sudheeran Pradeep, et al.
Publicado: (2021)

Genomic-Destabilization-Associated Mutagenesis and Clonal Evolution of Cells with Mutations in Tumor-Suppressor Genes
por: Yoshioka, Ken-ichi, et al.
Publicado: (2019)

Stabilization of a prokaryotic LAT transporter by random mutagenesis
por: Rodríguez-Banqueri, Arturo, et al.
Publicado: (2016)

Probing the conformation of a conserved glutamic acid within the Cl(−) pathway of a CLC H(+)/Cl(−) exchanger
por: Vien, Malvin, et al.
Publicado: (2017)

Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points
por: Norris, Anne, et al.
Publicado: (2022)

O(6)-methylguanine–induced transcriptional mutagenesis reduces p53 tumor-suppressor function
por: Ezerskyte, Monika, et al.
Publicado: (2018)

Targeted Mutagenesis of the Female-Suppressor SyGI Gene in Tetraploid Kiwifruit by CRISPR/CAS9
por: De Mori, Gloria, et al.
Publicado: (2020)

Tumor Suppressor Par-4 Regulates Complement Factor C3 and Obesity
por: Araujo, Nathalia, et al.
Publicado: (2022)

Mutagenesis of Trichoderma reesei endoglucanase I: impact of expression host on activity and stability at elevated temperatures
por: Chokhawala, Harshal A, et al.
Publicado: (2015)

Conformational changes required for H(+)/Cl– exchange mediated by a CLC transporter
por: Basilio, Daniel, et al.
Publicado: (2014)

CRISPR/Cas9-mediated mutagenesis of ClBG1 decreased seed size and promoted seed germination in watermelon
por: Wang, Yanping, et al.
Publicado: (2021)

Mutagenesis after cancer therapy.
por: Kelsey, K T, et al.
Publicado: (1993)

A saturation-mutagenesis analysis of the interplay between stability and activation in Ras
por: Hidalgo, Frank, et al.
Publicado: (2022)

Identification of stabilizing point mutations through mutagenesis of destabilized protein libraries
por: Ahmed, Shahbaz, et al.
Publicado: (2022)

Islands of Conformational Stability for Filopodia
por: Daniels, D. Robert, et al.
Publicado: (2013)

Oligoarray Comparative Genomic Hybridization-Mediated Mapping of Suppressor Mutations Generated in a Deletion-Biased Mutagenesis Screen
por: Jones, Martin R., et al.
Publicado: (2012)

Conformational flexibility determines the Nf2/merlin tumor suppressor functions
por: Primi, Marina C., et al.
Publicado: (2021)

Sur les théories des champs invariantes par rapport au groupe conforme
por: Omnès, Roland
Publicado: (1957)

ATP-regulated interactions between P1 ParA, ParB and non-specific DNA that are stabilized by the plasmid partition site, parS
por: Havey, James C., et al.
Publicado: (2012)

The epidermal polarity protein Par3 is a non–cell autonomous suppressor of malignant melanoma
por: Mescher, Melina, et al.
Publicado: (2017)

Golden Mutagenesis: An efficient multi-site-saturation mutagenesis approach by Golden Gate cloning with automated primer design
por: Püllmann, Pascal, et al.
Publicado: (2019)

A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes
por: de la Rosa, Jorge, et al.
Publicado: (2017)

L-Alanine Prototrophic Suppressors Emerge from L-Alanine Auxotroph through Stress-Induced Mutagenesis in Escherichia coli
por: Mishima, Harutaka, et al.
Publicado: (2021)

AcrB Trimer Stability and Efflux Activity, Insight from Mutagenesis Studies
por: Yu, Linliang, et al.
Publicado: (2011)

Global computational mutagenesis provides a critical stability framework in protein structures
por: McCafferty, Caitlyn L., et al.
Publicado: (2017)

Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin()
por: Kettisen, Karin, et al.
Publicado: (2018)

Role of site-directed mutagenesis and adjuvants in the stability and potency of anthrax protective antigen
por: Dahhas, Mohammed Ali, et al.
Publicado: (2022)

Targeted mutagenesis of StISAC stabilizes the production of anthocyanins in potato cell culture
por: D'Amelia, Vincenzo, et al.
Publicado: (2022)

Conformational Heterogeneity and Frustration of the Tumor Suppressor p53 as Tuned by Punctual Mutations
por: Bizzarri, Anna Rita
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jdsmu2v24lk3h7rdr4r5nao9je