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Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters
The gene encoding brain-derived neurotrophic factor (Bdnf) consists of nine non-coding exons driven by unique promoters, leading to the expression of nine Bdnf transcripts that play different roles in various brain regions and physiological stages. In this manuscript, we present a comprehensive over...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135494/ https://www.ncbi.nlm.nih.gov/pubmed/37189402 http://dx.doi.org/10.3390/biom13040655 |
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author | You, He Lu, Bai |
author_facet | You, He Lu, Bai |
author_sort | You, He |
collection | PubMed |
description | The gene encoding brain-derived neurotrophic factor (Bdnf) consists of nine non-coding exons driven by unique promoters, leading to the expression of nine Bdnf transcripts that play different roles in various brain regions and physiological stages. In this manuscript, we present a comprehensive overview of the molecular regulation and structural characteristics of the multiple Bdnf promoters, along with a summary of the current knowledge on the cellular and physiological functions of the distinct Bdnf transcripts produced by these promoters. Specifically, we summarized the role of Bdnf transcripts in psychiatric disorders, including schizophrenia and anxiety, as well as the cognitive functions associated with specific Bdnf promoters. Moreover, we examine the involvement of different Bdnf promoters in various aspects of metabolism. Finally, we propose future research directions that will enhance our understanding of the complex functions of Bdnf and its diverse promoters. |
format | Online Article Text |
id | pubmed-10135494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101354942023-04-28 Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters You, He Lu, Bai Biomolecules Review The gene encoding brain-derived neurotrophic factor (Bdnf) consists of nine non-coding exons driven by unique promoters, leading to the expression of nine Bdnf transcripts that play different roles in various brain regions and physiological stages. In this manuscript, we present a comprehensive overview of the molecular regulation and structural characteristics of the multiple Bdnf promoters, along with a summary of the current knowledge on the cellular and physiological functions of the distinct Bdnf transcripts produced by these promoters. Specifically, we summarized the role of Bdnf transcripts in psychiatric disorders, including schizophrenia and anxiety, as well as the cognitive functions associated with specific Bdnf promoters. Moreover, we examine the involvement of different Bdnf promoters in various aspects of metabolism. Finally, we propose future research directions that will enhance our understanding of the complex functions of Bdnf and its diverse promoters. MDPI 2023-04-06 /pmc/articles/PMC10135494/ /pubmed/37189402 http://dx.doi.org/10.3390/biom13040655 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review You, He Lu, Bai Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters |
title | Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters |
title_full | Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters |
title_fullStr | Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters |
title_full_unstemmed | Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters |
title_short | Diverse Functions of Multiple Bdnf Transcripts Driven by Distinct Bdnf Promoters |
title_sort | diverse functions of multiple bdnf transcripts driven by distinct bdnf promoters |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135494/ https://www.ncbi.nlm.nih.gov/pubmed/37189402 http://dx.doi.org/10.3390/biom13040655 |
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