Cargando…
Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes
Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces for augmented cytosolic and mitochondrial reactive oxygen species (ROS) in diabetes mellitus (DM), fostering the development of vascular complications such as diabetic nephropathy, diabetic cardiomyopathy, diab...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135521/ https://www.ncbi.nlm.nih.gov/pubmed/37107272 http://dx.doi.org/10.3390/antiox12040898 |
_version_ | 1785031998737219584 |
---|---|
author | Pant, Tarun Uche, Nnamdi Juric, Matea Bosnjak, Zeljko J. |
author_facet | Pant, Tarun Uche, Nnamdi Juric, Matea Bosnjak, Zeljko J. |
author_sort | Pant, Tarun |
collection | PubMed |
description | Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces for augmented cytosolic and mitochondrial reactive oxygen species (ROS) in diabetes mellitus (DM), fostering the development of vascular complications such as diabetic nephropathy, diabetic cardiomyopathy, diabetic neuropathy, and diabetic retinopathy. Therefore, specific therapeutic approaches capable of modulating oxidative milieu may provide a preventative and/or therapeutic benefit against the development of cardiovascular complications in diabetes patients. Recent studies have demonstrated epigenetic alterations in circulating and tissue-specific long non-coding RNA (lncRNA) signatures in vascular complications of DM regulating mitochondrial function under oxidative stress. Intriguingly, over the past decade mitochondria-targeted antioxidants (MTAs) have emerged as a promising therapeutic option for managing oxidative stress-induced diseases. Here, we review the present status of lncRNA as a diagnostic biomarker and potential regulator of oxidative stress in vascular complications of DM. We also discuss the recent advances in using MTAs in different animal models and clinical trials. We summarize the prospects and challenges for the use of MTAs in treating vascular diseases and their application in translation medicine, which may be beneficial in MTA drug design development, and their application in translational medicine. |
format | Online Article Text |
id | pubmed-10135521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101355212023-04-28 Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes Pant, Tarun Uche, Nnamdi Juric, Matea Bosnjak, Zeljko J. Antioxidants (Basel) Review Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces for augmented cytosolic and mitochondrial reactive oxygen species (ROS) in diabetes mellitus (DM), fostering the development of vascular complications such as diabetic nephropathy, diabetic cardiomyopathy, diabetic neuropathy, and diabetic retinopathy. Therefore, specific therapeutic approaches capable of modulating oxidative milieu may provide a preventative and/or therapeutic benefit against the development of cardiovascular complications in diabetes patients. Recent studies have demonstrated epigenetic alterations in circulating and tissue-specific long non-coding RNA (lncRNA) signatures in vascular complications of DM regulating mitochondrial function under oxidative stress. Intriguingly, over the past decade mitochondria-targeted antioxidants (MTAs) have emerged as a promising therapeutic option for managing oxidative stress-induced diseases. Here, we review the present status of lncRNA as a diagnostic biomarker and potential regulator of oxidative stress in vascular complications of DM. We also discuss the recent advances in using MTAs in different animal models and clinical trials. We summarize the prospects and challenges for the use of MTAs in treating vascular diseases and their application in translation medicine, which may be beneficial in MTA drug design development, and their application in translational medicine. MDPI 2023-04-07 /pmc/articles/PMC10135521/ /pubmed/37107272 http://dx.doi.org/10.3390/antiox12040898 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pant, Tarun Uche, Nnamdi Juric, Matea Bosnjak, Zeljko J. Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes |
title | Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes |
title_full | Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes |
title_fullStr | Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes |
title_full_unstemmed | Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes |
title_short | Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes |
title_sort | clinical relevance of lncrna and mitochondrial targeted antioxidants as therapeutic options in regulating oxidative stress and mitochondrial function in vascular complications of diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135521/ https://www.ncbi.nlm.nih.gov/pubmed/37107272 http://dx.doi.org/10.3390/antiox12040898 |
work_keys_str_mv | AT panttarun clinicalrelevanceoflncrnaandmitochondrialtargetedantioxidantsastherapeuticoptionsinregulatingoxidativestressandmitochondrialfunctioninvascularcomplicationsofdiabetes AT uchennamdi clinicalrelevanceoflncrnaandmitochondrialtargetedantioxidantsastherapeuticoptionsinregulatingoxidativestressandmitochondrialfunctioninvascularcomplicationsofdiabetes AT juricmatea clinicalrelevanceoflncrnaandmitochondrialtargetedantioxidantsastherapeuticoptionsinregulatingoxidativestressandmitochondrialfunctioninvascularcomplicationsofdiabetes AT bosnjakzeljkoj clinicalrelevanceoflncrnaandmitochondrialtargetedantioxidantsastherapeuticoptionsinregulatingoxidativestressandmitochondrialfunctioninvascularcomplicationsofdiabetes |