Cargando…

Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes

Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces for augmented cytosolic and mitochondrial reactive oxygen species (ROS) in diabetes mellitus (DM), fostering the development of vascular complications such as diabetic nephropathy, diabetic cardiomyopathy, diab...

Descripción completa

Detalles Bibliográficos
Autores principales: Pant, Tarun, Uche, Nnamdi, Juric, Matea, Bosnjak, Zeljko J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135521/
https://www.ncbi.nlm.nih.gov/pubmed/37107272
http://dx.doi.org/10.3390/antiox12040898
_version_ 1785031998737219584
author Pant, Tarun
Uche, Nnamdi
Juric, Matea
Bosnjak, Zeljko J.
author_facet Pant, Tarun
Uche, Nnamdi
Juric, Matea
Bosnjak, Zeljko J.
author_sort Pant, Tarun
collection PubMed
description Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces for augmented cytosolic and mitochondrial reactive oxygen species (ROS) in diabetes mellitus (DM), fostering the development of vascular complications such as diabetic nephropathy, diabetic cardiomyopathy, diabetic neuropathy, and diabetic retinopathy. Therefore, specific therapeutic approaches capable of modulating oxidative milieu may provide a preventative and/or therapeutic benefit against the development of cardiovascular complications in diabetes patients. Recent studies have demonstrated epigenetic alterations in circulating and tissue-specific long non-coding RNA (lncRNA) signatures in vascular complications of DM regulating mitochondrial function under oxidative stress. Intriguingly, over the past decade mitochondria-targeted antioxidants (MTAs) have emerged as a promising therapeutic option for managing oxidative stress-induced diseases. Here, we review the present status of lncRNA as a diagnostic biomarker and potential regulator of oxidative stress in vascular complications of DM. We also discuss the recent advances in using MTAs in different animal models and clinical trials. We summarize the prospects and challenges for the use of MTAs in treating vascular diseases and their application in translation medicine, which may be beneficial in MTA drug design development, and their application in translational medicine.
format Online
Article
Text
id pubmed-10135521
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101355212023-04-28 Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes Pant, Tarun Uche, Nnamdi Juric, Matea Bosnjak, Zeljko J. Antioxidants (Basel) Review Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces for augmented cytosolic and mitochondrial reactive oxygen species (ROS) in diabetes mellitus (DM), fostering the development of vascular complications such as diabetic nephropathy, diabetic cardiomyopathy, diabetic neuropathy, and diabetic retinopathy. Therefore, specific therapeutic approaches capable of modulating oxidative milieu may provide a preventative and/or therapeutic benefit against the development of cardiovascular complications in diabetes patients. Recent studies have demonstrated epigenetic alterations in circulating and tissue-specific long non-coding RNA (lncRNA) signatures in vascular complications of DM regulating mitochondrial function under oxidative stress. Intriguingly, over the past decade mitochondria-targeted antioxidants (MTAs) have emerged as a promising therapeutic option for managing oxidative stress-induced diseases. Here, we review the present status of lncRNA as a diagnostic biomarker and potential regulator of oxidative stress in vascular complications of DM. We also discuss the recent advances in using MTAs in different animal models and clinical trials. We summarize the prospects and challenges for the use of MTAs in treating vascular diseases and their application in translation medicine, which may be beneficial in MTA drug design development, and their application in translational medicine. MDPI 2023-04-07 /pmc/articles/PMC10135521/ /pubmed/37107272 http://dx.doi.org/10.3390/antiox12040898 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pant, Tarun
Uche, Nnamdi
Juric, Matea
Bosnjak, Zeljko J.
Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes
title Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes
title_full Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes
title_fullStr Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes
title_full_unstemmed Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes
title_short Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes
title_sort clinical relevance of lncrna and mitochondrial targeted antioxidants as therapeutic options in regulating oxidative stress and mitochondrial function in vascular complications of diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135521/
https://www.ncbi.nlm.nih.gov/pubmed/37107272
http://dx.doi.org/10.3390/antiox12040898
work_keys_str_mv AT panttarun clinicalrelevanceoflncrnaandmitochondrialtargetedantioxidantsastherapeuticoptionsinregulatingoxidativestressandmitochondrialfunctioninvascularcomplicationsofdiabetes
AT uchennamdi clinicalrelevanceoflncrnaandmitochondrialtargetedantioxidantsastherapeuticoptionsinregulatingoxidativestressandmitochondrialfunctioninvascularcomplicationsofdiabetes
AT juricmatea clinicalrelevanceoflncrnaandmitochondrialtargetedantioxidantsastherapeuticoptionsinregulatingoxidativestressandmitochondrialfunctioninvascularcomplicationsofdiabetes
AT bosnjakzeljkoj clinicalrelevanceoflncrnaandmitochondrialtargetedantioxidantsastherapeuticoptionsinregulatingoxidativestressandmitochondrialfunctioninvascularcomplicationsofdiabetes