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Angiopoietin-like 2 Protein and Hidradenitis Suppurativa: A New Biomarker for Disease Severity
Hidradenitis suppurativa (HS) is a chronic inflammatory disease whose pathogenesis is not fully understood at present. The role of proinflammatory cytokines, several adipokines, retinol-binding protein 4, angiopoietin-2 and other molecules has been previously reported. Angiopoietin-like 2 protein (A...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135524/ https://www.ncbi.nlm.nih.gov/pubmed/37189824 http://dx.doi.org/10.3390/biomedicines11041204 |
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author | Hernández, José L. Ocejo-Vinyals, J. Gonzalo Renuncio-García, Mónica González-López, Elena Blanco, Ricardo González-López, Marcos A. |
author_facet | Hernández, José L. Ocejo-Vinyals, J. Gonzalo Renuncio-García, Mónica González-López, Elena Blanco, Ricardo González-López, Marcos A. |
author_sort | Hernández, José L. |
collection | PubMed |
description | Hidradenitis suppurativa (HS) is a chronic inflammatory disease whose pathogenesis is not fully understood at present. The role of proinflammatory cytokines, several adipokines, retinol-binding protein 4, angiopoietin-2 and other molecules has been previously reported. Angiopoietin-like 2 protein (ANGPTL2) is a glycoprotein belonging to the angiopoietin-like family that may play a pivotal role in the pathogenesis of several chronic inflammatory diseases. To our knowledge, the role of serum ANGPTL2 levels in HS has not been assessed to date. In the current case–control study, we aimed to investigate serum ANGPTL2 levels in HS patients and controls and to assess whether ANGPTL2 levels could be associated with the severity of HS. Ninety-four patients with HS and sixty controls of similar age and sex were included in the study. Demographic, anthropometric, and clinical data, as well as routine laboratory parameters and serum concentrations of ANGPTL2, were assessed in all participants. HS patients had significantly higher serum ANGPTL2 levels than controls after adjusting for confounders. Moreover, ANGPTL2 concentrations positively correlated with disease duration and severity. Our results indicate for the first time that serum ANGPTL2 concentrations are elevated in HS patients compared to controls and correlate with the duration of the disease. Besides, ANGPTL2 might serve as a biomarker of HS severity. |
format | Online Article Text |
id | pubmed-10135524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101355242023-04-28 Angiopoietin-like 2 Protein and Hidradenitis Suppurativa: A New Biomarker for Disease Severity Hernández, José L. Ocejo-Vinyals, J. Gonzalo Renuncio-García, Mónica González-López, Elena Blanco, Ricardo González-López, Marcos A. Biomedicines Article Hidradenitis suppurativa (HS) is a chronic inflammatory disease whose pathogenesis is not fully understood at present. The role of proinflammatory cytokines, several adipokines, retinol-binding protein 4, angiopoietin-2 and other molecules has been previously reported. Angiopoietin-like 2 protein (ANGPTL2) is a glycoprotein belonging to the angiopoietin-like family that may play a pivotal role in the pathogenesis of several chronic inflammatory diseases. To our knowledge, the role of serum ANGPTL2 levels in HS has not been assessed to date. In the current case–control study, we aimed to investigate serum ANGPTL2 levels in HS patients and controls and to assess whether ANGPTL2 levels could be associated with the severity of HS. Ninety-four patients with HS and sixty controls of similar age and sex were included in the study. Demographic, anthropometric, and clinical data, as well as routine laboratory parameters and serum concentrations of ANGPTL2, were assessed in all participants. HS patients had significantly higher serum ANGPTL2 levels than controls after adjusting for confounders. Moreover, ANGPTL2 concentrations positively correlated with disease duration and severity. Our results indicate for the first time that serum ANGPTL2 concentrations are elevated in HS patients compared to controls and correlate with the duration of the disease. Besides, ANGPTL2 might serve as a biomarker of HS severity. MDPI 2023-04-18 /pmc/articles/PMC10135524/ /pubmed/37189824 http://dx.doi.org/10.3390/biomedicines11041204 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hernández, José L. Ocejo-Vinyals, J. Gonzalo Renuncio-García, Mónica González-López, Elena Blanco, Ricardo González-López, Marcos A. Angiopoietin-like 2 Protein and Hidradenitis Suppurativa: A New Biomarker for Disease Severity |
title | Angiopoietin-like 2 Protein and Hidradenitis Suppurativa: A New Biomarker for Disease Severity |
title_full | Angiopoietin-like 2 Protein and Hidradenitis Suppurativa: A New Biomarker for Disease Severity |
title_fullStr | Angiopoietin-like 2 Protein and Hidradenitis Suppurativa: A New Biomarker for Disease Severity |
title_full_unstemmed | Angiopoietin-like 2 Protein and Hidradenitis Suppurativa: A New Biomarker for Disease Severity |
title_short | Angiopoietin-like 2 Protein and Hidradenitis Suppurativa: A New Biomarker for Disease Severity |
title_sort | angiopoietin-like 2 protein and hidradenitis suppurativa: a new biomarker for disease severity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135524/ https://www.ncbi.nlm.nih.gov/pubmed/37189824 http://dx.doi.org/10.3390/biomedicines11041204 |
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