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The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis
Left ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers and nutritional status in these patients. We evaluated the L...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135564/ https://www.ncbi.nlm.nih.gov/pubmed/37189644 http://dx.doi.org/10.3390/biomedicines11041026 |
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author | Coimbra, Susana Catarino, Cristina Sameiro Faria, Maria Nunes, José Pedro L. Rocha, Susana Valente, Maria João Rocha-Pereira, Petronila Bronze-da-Rocha, Elsa Bettencourt, Nuno Beco, Ana Marques, Sofia Homem de Melo Oliveira, José Gerardo Madureira, José Fernandes, João Carlos Miranda, Vasco Belo, Luís Santos-Silva, Alice |
author_facet | Coimbra, Susana Catarino, Cristina Sameiro Faria, Maria Nunes, José Pedro L. Rocha, Susana Valente, Maria João Rocha-Pereira, Petronila Bronze-da-Rocha, Elsa Bettencourt, Nuno Beco, Ana Marques, Sofia Homem de Melo Oliveira, José Gerardo Madureira, José Fernandes, João Carlos Miranda, Vasco Belo, Luís Santos-Silva, Alice |
author_sort | Coimbra, Susana |
collection | PubMed |
description | Left ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers and nutritional status in these patients. We evaluated the LV mass (LVM) and calculated the LVM index (LVMI) in 196 ESKD patients on dialysis; the levels of hemoglobin, calcium, phosphorus, parathyroid hormone, albumin, adiponectin, leptin, N-terminal pro B-type natriuretic peptide (NT-proBNP) and growth differentiation factor (GDF)-15 were analyzed. ESKD patients with LVH (n = 131) presented higher NT-proBNP and GDF-15, lower hemoglobin and, after adjustment for gender, lower leptin levels compared with non-LVH patients. LVH females also showed lower leptin than the non-LVH female group. In the LVH group, LVMI presented a negative correlation with leptin and a positive correlation with NT-proBNP. Leptin emerged as an independent determinant of LVMI in both groups, and NT-proBNP in the LVH group. Low hemoglobin and leptin and increased calcium, NT-proBNP and dialysis vintage are associated with an increased risk of developing LVH. In ESKD patients on dialysis, LVH is associated with lower leptin values (especially in women), which are negatively correlated with LVMI, and with higher levels of biomarkers of myocardial stress/injury. Leptin and NT-proBNP appear as independent determinants of LVMI; dialysis vintage, hemoglobin, calcium, NT-proBNP and leptin emerged as predicting markers for LVH development. Further studies are needed to better understand the role of leptin in LVH in ESKD patients. |
format | Online Article Text |
id | pubmed-10135564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101355642023-04-28 The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis Coimbra, Susana Catarino, Cristina Sameiro Faria, Maria Nunes, José Pedro L. Rocha, Susana Valente, Maria João Rocha-Pereira, Petronila Bronze-da-Rocha, Elsa Bettencourt, Nuno Beco, Ana Marques, Sofia Homem de Melo Oliveira, José Gerardo Madureira, José Fernandes, João Carlos Miranda, Vasco Belo, Luís Santos-Silva, Alice Biomedicines Article Left ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers and nutritional status in these patients. We evaluated the LV mass (LVM) and calculated the LVM index (LVMI) in 196 ESKD patients on dialysis; the levels of hemoglobin, calcium, phosphorus, parathyroid hormone, albumin, adiponectin, leptin, N-terminal pro B-type natriuretic peptide (NT-proBNP) and growth differentiation factor (GDF)-15 were analyzed. ESKD patients with LVH (n = 131) presented higher NT-proBNP and GDF-15, lower hemoglobin and, after adjustment for gender, lower leptin levels compared with non-LVH patients. LVH females also showed lower leptin than the non-LVH female group. In the LVH group, LVMI presented a negative correlation with leptin and a positive correlation with NT-proBNP. Leptin emerged as an independent determinant of LVMI in both groups, and NT-proBNP in the LVH group. Low hemoglobin and leptin and increased calcium, NT-proBNP and dialysis vintage are associated with an increased risk of developing LVH. In ESKD patients on dialysis, LVH is associated with lower leptin values (especially in women), which are negatively correlated with LVMI, and with higher levels of biomarkers of myocardial stress/injury. Leptin and NT-proBNP appear as independent determinants of LVMI; dialysis vintage, hemoglobin, calcium, NT-proBNP and leptin emerged as predicting markers for LVH development. Further studies are needed to better understand the role of leptin in LVH in ESKD patients. MDPI 2023-03-27 /pmc/articles/PMC10135564/ /pubmed/37189644 http://dx.doi.org/10.3390/biomedicines11041026 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Coimbra, Susana Catarino, Cristina Sameiro Faria, Maria Nunes, José Pedro L. Rocha, Susana Valente, Maria João Rocha-Pereira, Petronila Bronze-da-Rocha, Elsa Bettencourt, Nuno Beco, Ana Marques, Sofia Homem de Melo Oliveira, José Gerardo Madureira, José Fernandes, João Carlos Miranda, Vasco Belo, Luís Santos-Silva, Alice The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
title | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
title_full | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
title_fullStr | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
title_full_unstemmed | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
title_short | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
title_sort | association of leptin with left ventricular hypertrophy in end-stage kidney disease patients on dialysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135564/ https://www.ncbi.nlm.nih.gov/pubmed/37189644 http://dx.doi.org/10.3390/biomedicines11041026 |
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