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Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro
A novel accessory directing the blood from the outflow of a left ventricular assist device (LVAD) back through the left ventricular apex and across the aortic valve allows LVAD implantation via the left ventricular apex solely but may affect the LVAD performance. We quantified the effect of the acce...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135582/ https://www.ncbi.nlm.nih.gov/pubmed/37106673 http://dx.doi.org/10.3390/bioengineering10040486 |
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author | Meissner, Florian Eichelkraut, Derya Schimmel, Marius Maier, Sven Vestner, Heiko Schoen, Manuela Czerny, Martin Bothe, Wolfgang |
author_facet | Meissner, Florian Eichelkraut, Derya Schimmel, Marius Maier, Sven Vestner, Heiko Schoen, Manuela Czerny, Martin Bothe, Wolfgang |
author_sort | Meissner, Florian |
collection | PubMed |
description | A novel accessory directing the blood from the outflow of a left ventricular assist device (LVAD) back through the left ventricular apex and across the aortic valve allows LVAD implantation via the left ventricular apex solely but may affect the LVAD performance. We quantified the effect of the accessory on LVAD flow and pressure head in vitro. In a mock circulatory loop, a centrifugal-flow LVAD (HeartMate 3, Abbott, Abbott Park, IL, USA) with (Accessory) and without the accessory (Control) was compared under physiological conditions using a water/glycerol solution as a blood substitute. The pump was operated at 4000, 5200, and 6400 rpm and 5 different resistance levels. Flow, inlet, and outlet pressure were measured, and pressure head was calculated. Compared to the Control, flow and pressure head in the Accessory group were reduced by an overall average of 0.26 L/min and 9.9 mmHg (all speeds and resistance levels). The highest decline in flow and pressure head occurred at the lowest resistance levels. In conclusion, the accessory leads to a reduction of LVAD flow and pressure head that is enhanced by decreases in resistance. Future developments in the LVAD accessory’s design may reduce these effects and allow unimpaired LVAD performance and minimally invasive device implantation. |
format | Online Article Text |
id | pubmed-10135582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101355822023-04-28 Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro Meissner, Florian Eichelkraut, Derya Schimmel, Marius Maier, Sven Vestner, Heiko Schoen, Manuela Czerny, Martin Bothe, Wolfgang Bioengineering (Basel) Article A novel accessory directing the blood from the outflow of a left ventricular assist device (LVAD) back through the left ventricular apex and across the aortic valve allows LVAD implantation via the left ventricular apex solely but may affect the LVAD performance. We quantified the effect of the accessory on LVAD flow and pressure head in vitro. In a mock circulatory loop, a centrifugal-flow LVAD (HeartMate 3, Abbott, Abbott Park, IL, USA) with (Accessory) and without the accessory (Control) was compared under physiological conditions using a water/glycerol solution as a blood substitute. The pump was operated at 4000, 5200, and 6400 rpm and 5 different resistance levels. Flow, inlet, and outlet pressure were measured, and pressure head was calculated. Compared to the Control, flow and pressure head in the Accessory group were reduced by an overall average of 0.26 L/min and 9.9 mmHg (all speeds and resistance levels). The highest decline in flow and pressure head occurred at the lowest resistance levels. In conclusion, the accessory leads to a reduction of LVAD flow and pressure head that is enhanced by decreases in resistance. Future developments in the LVAD accessory’s design may reduce these effects and allow unimpaired LVAD performance and minimally invasive device implantation. MDPI 2023-04-19 /pmc/articles/PMC10135582/ /pubmed/37106673 http://dx.doi.org/10.3390/bioengineering10040486 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Meissner, Florian Eichelkraut, Derya Schimmel, Marius Maier, Sven Vestner, Heiko Schoen, Manuela Czerny, Martin Bothe, Wolfgang Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
title | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
title_full | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
title_fullStr | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
title_full_unstemmed | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
title_short | Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro |
title_sort | impact of an accessory for left ventricular assist devices on device flow and pressure head in vitro |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135582/ https://www.ncbi.nlm.nih.gov/pubmed/37106673 http://dx.doi.org/10.3390/bioengineering10040486 |
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