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Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro

A novel accessory directing the blood from the outflow of a left ventricular assist device (LVAD) back through the left ventricular apex and across the aortic valve allows LVAD implantation via the left ventricular apex solely but may affect the LVAD performance. We quantified the effect of the acce...

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Autores principales: Meissner, Florian, Eichelkraut, Derya, Schimmel, Marius, Maier, Sven, Vestner, Heiko, Schoen, Manuela, Czerny, Martin, Bothe, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135582/
https://www.ncbi.nlm.nih.gov/pubmed/37106673
http://dx.doi.org/10.3390/bioengineering10040486
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author Meissner, Florian
Eichelkraut, Derya
Schimmel, Marius
Maier, Sven
Vestner, Heiko
Schoen, Manuela
Czerny, Martin
Bothe, Wolfgang
author_facet Meissner, Florian
Eichelkraut, Derya
Schimmel, Marius
Maier, Sven
Vestner, Heiko
Schoen, Manuela
Czerny, Martin
Bothe, Wolfgang
author_sort Meissner, Florian
collection PubMed
description A novel accessory directing the blood from the outflow of a left ventricular assist device (LVAD) back through the left ventricular apex and across the aortic valve allows LVAD implantation via the left ventricular apex solely but may affect the LVAD performance. We quantified the effect of the accessory on LVAD flow and pressure head in vitro. In a mock circulatory loop, a centrifugal-flow LVAD (HeartMate 3, Abbott, Abbott Park, IL, USA) with (Accessory) and without the accessory (Control) was compared under physiological conditions using a water/glycerol solution as a blood substitute. The pump was operated at 4000, 5200, and 6400 rpm and 5 different resistance levels. Flow, inlet, and outlet pressure were measured, and pressure head was calculated. Compared to the Control, flow and pressure head in the Accessory group were reduced by an overall average of 0.26 L/min and 9.9 mmHg (all speeds and resistance levels). The highest decline in flow and pressure head occurred at the lowest resistance levels. In conclusion, the accessory leads to a reduction of LVAD flow and pressure head that is enhanced by decreases in resistance. Future developments in the LVAD accessory’s design may reduce these effects and allow unimpaired LVAD performance and minimally invasive device implantation.
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spelling pubmed-101355822023-04-28 Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro Meissner, Florian Eichelkraut, Derya Schimmel, Marius Maier, Sven Vestner, Heiko Schoen, Manuela Czerny, Martin Bothe, Wolfgang Bioengineering (Basel) Article A novel accessory directing the blood from the outflow of a left ventricular assist device (LVAD) back through the left ventricular apex and across the aortic valve allows LVAD implantation via the left ventricular apex solely but may affect the LVAD performance. We quantified the effect of the accessory on LVAD flow and pressure head in vitro. In a mock circulatory loop, a centrifugal-flow LVAD (HeartMate 3, Abbott, Abbott Park, IL, USA) with (Accessory) and without the accessory (Control) was compared under physiological conditions using a water/glycerol solution as a blood substitute. The pump was operated at 4000, 5200, and 6400 rpm and 5 different resistance levels. Flow, inlet, and outlet pressure were measured, and pressure head was calculated. Compared to the Control, flow and pressure head in the Accessory group were reduced by an overall average of 0.26 L/min and 9.9 mmHg (all speeds and resistance levels). The highest decline in flow and pressure head occurred at the lowest resistance levels. In conclusion, the accessory leads to a reduction of LVAD flow and pressure head that is enhanced by decreases in resistance. Future developments in the LVAD accessory’s design may reduce these effects and allow unimpaired LVAD performance and minimally invasive device implantation. MDPI 2023-04-19 /pmc/articles/PMC10135582/ /pubmed/37106673 http://dx.doi.org/10.3390/bioengineering10040486 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meissner, Florian
Eichelkraut, Derya
Schimmel, Marius
Maier, Sven
Vestner, Heiko
Schoen, Manuela
Czerny, Martin
Bothe, Wolfgang
Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro
title Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro
title_full Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro
title_fullStr Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro
title_full_unstemmed Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro
title_short Impact of an Accessory for Left Ventricular Assist Devices on Device Flow and Pressure Head In Vitro
title_sort impact of an accessory for left ventricular assist devices on device flow and pressure head in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135582/
https://www.ncbi.nlm.nih.gov/pubmed/37106673
http://dx.doi.org/10.3390/bioengineering10040486
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