Single-Particle Tracking of Thermomyces lanuginosus Lipase Reveals How Mutations in the Lid Region Remodel Its Diffusion

The function of most lipases is controlled by the lid, which undergoes conformational changes at a water–lipid interface to expose the active site, thus activating catalysis. Understanding how lid mutations affect lipases’ function is important for designing improved variants. Lipases’ function has...

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Detalles Bibliográficos
Autores principales: Iversen, Josephine F., Bohr, Søren S.-R., Pinholt, Henrik D., Moses, Matias E., Iversen, Lars, Christensen, Sune M., Hatzakis, Nikos S., Zhang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135605/
https://www.ncbi.nlm.nih.gov/pubmed/37189378
http://dx.doi.org/10.3390/biom13040631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135605/
https://www.ncbi.nlm.nih.gov/pubmed/37189378
http://dx.doi.org/10.3390/biom13040631

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