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Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders

Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing,...

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Autores principales: Hofmann, Elisabeth, Fink, Julia, Pignet, Anna-Lisa, Schwarz, Anna, Schellnegger, Marlies, Nischwitz, Sebastian P., Holzer-Geissler, Judith C. J., Kamolz, Lars-Peter, Kotzbeck, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135654/
https://www.ncbi.nlm.nih.gov/pubmed/37189674
http://dx.doi.org/10.3390/biomedicines11041056
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author Hofmann, Elisabeth
Fink, Julia
Pignet, Anna-Lisa
Schwarz, Anna
Schellnegger, Marlies
Nischwitz, Sebastian P.
Holzer-Geissler, Judith C. J.
Kamolz, Lars-Peter
Kotzbeck, Petra
author_facet Hofmann, Elisabeth
Fink, Julia
Pignet, Anna-Lisa
Schwarz, Anna
Schellnegger, Marlies
Nischwitz, Sebastian P.
Holzer-Geissler, Judith C. J.
Kamolz, Lars-Peter
Kotzbeck, Petra
author_sort Hofmann, Elisabeth
collection PubMed
description Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing, skin diseases, and the exploration of treatment options. However, in addition to ethical concerns, anatomical and physiological inter-species differences often influence the translatability of animal-based studies. Human in vitro skin models, which include essential cellular and structural components for wound healing analyses, would improve the translatability of results and reduce animal experiments during the preclinical evaluation of novel therapy approaches. In this review, we summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting.
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spelling pubmed-101356542023-04-28 Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders Hofmann, Elisabeth Fink, Julia Pignet, Anna-Lisa Schwarz, Anna Schellnegger, Marlies Nischwitz, Sebastian P. Holzer-Geissler, Judith C. J. Kamolz, Lars-Peter Kotzbeck, Petra Biomedicines Review Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing, skin diseases, and the exploration of treatment options. However, in addition to ethical concerns, anatomical and physiological inter-species differences often influence the translatability of animal-based studies. Human in vitro skin models, which include essential cellular and structural components for wound healing analyses, would improve the translatability of results and reduce animal experiments during the preclinical evaluation of novel therapy approaches. In this review, we summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting. MDPI 2023-03-30 /pmc/articles/PMC10135654/ /pubmed/37189674 http://dx.doi.org/10.3390/biomedicines11041056 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hofmann, Elisabeth
Fink, Julia
Pignet, Anna-Lisa
Schwarz, Anna
Schellnegger, Marlies
Nischwitz, Sebastian P.
Holzer-Geissler, Judith C. J.
Kamolz, Lars-Peter
Kotzbeck, Petra
Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
title Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
title_full Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
title_fullStr Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
title_full_unstemmed Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
title_short Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
title_sort human in vitro skin models for wound healing and wound healing disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135654/
https://www.ncbi.nlm.nih.gov/pubmed/37189674
http://dx.doi.org/10.3390/biomedicines11041056
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