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Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135654/ https://www.ncbi.nlm.nih.gov/pubmed/37189674 http://dx.doi.org/10.3390/biomedicines11041056 |
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author | Hofmann, Elisabeth Fink, Julia Pignet, Anna-Lisa Schwarz, Anna Schellnegger, Marlies Nischwitz, Sebastian P. Holzer-Geissler, Judith C. J. Kamolz, Lars-Peter Kotzbeck, Petra |
author_facet | Hofmann, Elisabeth Fink, Julia Pignet, Anna-Lisa Schwarz, Anna Schellnegger, Marlies Nischwitz, Sebastian P. Holzer-Geissler, Judith C. J. Kamolz, Lars-Peter Kotzbeck, Petra |
author_sort | Hofmann, Elisabeth |
collection | PubMed |
description | Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing, skin diseases, and the exploration of treatment options. However, in addition to ethical concerns, anatomical and physiological inter-species differences often influence the translatability of animal-based studies. Human in vitro skin models, which include essential cellular and structural components for wound healing analyses, would improve the translatability of results and reduce animal experiments during the preclinical evaluation of novel therapy approaches. In this review, we summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting. |
format | Online Article Text |
id | pubmed-10135654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101356542023-04-28 Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders Hofmann, Elisabeth Fink, Julia Pignet, Anna-Lisa Schwarz, Anna Schellnegger, Marlies Nischwitz, Sebastian P. Holzer-Geissler, Judith C. J. Kamolz, Lars-Peter Kotzbeck, Petra Biomedicines Review Skin wound healing is essential to health and survival. Consequently, high amounts of research effort have been put into investigating the cellular and molecular components involved in the wound healing process. The use of animal experiments has contributed greatly to the knowledge of wound healing, skin diseases, and the exploration of treatment options. However, in addition to ethical concerns, anatomical and physiological inter-species differences often influence the translatability of animal-based studies. Human in vitro skin models, which include essential cellular and structural components for wound healing analyses, would improve the translatability of results and reduce animal experiments during the preclinical evaluation of novel therapy approaches. In this review, we summarize in vitro approaches, which are used to study wound healing as well as wound healing-pathologies such as chronic wounds, keloids, and hypertrophic scars in a human setting. MDPI 2023-03-30 /pmc/articles/PMC10135654/ /pubmed/37189674 http://dx.doi.org/10.3390/biomedicines11041056 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hofmann, Elisabeth Fink, Julia Pignet, Anna-Lisa Schwarz, Anna Schellnegger, Marlies Nischwitz, Sebastian P. Holzer-Geissler, Judith C. J. Kamolz, Lars-Peter Kotzbeck, Petra Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders |
title | Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders |
title_full | Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders |
title_fullStr | Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders |
title_full_unstemmed | Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders |
title_short | Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders |
title_sort | human in vitro skin models for wound healing and wound healing disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135654/ https://www.ncbi.nlm.nih.gov/pubmed/37189674 http://dx.doi.org/10.3390/biomedicines11041056 |
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