A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia

This narrative review summarizes the current knowledge of the genetic and epigenetic contributions to the development of fibromyalgia (FM). Although there is no single gene that results in the development of FM, this study reveals that certain polymorphisms in genes involved in the catecholaminergic...

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Autores principales: Ovrom, Erik A., Mostert, Karson A., Khakhkhar, Shivani, McKee, Daniel P., Yang, Padao, Her, Yeng F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135661/
https://www.ncbi.nlm.nih.gov/pubmed/37189737
http://dx.doi.org/10.3390/biomedicines11041119
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author Ovrom, Erik A.
Mostert, Karson A.
Khakhkhar, Shivani
McKee, Daniel P.
Yang, Padao
Her, Yeng F.
author_facet Ovrom, Erik A.
Mostert, Karson A.
Khakhkhar, Shivani
McKee, Daniel P.
Yang, Padao
Her, Yeng F.
author_sort Ovrom, Erik A.
collection PubMed
description This narrative review summarizes the current knowledge of the genetic and epigenetic contributions to the development of fibromyalgia (FM). Although there is no single gene that results in the development of FM, this study reveals that certain polymorphisms in genes involved in the catecholaminergic pathway, the serotonergic pathway, pain processing, oxidative stress, and inflammation may influence susceptibility to FM and the severity of its symptoms. Furthermore, epigenetic changes at the DNA level may lead to the development of FM. Likewise, microRNAs may impact the expression of certain proteins that lead to the worsening of FM-associated symptoms.
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spelling pubmed-101356612023-04-28 A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia Ovrom, Erik A. Mostert, Karson A. Khakhkhar, Shivani McKee, Daniel P. Yang, Padao Her, Yeng F. Biomedicines Review This narrative review summarizes the current knowledge of the genetic and epigenetic contributions to the development of fibromyalgia (FM). Although there is no single gene that results in the development of FM, this study reveals that certain polymorphisms in genes involved in the catecholaminergic pathway, the serotonergic pathway, pain processing, oxidative stress, and inflammation may influence susceptibility to FM and the severity of its symptoms. Furthermore, epigenetic changes at the DNA level may lead to the development of FM. Likewise, microRNAs may impact the expression of certain proteins that lead to the worsening of FM-associated symptoms. MDPI 2023-04-07 /pmc/articles/PMC10135661/ /pubmed/37189737 http://dx.doi.org/10.3390/biomedicines11041119 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ovrom, Erik A.
Mostert, Karson A.
Khakhkhar, Shivani
McKee, Daniel P.
Yang, Padao
Her, Yeng F.
A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia
title A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia
title_full A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia
title_fullStr A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia
title_full_unstemmed A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia
title_short A Comprehensive Review of the Genetic and Epigenetic Contributions to the Development of Fibromyalgia
title_sort comprehensive review of the genetic and epigenetic contributions to the development of fibromyalgia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135661/
https://www.ncbi.nlm.nih.gov/pubmed/37189737
http://dx.doi.org/10.3390/biomedicines11041119
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