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State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis
Identifying target microRNAs (miRNAs) might serve as a basis for developing advanced therapies for Parkinson’s disease (PD) and Alzheimer’s disease. This review aims to identify the main therapeutic targets of miRNAs that can potentially act in Parkinson’s and Alzheimer’s diseases. The publication r...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135663/ https://www.ncbi.nlm.nih.gov/pubmed/37189731 http://dx.doi.org/10.3390/biomedicines11041113 |
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author | Zotarelli-Filho, Idiberto José Mogharbel, Bassam Felipe Irioda, Ana Carolina Stricker, Priscila Elias Ferreira de Oliveira, Nathalia Barth Saçaki, Claudia Sayuri Perussolo, Maiara Carolina da Rosa, Nádia Nascimento Lührs, Larissa Dziedzic, Dilcele Silva Moreira Vaz, Rogério Saad de Carvalho, Katherine Athayde Teixeira |
author_facet | Zotarelli-Filho, Idiberto José Mogharbel, Bassam Felipe Irioda, Ana Carolina Stricker, Priscila Elias Ferreira de Oliveira, Nathalia Barth Saçaki, Claudia Sayuri Perussolo, Maiara Carolina da Rosa, Nádia Nascimento Lührs, Larissa Dziedzic, Dilcele Silva Moreira Vaz, Rogério Saad de Carvalho, Katherine Athayde Teixeira |
author_sort | Zotarelli-Filho, Idiberto José |
collection | PubMed |
description | Identifying target microRNAs (miRNAs) might serve as a basis for developing advanced therapies for Parkinson’s disease (PD) and Alzheimer’s disease. This review aims to identify the main therapeutic targets of miRNAs that can potentially act in Parkinson’s and Alzheimer’s diseases. The publication research was conducted from May 2021 to March 2022, selected from Scopus, PubMed, Embase, OVID, Science Direct, LILACS, and EBSCO. A total of 25 studies were selected from 1549 studies evaluated. The total number of miRNAs as therapeutic targets evidenced was 90 for AD and 54 for PD. An average detection accuracy of above 84% for the miRNAs was observed in the selected studies of AD and PD. The major signatures were miR-26b-5p, miR-615-3p, miR-4722-5p, miR23a-3p, and miR-27b-3p for AD and miR-374a-5p for PD. Six miRNAs of intersection were found between AD and PD. This article identified the main microRNAs as selective biomarkers for diagnosing PD and AD and therapeutic targets through a systematic review and meta-analysis. This article can act as a microRNA guideline for laboratory research and pharmaceutical industries for treating Alzheimer’s and Parkinson’s diseases and offers the opportunity to evaluate therapeutic interventions earlier in the disease process. |
format | Online Article Text |
id | pubmed-10135663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101356632023-04-28 State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis Zotarelli-Filho, Idiberto José Mogharbel, Bassam Felipe Irioda, Ana Carolina Stricker, Priscila Elias Ferreira de Oliveira, Nathalia Barth Saçaki, Claudia Sayuri Perussolo, Maiara Carolina da Rosa, Nádia Nascimento Lührs, Larissa Dziedzic, Dilcele Silva Moreira Vaz, Rogério Saad de Carvalho, Katherine Athayde Teixeira Biomedicines Systematic Review Identifying target microRNAs (miRNAs) might serve as a basis for developing advanced therapies for Parkinson’s disease (PD) and Alzheimer’s disease. This review aims to identify the main therapeutic targets of miRNAs that can potentially act in Parkinson’s and Alzheimer’s diseases. The publication research was conducted from May 2021 to March 2022, selected from Scopus, PubMed, Embase, OVID, Science Direct, LILACS, and EBSCO. A total of 25 studies were selected from 1549 studies evaluated. The total number of miRNAs as therapeutic targets evidenced was 90 for AD and 54 for PD. An average detection accuracy of above 84% for the miRNAs was observed in the selected studies of AD and PD. The major signatures were miR-26b-5p, miR-615-3p, miR-4722-5p, miR23a-3p, and miR-27b-3p for AD and miR-374a-5p for PD. Six miRNAs of intersection were found between AD and PD. This article identified the main microRNAs as selective biomarkers for diagnosing PD and AD and therapeutic targets through a systematic review and meta-analysis. This article can act as a microRNA guideline for laboratory research and pharmaceutical industries for treating Alzheimer’s and Parkinson’s diseases and offers the opportunity to evaluate therapeutic interventions earlier in the disease process. MDPI 2023-04-07 /pmc/articles/PMC10135663/ /pubmed/37189731 http://dx.doi.org/10.3390/biomedicines11041113 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Zotarelli-Filho, Idiberto José Mogharbel, Bassam Felipe Irioda, Ana Carolina Stricker, Priscila Elias Ferreira de Oliveira, Nathalia Barth Saçaki, Claudia Sayuri Perussolo, Maiara Carolina da Rosa, Nádia Nascimento Lührs, Larissa Dziedzic, Dilcele Silva Moreira Vaz, Rogério Saad de Carvalho, Katherine Athayde Teixeira State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis |
title | State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis |
title_full | State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis |
title_fullStr | State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis |
title_full_unstemmed | State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis |
title_short | State of the Art of microRNAs Signatures as Biomarkers and Therapeutic Targets in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis |
title_sort | state of the art of micrornas signatures as biomarkers and therapeutic targets in parkinson’s and alzheimer’s diseases: a systematic review and meta-analysis |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135663/ https://www.ncbi.nlm.nih.gov/pubmed/37189731 http://dx.doi.org/10.3390/biomedicines11041113 |
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