Novel Biomarkers of Diabetic Kidney Disease

Diabetic kidney disease (DKD) is a highly prevalent condition worldwide. It represents one of the most common complications arising from diabetes mellitus (DM) and is the leading cause of end-stage kidney disease (ESKD). Its development involves three fundamental components: the hemodynamic, metabol...

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Detalles Bibliográficos
Autores principales: Rico-Fontalvo, Jorge, Aroca-Martínez, Gustavo, Daza-Arnedo, Rodrigo, Cabrales, José, Rodríguez-Yanez, Tomás, Cardona-Blanco, María, Montejo-Hernández, Juan, Rodelo Barrios, Dairo, Patiño-Patiño, Jhonny, Osorio Rodríguez, Elber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135955/
https://www.ncbi.nlm.nih.gov/pubmed/37189380
http://dx.doi.org/10.3390/biom13040633
Descripción
Sumario:Diabetic kidney disease (DKD) is a highly prevalent condition worldwide. It represents one of the most common complications arising from diabetes mellitus (DM) and is the leading cause of end-stage kidney disease (ESKD). Its development involves three fundamental components: the hemodynamic, metabolic, and inflammatory axes. Clinically, persistent albuminuria in association with a progressive decline in glomerular filtration rate (GFR) defines this disease. However, as these alterations are not specific to DKD, there is a need to discuss novel biomarkers arising from its pathogenesis which may aid in the diagnosis, follow-up, therapeutic response, and prognosis of the disease.

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