Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA(A) Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor

The positive allosteric modulators (PAMs) of the α7 nicotinic receptor N-(5-Cl-2-hydroxyphenyl)-N′-[2-Cl-5-(trifluoromethyl)phenyl]-urea (NS-1738) and (E)-3-(furan-2-yl)-N-(p-tolyl)-acrylamide (PAM-2) potentiate the α1β2γ2L GABA(A) receptor through interactions with the classic anesthetic binding si...

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Detalles Bibliográficos
Autores principales: Pierce, Spencer R., Germann, Allison L., Xu, Sophia Q., Menon, Saumith L., Ortells, Marcelo O., Arias, Hugo R., Akk, Gustav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135968/
https://www.ncbi.nlm.nih.gov/pubmed/37189445
http://dx.doi.org/10.3390/biom13040698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135968/
https://www.ncbi.nlm.nih.gov/pubmed/37189445
http://dx.doi.org/10.3390/biom13040698

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