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Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA(A) Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor
The positive allosteric modulators (PAMs) of the α7 nicotinic receptor N-(5-Cl-2-hydroxyphenyl)-N′-[2-Cl-5-(trifluoromethyl)phenyl]-urea (NS-1738) and (E)-3-(furan-2-yl)-N-(p-tolyl)-acrylamide (PAM-2) potentiate the α1β2γ2L GABA(A) receptor through interactions with the classic anesthetic binding si...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135968/ https://www.ncbi.nlm.nih.gov/pubmed/37189445 http://dx.doi.org/10.3390/biom13040698 |