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Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study
During the COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOC) with specific characteristics have emerged and spread worldwide. At the same time, clinicians routinely evaluate the results of certain blood tests upon patient admission as well as during hospitalization to assess disease...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135992/ https://www.ncbi.nlm.nih.gov/pubmed/37189760 http://dx.doi.org/10.3390/biomedicines11041143 |
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author | Meletis, Georgios Tychala, Areti Ntritsos, Georgios Verrou, Eleni Savvidou, Filio Dermitzakis, Iasonas Chatzidimitriou, Anastasia Gkeka, Ioanna Fyntanidou, Barbara Gkarmiri, Sofia Tzallas, Alexandros T. Protonotariou, Efthymia Makedou, Kali Tsalikakis, Dimitrios G. Skoura, Lemonia |
author_facet | Meletis, Georgios Tychala, Areti Ntritsos, Georgios Verrou, Eleni Savvidou, Filio Dermitzakis, Iasonas Chatzidimitriou, Anastasia Gkeka, Ioanna Fyntanidou, Barbara Gkarmiri, Sofia Tzallas, Alexandros T. Protonotariou, Efthymia Makedou, Kali Tsalikakis, Dimitrios G. Skoura, Lemonia |
author_sort | Meletis, Georgios |
collection | PubMed |
description | During the COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOC) with specific characteristics have emerged and spread worldwide. At the same time, clinicians routinely evaluate the results of certain blood tests upon patient admission as well as during hospitalization to assess disease severity and the overall patient status. In the present study, we searched for significant cell blood count and biomarker differences among patients affected with the Alpha, Delta and Omicron VOCs at admission. Data from 330 patients were retrieved regarding age, gender, VOC, cell blood count results (WBC, Neut%, Lymph%, Ig%, PLT), common biomarkers (D-dimers, urea, creatinine, SGOT, SGPT, CRP, IL-6, suPAR), ICU admission and death. Statistical analyses were performed using ANOVA, the Kruskal–Wallis test, two-way ANOVA, Chi-square, T-test, the Mann–Whitney test and logistic regression was performed where appropriate using SPSS v.28 and STATA 14. Age and VOC were significantly associated with hospitalization, whereas significant differences among VOC groups were found for WBC, PLT, Neut%, IL-6, creatinine, CRP, D-dimers and suPAR. Our analyses showed that throughout the current pandemic, not only the SARS-CoV-2 VOCs but also the laboratory parameters that are used to evaluate the patient’s status at admission are subject to changes. |
format | Online Article Text |
id | pubmed-10135992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101359922023-04-28 Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study Meletis, Georgios Tychala, Areti Ntritsos, Georgios Verrou, Eleni Savvidou, Filio Dermitzakis, Iasonas Chatzidimitriou, Anastasia Gkeka, Ioanna Fyntanidou, Barbara Gkarmiri, Sofia Tzallas, Alexandros T. Protonotariou, Efthymia Makedou, Kali Tsalikakis, Dimitrios G. Skoura, Lemonia Biomedicines Article During the COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOC) with specific characteristics have emerged and spread worldwide. At the same time, clinicians routinely evaluate the results of certain blood tests upon patient admission as well as during hospitalization to assess disease severity and the overall patient status. In the present study, we searched for significant cell blood count and biomarker differences among patients affected with the Alpha, Delta and Omicron VOCs at admission. Data from 330 patients were retrieved regarding age, gender, VOC, cell blood count results (WBC, Neut%, Lymph%, Ig%, PLT), common biomarkers (D-dimers, urea, creatinine, SGOT, SGPT, CRP, IL-6, suPAR), ICU admission and death. Statistical analyses were performed using ANOVA, the Kruskal–Wallis test, two-way ANOVA, Chi-square, T-test, the Mann–Whitney test and logistic regression was performed where appropriate using SPSS v.28 and STATA 14. Age and VOC were significantly associated with hospitalization, whereas significant differences among VOC groups were found for WBC, PLT, Neut%, IL-6, creatinine, CRP, D-dimers and suPAR. Our analyses showed that throughout the current pandemic, not only the SARS-CoV-2 VOCs but also the laboratory parameters that are used to evaluate the patient’s status at admission are subject to changes. MDPI 2023-04-10 /pmc/articles/PMC10135992/ /pubmed/37189760 http://dx.doi.org/10.3390/biomedicines11041143 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Meletis, Georgios Tychala, Areti Ntritsos, Georgios Verrou, Eleni Savvidou, Filio Dermitzakis, Iasonas Chatzidimitriou, Anastasia Gkeka, Ioanna Fyntanidou, Barbara Gkarmiri, Sofia Tzallas, Alexandros T. Protonotariou, Efthymia Makedou, Kali Tsalikakis, Dimitrios G. Skoura, Lemonia Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study |
title | Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study |
title_full | Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study |
title_fullStr | Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study |
title_full_unstemmed | Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study |
title_short | Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study |
title_sort | variant-related differences in laboratory biomarkers among patients affected with alpha, delta and omicron: a retrospective whole viral genome sequencing and hospital-setting cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135992/ https://www.ncbi.nlm.nih.gov/pubmed/37189760 http://dx.doi.org/10.3390/biomedicines11041143 |
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