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Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study

During the COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOC) with specific characteristics have emerged and spread worldwide. At the same time, clinicians routinely evaluate the results of certain blood tests upon patient admission as well as during hospitalization to assess disease...

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Autores principales: Meletis, Georgios, Tychala, Areti, Ntritsos, Georgios, Verrou, Eleni, Savvidou, Filio, Dermitzakis, Iasonas, Chatzidimitriou, Anastasia, Gkeka, Ioanna, Fyntanidou, Barbara, Gkarmiri, Sofia, Tzallas, Alexandros T., Protonotariou, Efthymia, Makedou, Kali, Tsalikakis, Dimitrios G., Skoura, Lemonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135992/
https://www.ncbi.nlm.nih.gov/pubmed/37189760
http://dx.doi.org/10.3390/biomedicines11041143
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author Meletis, Georgios
Tychala, Areti
Ntritsos, Georgios
Verrou, Eleni
Savvidou, Filio
Dermitzakis, Iasonas
Chatzidimitriou, Anastasia
Gkeka, Ioanna
Fyntanidou, Barbara
Gkarmiri, Sofia
Tzallas, Alexandros T.
Protonotariou, Efthymia
Makedou, Kali
Tsalikakis, Dimitrios G.
Skoura, Lemonia
author_facet Meletis, Georgios
Tychala, Areti
Ntritsos, Georgios
Verrou, Eleni
Savvidou, Filio
Dermitzakis, Iasonas
Chatzidimitriou, Anastasia
Gkeka, Ioanna
Fyntanidou, Barbara
Gkarmiri, Sofia
Tzallas, Alexandros T.
Protonotariou, Efthymia
Makedou, Kali
Tsalikakis, Dimitrios G.
Skoura, Lemonia
author_sort Meletis, Georgios
collection PubMed
description During the COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOC) with specific characteristics have emerged and spread worldwide. At the same time, clinicians routinely evaluate the results of certain blood tests upon patient admission as well as during hospitalization to assess disease severity and the overall patient status. In the present study, we searched for significant cell blood count and biomarker differences among patients affected with the Alpha, Delta and Omicron VOCs at admission. Data from 330 patients were retrieved regarding age, gender, VOC, cell blood count results (WBC, Neut%, Lymph%, Ig%, PLT), common biomarkers (D-dimers, urea, creatinine, SGOT, SGPT, CRP, IL-6, suPAR), ICU admission and death. Statistical analyses were performed using ANOVA, the Kruskal–Wallis test, two-way ANOVA, Chi-square, T-test, the Mann–Whitney test and logistic regression was performed where appropriate using SPSS v.28 and STATA 14. Age and VOC were significantly associated with hospitalization, whereas significant differences among VOC groups were found for WBC, PLT, Neut%, IL-6, creatinine, CRP, D-dimers and suPAR. Our analyses showed that throughout the current pandemic, not only the SARS-CoV-2 VOCs but also the laboratory parameters that are used to evaluate the patient’s status at admission are subject to changes.
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spelling pubmed-101359922023-04-28 Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study Meletis, Georgios Tychala, Areti Ntritsos, Georgios Verrou, Eleni Savvidou, Filio Dermitzakis, Iasonas Chatzidimitriou, Anastasia Gkeka, Ioanna Fyntanidou, Barbara Gkarmiri, Sofia Tzallas, Alexandros T. Protonotariou, Efthymia Makedou, Kali Tsalikakis, Dimitrios G. Skoura, Lemonia Biomedicines Article During the COVID-19 pandemic, different SARS-CoV-2 variants of concern (VOC) with specific characteristics have emerged and spread worldwide. At the same time, clinicians routinely evaluate the results of certain blood tests upon patient admission as well as during hospitalization to assess disease severity and the overall patient status. In the present study, we searched for significant cell blood count and biomarker differences among patients affected with the Alpha, Delta and Omicron VOCs at admission. Data from 330 patients were retrieved regarding age, gender, VOC, cell blood count results (WBC, Neut%, Lymph%, Ig%, PLT), common biomarkers (D-dimers, urea, creatinine, SGOT, SGPT, CRP, IL-6, suPAR), ICU admission and death. Statistical analyses were performed using ANOVA, the Kruskal–Wallis test, two-way ANOVA, Chi-square, T-test, the Mann–Whitney test and logistic regression was performed where appropriate using SPSS v.28 and STATA 14. Age and VOC were significantly associated with hospitalization, whereas significant differences among VOC groups were found for WBC, PLT, Neut%, IL-6, creatinine, CRP, D-dimers and suPAR. Our analyses showed that throughout the current pandemic, not only the SARS-CoV-2 VOCs but also the laboratory parameters that are used to evaluate the patient’s status at admission are subject to changes. MDPI 2023-04-10 /pmc/articles/PMC10135992/ /pubmed/37189760 http://dx.doi.org/10.3390/biomedicines11041143 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meletis, Georgios
Tychala, Areti
Ntritsos, Georgios
Verrou, Eleni
Savvidou, Filio
Dermitzakis, Iasonas
Chatzidimitriou, Anastasia
Gkeka, Ioanna
Fyntanidou, Barbara
Gkarmiri, Sofia
Tzallas, Alexandros T.
Protonotariou, Efthymia
Makedou, Kali
Tsalikakis, Dimitrios G.
Skoura, Lemonia
Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study
title Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study
title_full Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study
title_fullStr Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study
title_full_unstemmed Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study
title_short Variant-Related Differences in Laboratory Biomarkers among Patients Affected with Alpha, Delta and Omicron: A Retrospective Whole Viral Genome Sequencing and Hospital-Setting Cohort Study
title_sort variant-related differences in laboratory biomarkers among patients affected with alpha, delta and omicron: a retrospective whole viral genome sequencing and hospital-setting cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135992/
https://www.ncbi.nlm.nih.gov/pubmed/37189760
http://dx.doi.org/10.3390/biomedicines11041143
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