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Green Synthesis and Antiproliferative Activity of Gold Nanoparticles of a Controlled Size and Shape Obtained Using Shock Wave Extracts from Amphipterygium adstringens

In this study, green chemistry was used as a tool to obtain gold nanoparticles using Amphipterygium adstringens extracts as a synthesis medium. Green ethanolic and aqueous extracts were obtained using ultrasound and shock wave-assisted extraction. Gold nanoparticles with sizes ranging between 100 an...

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Autores principales: Torres-Ortiz, Daniela, García-Alcocer, Guadalupe, Loske, Achim M., Fernández, Francisco, Becerra-Becerra, Edgardo, Esparza, Rodrigo, Gonzalez-Reyna, Marlen Alexis, Estevez, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136038/
https://www.ncbi.nlm.nih.gov/pubmed/37106624
http://dx.doi.org/10.3390/bioengineering10040437
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author Torres-Ortiz, Daniela
García-Alcocer, Guadalupe
Loske, Achim M.
Fernández, Francisco
Becerra-Becerra, Edgardo
Esparza, Rodrigo
Gonzalez-Reyna, Marlen Alexis
Estevez, Miriam
author_facet Torres-Ortiz, Daniela
García-Alcocer, Guadalupe
Loske, Achim M.
Fernández, Francisco
Becerra-Becerra, Edgardo
Esparza, Rodrigo
Gonzalez-Reyna, Marlen Alexis
Estevez, Miriam
author_sort Torres-Ortiz, Daniela
collection PubMed
description In this study, green chemistry was used as a tool to obtain gold nanoparticles using Amphipterygium adstringens extracts as a synthesis medium. Green ethanolic and aqueous extracts were obtained using ultrasound and shock wave-assisted extraction. Gold nanoparticles with sizes ranging between 100 and 150 nm were obtained with ultrasound aqueous extract. Interestingly, homogeneous quasi-spherical gold nanoparticles with sizes between 50 and 100 nm were achieved with shock wave aqueous-ethanolic extracts. Furthermore, 10 nm gold nanoparticles were obtained by the traditional methanolic macerate extraction method. The physicochemical characteristics, morphology, size, stability, and Z potential of the nanoparticles were determined using microscopic and spectroscopic techniques. The viability assay in leukemia cells (Jurkat) was performed using two different sets of gold nanoparticles, with final IC(50) values of 87 µM and 94.7 µM, reaching a maximum cell viability decrease of 80% The results do not indicate a significant difference between the cytotoxic effects produced by the gold nanoparticles synthesized in this study and vincristine on normal lymphoblasts (CRL-1991).
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spelling pubmed-101360382023-04-28 Green Synthesis and Antiproliferative Activity of Gold Nanoparticles of a Controlled Size and Shape Obtained Using Shock Wave Extracts from Amphipterygium adstringens Torres-Ortiz, Daniela García-Alcocer, Guadalupe Loske, Achim M. Fernández, Francisco Becerra-Becerra, Edgardo Esparza, Rodrigo Gonzalez-Reyna, Marlen Alexis Estevez, Miriam Bioengineering (Basel) Article In this study, green chemistry was used as a tool to obtain gold nanoparticles using Amphipterygium adstringens extracts as a synthesis medium. Green ethanolic and aqueous extracts were obtained using ultrasound and shock wave-assisted extraction. Gold nanoparticles with sizes ranging between 100 and 150 nm were obtained with ultrasound aqueous extract. Interestingly, homogeneous quasi-spherical gold nanoparticles with sizes between 50 and 100 nm were achieved with shock wave aqueous-ethanolic extracts. Furthermore, 10 nm gold nanoparticles were obtained by the traditional methanolic macerate extraction method. The physicochemical characteristics, morphology, size, stability, and Z potential of the nanoparticles were determined using microscopic and spectroscopic techniques. The viability assay in leukemia cells (Jurkat) was performed using two different sets of gold nanoparticles, with final IC(50) values of 87 µM and 94.7 µM, reaching a maximum cell viability decrease of 80% The results do not indicate a significant difference between the cytotoxic effects produced by the gold nanoparticles synthesized in this study and vincristine on normal lymphoblasts (CRL-1991). MDPI 2023-03-30 /pmc/articles/PMC10136038/ /pubmed/37106624 http://dx.doi.org/10.3390/bioengineering10040437 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torres-Ortiz, Daniela
García-Alcocer, Guadalupe
Loske, Achim M.
Fernández, Francisco
Becerra-Becerra, Edgardo
Esparza, Rodrigo
Gonzalez-Reyna, Marlen Alexis
Estevez, Miriam
Green Synthesis and Antiproliferative Activity of Gold Nanoparticles of a Controlled Size and Shape Obtained Using Shock Wave Extracts from Amphipterygium adstringens
title Green Synthesis and Antiproliferative Activity of Gold Nanoparticles of a Controlled Size and Shape Obtained Using Shock Wave Extracts from Amphipterygium adstringens
title_full Green Synthesis and Antiproliferative Activity of Gold Nanoparticles of a Controlled Size and Shape Obtained Using Shock Wave Extracts from Amphipterygium adstringens
title_fullStr Green Synthesis and Antiproliferative Activity of Gold Nanoparticles of a Controlled Size and Shape Obtained Using Shock Wave Extracts from Amphipterygium adstringens
title_full_unstemmed Green Synthesis and Antiproliferative Activity of Gold Nanoparticles of a Controlled Size and Shape Obtained Using Shock Wave Extracts from Amphipterygium adstringens
title_short Green Synthesis and Antiproliferative Activity of Gold Nanoparticles of a Controlled Size and Shape Obtained Using Shock Wave Extracts from Amphipterygium adstringens
title_sort green synthesis and antiproliferative activity of gold nanoparticles of a controlled size and shape obtained using shock wave extracts from amphipterygium adstringens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136038/
https://www.ncbi.nlm.nih.gov/pubmed/37106624
http://dx.doi.org/10.3390/bioengineering10040437
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