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Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes

Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer’s disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart disease and stroke), type 2 diabetes, hypertension, chronic kidney disease, stroke, and infectious...

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Autores principales: Grant, William B., Al Anouti, Fatme, Boucher, Barbara J., Fakhoury, Hana M. A., Moukayed, Meis, Pilz, Stefan, Al-Daghri, Nasser M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136066/
https://www.ncbi.nlm.nih.gov/pubmed/37189612
http://dx.doi.org/10.3390/biomedicines11040994
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author Grant, William B.
Al Anouti, Fatme
Boucher, Barbara J.
Fakhoury, Hana M. A.
Moukayed, Meis
Pilz, Stefan
Al-Daghri, Nasser M.
author_facet Grant, William B.
Al Anouti, Fatme
Boucher, Barbara J.
Fakhoury, Hana M. A.
Moukayed, Meis
Pilz, Stefan
Al-Daghri, Nasser M.
author_sort Grant, William B.
collection PubMed
description Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer’s disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart disease and stroke), type 2 diabetes, hypertension, chronic kidney disease, stroke, and infectious diseases such as acute respiratory tract diseases, COVID-19, influenza, and pneumonia, as well as adverse pregnancy outcomes. The respective evidence is based on ecological and observational studies, randomized controlled trials, mechanistic studies, and Mendelian randomization studies. However, randomized controlled trials on vitamin D supplementation have largely failed to show benefits, probably due to poor design and analysis. In this work, we aim to use the best available evidence on the potential beneficial effects of vitamin D to estimate the expected reduction in incidence and mortality rates of vitamin D-related diseases in the Kingdom of Saudi Arabia and the United Arab Emirates if minimum serum 25(OH)D concentrations were to be raised to 30 ng/mL. Estimated reductions by 25% for myocardial infarction incidence, 35% for stroke incidence, 20 to 35% for cardiovascular disease mortality, and 35% for cancer mortality rates depicted a promising potential for raising serum 25(OH)D. Methods to increase serum 25(OH)D concentrations at the population level could include food fortification with vitamin D(3), vitamin D supplementation, improved dietary vitamin D intake, and sensible sun exposure.
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spelling pubmed-101360662023-04-28 Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes Grant, William B. Al Anouti, Fatme Boucher, Barbara J. Fakhoury, Hana M. A. Moukayed, Meis Pilz, Stefan Al-Daghri, Nasser M. Biomedicines Review Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer’s disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart disease and stroke), type 2 diabetes, hypertension, chronic kidney disease, stroke, and infectious diseases such as acute respiratory tract diseases, COVID-19, influenza, and pneumonia, as well as adverse pregnancy outcomes. The respective evidence is based on ecological and observational studies, randomized controlled trials, mechanistic studies, and Mendelian randomization studies. However, randomized controlled trials on vitamin D supplementation have largely failed to show benefits, probably due to poor design and analysis. In this work, we aim to use the best available evidence on the potential beneficial effects of vitamin D to estimate the expected reduction in incidence and mortality rates of vitamin D-related diseases in the Kingdom of Saudi Arabia and the United Arab Emirates if minimum serum 25(OH)D concentrations were to be raised to 30 ng/mL. Estimated reductions by 25% for myocardial infarction incidence, 35% for stroke incidence, 20 to 35% for cardiovascular disease mortality, and 35% for cancer mortality rates depicted a promising potential for raising serum 25(OH)D. Methods to increase serum 25(OH)D concentrations at the population level could include food fortification with vitamin D(3), vitamin D supplementation, improved dietary vitamin D intake, and sensible sun exposure. MDPI 2023-03-23 /pmc/articles/PMC10136066/ /pubmed/37189612 http://dx.doi.org/10.3390/biomedicines11040994 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grant, William B.
Al Anouti, Fatme
Boucher, Barbara J.
Fakhoury, Hana M. A.
Moukayed, Meis
Pilz, Stefan
Al-Daghri, Nasser M.
Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
title Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
title_full Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
title_fullStr Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
title_full_unstemmed Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
title_short Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
title_sort evidence that increasing serum 25(oh)d concentrations to 30 ng/ml in the kingdom of saudi arabia and the united arab emirates could greatly improve health outcomes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136066/
https://www.ncbi.nlm.nih.gov/pubmed/37189612
http://dx.doi.org/10.3390/biomedicines11040994
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