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β-Glucosidase and Its Application in Bioconversion of Ginsenosides in Panax ginseng

Ginsenosides are a group of bioactive compounds isolated from Panax ginseng. Conventional major ginsenosides have a long history of use in traditional medicine for both illness prevention and therapy. Bioconversion processes have the potential to create new and valuable products in pharmaceutical an...

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Autores principales: Tran, Thi Ngoc Anh, Son, Jin-Sung, Awais, Muhammad, Ko, Jae-Heung, Yang, Deok Chun, Jung, Seok-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136122/
https://www.ncbi.nlm.nih.gov/pubmed/37106671
http://dx.doi.org/10.3390/bioengineering10040484
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author Tran, Thi Ngoc Anh
Son, Jin-Sung
Awais, Muhammad
Ko, Jae-Heung
Yang, Deok Chun
Jung, Seok-Kyu
author_facet Tran, Thi Ngoc Anh
Son, Jin-Sung
Awais, Muhammad
Ko, Jae-Heung
Yang, Deok Chun
Jung, Seok-Kyu
author_sort Tran, Thi Ngoc Anh
collection PubMed
description Ginsenosides are a group of bioactive compounds isolated from Panax ginseng. Conventional major ginsenosides have a long history of use in traditional medicine for both illness prevention and therapy. Bioconversion processes have the potential to create new and valuable products in pharmaceutical and biological activities, making them both critical for research and highly economic to implement. This has led to an increase in the number of studies that use major ginsenosides as a precursor to generate minor ones using β-glucosidase. Minor ginsenosides may also have useful properties but are difficult to isolate from raw ginseng because of their scarcity. Bioconversion processes have the potential to create novel minor ginsenosides from the more abundant major ginsenoside precursors in a cost-effective manner. While numerous bioconversion techniques have been developed, an increasing number of studies have reported that β-glucosidase can effectively and specifically generate minor ginsenosides. This paper summarizes the probable bioconversion mechanisms of two protopanaxadiol (PPD) and protopanaxatriol (PPT) types. Other high-efficiency and high-value bioconversion processes using complete proteins isolated from bacterial biomass or recombinant enzymes are also discussed in this article. This paper also discusses the various conversion and analysis methods and their potential applications. Overall, this paper offers theoretical and technical foundations for future studies that will be both scientifically and economically significant.
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spelling pubmed-101361222023-04-28 β-Glucosidase and Its Application in Bioconversion of Ginsenosides in Panax ginseng Tran, Thi Ngoc Anh Son, Jin-Sung Awais, Muhammad Ko, Jae-Heung Yang, Deok Chun Jung, Seok-Kyu Bioengineering (Basel) Review Ginsenosides are a group of bioactive compounds isolated from Panax ginseng. Conventional major ginsenosides have a long history of use in traditional medicine for both illness prevention and therapy. Bioconversion processes have the potential to create new and valuable products in pharmaceutical and biological activities, making them both critical for research and highly economic to implement. This has led to an increase in the number of studies that use major ginsenosides as a precursor to generate minor ones using β-glucosidase. Minor ginsenosides may also have useful properties but are difficult to isolate from raw ginseng because of their scarcity. Bioconversion processes have the potential to create novel minor ginsenosides from the more abundant major ginsenoside precursors in a cost-effective manner. While numerous bioconversion techniques have been developed, an increasing number of studies have reported that β-glucosidase can effectively and specifically generate minor ginsenosides. This paper summarizes the probable bioconversion mechanisms of two protopanaxadiol (PPD) and protopanaxatriol (PPT) types. Other high-efficiency and high-value bioconversion processes using complete proteins isolated from bacterial biomass or recombinant enzymes are also discussed in this article. This paper also discusses the various conversion and analysis methods and their potential applications. Overall, this paper offers theoretical and technical foundations for future studies that will be both scientifically and economically significant. MDPI 2023-04-18 /pmc/articles/PMC10136122/ /pubmed/37106671 http://dx.doi.org/10.3390/bioengineering10040484 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tran, Thi Ngoc Anh
Son, Jin-Sung
Awais, Muhammad
Ko, Jae-Heung
Yang, Deok Chun
Jung, Seok-Kyu
β-Glucosidase and Its Application in Bioconversion of Ginsenosides in Panax ginseng
title β-Glucosidase and Its Application in Bioconversion of Ginsenosides in Panax ginseng
title_full β-Glucosidase and Its Application in Bioconversion of Ginsenosides in Panax ginseng
title_fullStr β-Glucosidase and Its Application in Bioconversion of Ginsenosides in Panax ginseng
title_full_unstemmed β-Glucosidase and Its Application in Bioconversion of Ginsenosides in Panax ginseng
title_short β-Glucosidase and Its Application in Bioconversion of Ginsenosides in Panax ginseng
title_sort β-glucosidase and its application in bioconversion of ginsenosides in panax ginseng
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136122/
https://www.ncbi.nlm.nih.gov/pubmed/37106671
http://dx.doi.org/10.3390/bioengineering10040484
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