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HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances

The 70 kDa heat shock proteins (HSP70s) are a group of highly conserved and inducible heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones that are involved in a large variety of cellular protein folding and remodeling processes. HSP70s are found to be over-expr...

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Autores principales: Zhao, Kejia, Zhou, Guanyu, Liu, Yu, Zhang, Jian, Chen, Yaohui, Liu, Lunxu, Zhang, Gao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136146/
https://www.ncbi.nlm.nih.gov/pubmed/37189349
http://dx.doi.org/10.3390/biom13040601
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author Zhao, Kejia
Zhou, Guanyu
Liu, Yu
Zhang, Jian
Chen, Yaohui
Liu, Lunxu
Zhang, Gao
author_facet Zhao, Kejia
Zhou, Guanyu
Liu, Yu
Zhang, Jian
Chen, Yaohui
Liu, Lunxu
Zhang, Gao
author_sort Zhao, Kejia
collection PubMed
description The 70 kDa heat shock proteins (HSP70s) are a group of highly conserved and inducible heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones that are involved in a large variety of cellular protein folding and remodeling processes. HSP70s are found to be over-expressed and may serve as prognostic markers in many types of cancers. HSP70s are also involved in most of the molecular processes of cancer hallmarks as well as the growth and survival of cancer cells. In fact, many effects of HSP70s on cancer cells are not only related to their chaperone activities but rather to their roles in regulating cancer cell signaling. Therefore, a number of drugs directly or indirectly targeting HSP70s, and their co-chaperones have been developed aiming to treat cancer. In this review, we summarized HSP70-related cancer signaling pathways and corresponding key proteins regulated by the family of HSP70s. In addition, we also summarized various treatment approaches and progress of anti-tumor therapy based on targeting HSP70 family proteins.
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spelling pubmed-101361462023-04-28 HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances Zhao, Kejia Zhou, Guanyu Liu, Yu Zhang, Jian Chen, Yaohui Liu, Lunxu Zhang, Gao Biomolecules Review The 70 kDa heat shock proteins (HSP70s) are a group of highly conserved and inducible heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones that are involved in a large variety of cellular protein folding and remodeling processes. HSP70s are found to be over-expressed and may serve as prognostic markers in many types of cancers. HSP70s are also involved in most of the molecular processes of cancer hallmarks as well as the growth and survival of cancer cells. In fact, many effects of HSP70s on cancer cells are not only related to their chaperone activities but rather to their roles in regulating cancer cell signaling. Therefore, a number of drugs directly or indirectly targeting HSP70s, and their co-chaperones have been developed aiming to treat cancer. In this review, we summarized HSP70-related cancer signaling pathways and corresponding key proteins regulated by the family of HSP70s. In addition, we also summarized various treatment approaches and progress of anti-tumor therapy based on targeting HSP70 family proteins. MDPI 2023-03-27 /pmc/articles/PMC10136146/ /pubmed/37189349 http://dx.doi.org/10.3390/biom13040601 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Kejia
Zhou, Guanyu
Liu, Yu
Zhang, Jian
Chen, Yaohui
Liu, Lunxu
Zhang, Gao
HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances
title HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances
title_full HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances
title_fullStr HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances
title_full_unstemmed HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances
title_short HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances
title_sort hsp70 family in cancer: signaling mechanisms and therapeutic advances
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136146/
https://www.ncbi.nlm.nih.gov/pubmed/37189349
http://dx.doi.org/10.3390/biom13040601
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