Cargando…
HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances
The 70 kDa heat shock proteins (HSP70s) are a group of highly conserved and inducible heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones that are involved in a large variety of cellular protein folding and remodeling processes. HSP70s are found to be over-expr...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136146/ https://www.ncbi.nlm.nih.gov/pubmed/37189349 http://dx.doi.org/10.3390/biom13040601 |
_version_ | 1785032146297028608 |
---|---|
author | Zhao, Kejia Zhou, Guanyu Liu, Yu Zhang, Jian Chen, Yaohui Liu, Lunxu Zhang, Gao |
author_facet | Zhao, Kejia Zhou, Guanyu Liu, Yu Zhang, Jian Chen, Yaohui Liu, Lunxu Zhang, Gao |
author_sort | Zhao, Kejia |
collection | PubMed |
description | The 70 kDa heat shock proteins (HSP70s) are a group of highly conserved and inducible heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones that are involved in a large variety of cellular protein folding and remodeling processes. HSP70s are found to be over-expressed and may serve as prognostic markers in many types of cancers. HSP70s are also involved in most of the molecular processes of cancer hallmarks as well as the growth and survival of cancer cells. In fact, many effects of HSP70s on cancer cells are not only related to their chaperone activities but rather to their roles in regulating cancer cell signaling. Therefore, a number of drugs directly or indirectly targeting HSP70s, and their co-chaperones have been developed aiming to treat cancer. In this review, we summarized HSP70-related cancer signaling pathways and corresponding key proteins regulated by the family of HSP70s. In addition, we also summarized various treatment approaches and progress of anti-tumor therapy based on targeting HSP70 family proteins. |
format | Online Article Text |
id | pubmed-10136146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101361462023-04-28 HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances Zhao, Kejia Zhou, Guanyu Liu, Yu Zhang, Jian Chen, Yaohui Liu, Lunxu Zhang, Gao Biomolecules Review The 70 kDa heat shock proteins (HSP70s) are a group of highly conserved and inducible heat shock proteins. One of the main functions of HSP70s is to act as molecular chaperones that are involved in a large variety of cellular protein folding and remodeling processes. HSP70s are found to be over-expressed and may serve as prognostic markers in many types of cancers. HSP70s are also involved in most of the molecular processes of cancer hallmarks as well as the growth and survival of cancer cells. In fact, many effects of HSP70s on cancer cells are not only related to their chaperone activities but rather to their roles in regulating cancer cell signaling. Therefore, a number of drugs directly or indirectly targeting HSP70s, and their co-chaperones have been developed aiming to treat cancer. In this review, we summarized HSP70-related cancer signaling pathways and corresponding key proteins regulated by the family of HSP70s. In addition, we also summarized various treatment approaches and progress of anti-tumor therapy based on targeting HSP70 family proteins. MDPI 2023-03-27 /pmc/articles/PMC10136146/ /pubmed/37189349 http://dx.doi.org/10.3390/biom13040601 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhao, Kejia Zhou, Guanyu Liu, Yu Zhang, Jian Chen, Yaohui Liu, Lunxu Zhang, Gao HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances |
title | HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances |
title_full | HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances |
title_fullStr | HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances |
title_full_unstemmed | HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances |
title_short | HSP70 Family in Cancer: Signaling Mechanisms and Therapeutic Advances |
title_sort | hsp70 family in cancer: signaling mechanisms and therapeutic advances |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136146/ https://www.ncbi.nlm.nih.gov/pubmed/37189349 http://dx.doi.org/10.3390/biom13040601 |
work_keys_str_mv | AT zhaokejia hsp70familyincancersignalingmechanismsandtherapeuticadvances AT zhouguanyu hsp70familyincancersignalingmechanismsandtherapeuticadvances AT liuyu hsp70familyincancersignalingmechanismsandtherapeuticadvances AT zhangjian hsp70familyincancersignalingmechanismsandtherapeuticadvances AT chenyaohui hsp70familyincancersignalingmechanismsandtherapeuticadvances AT liulunxu hsp70familyincancersignalingmechanismsandtherapeuticadvances AT zhanggao hsp70familyincancersignalingmechanismsandtherapeuticadvances |