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The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice

Obesity is a global health issue, in which modifications in gut microbiota composition have a key role. Different therapeutic strategies are being developed in combination with diet and exercise, including the use of plant extracts, such as those obtained from Morus alba L. leaves. Recent studies ha...

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Autores principales: Rodríguez-Sojo, María Jesús, Ruiz-Malagón, Antonio Jesús, Hidalgo-García, Laura, Molina-Tijeras, Jose Alberto, Diez-Echave, Patricia, López-Escanez, Laura, Rosati, Lucrezia, González-Lozano, Elena, Cenis-Cifuentes, Laura, García-García, Jorge, García, Federico, Robles-Vera, Iñaki, Romero, Miguel, Duarte, Juan, Cenis, José Luis, Lozano-Pérez, Antonio Abel, Gálvez, Julio, Rodríguez-Cabezas, María Elena, Rodríguez-Nogales, Alba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136151/
https://www.ncbi.nlm.nih.gov/pubmed/37107352
http://dx.doi.org/10.3390/antiox12040978
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author Rodríguez-Sojo, María Jesús
Ruiz-Malagón, Antonio Jesús
Hidalgo-García, Laura
Molina-Tijeras, Jose Alberto
Diez-Echave, Patricia
López-Escanez, Laura
Rosati, Lucrezia
González-Lozano, Elena
Cenis-Cifuentes, Laura
García-García, Jorge
García, Federico
Robles-Vera, Iñaki
Romero, Miguel
Duarte, Juan
Cenis, José Luis
Lozano-Pérez, Antonio Abel
Gálvez, Julio
Rodríguez-Cabezas, María Elena
Rodríguez-Nogales, Alba
author_facet Rodríguez-Sojo, María Jesús
Ruiz-Malagón, Antonio Jesús
Hidalgo-García, Laura
Molina-Tijeras, Jose Alberto
Diez-Echave, Patricia
López-Escanez, Laura
Rosati, Lucrezia
González-Lozano, Elena
Cenis-Cifuentes, Laura
García-García, Jorge
García, Federico
Robles-Vera, Iñaki
Romero, Miguel
Duarte, Juan
Cenis, José Luis
Lozano-Pérez, Antonio Abel
Gálvez, Julio
Rodríguez-Cabezas, María Elena
Rodríguez-Nogales, Alba
author_sort Rodríguez-Sojo, María Jesús
collection PubMed
description Obesity is a global health issue, in which modifications in gut microbiota composition have a key role. Different therapeutic strategies are being developed in combination with diet and exercise, including the use of plant extracts, such as those obtained from Morus alba L. leaves. Recent studies have revealed their anti-inflammatory and antioxidant properties. The aim of the present work was to evaluate whether the beneficial effects of M. alba L. leaf extract in high-fat diet-induced obesity in mice is correlated with its impact on gut microbiota. The extract reduced body weight gain and attenuated lipid accumulation, as well as increased glucose sensitivity. These effects were associated with an amelioration of the obesity-associated inflammatory status, most probably due to the described antioxidant properties of the extract. Moreover, M. alba L. leaf extract mitigated gut dysbiosis, which was evidenced by the restoration of the Firmicutes/Bacteroidota ratio and the decrease in plasma lipopolysaccharide (LPS) levels. Specifically, the extract administration reduced Alistipes and increased Faecalibaculum abundance, these effects being correlated with the beneficial effects exerted by the extract on the obesity-associated inflammation. In conclusion, anti-obesogenic effects of M. alba L. leaf extract may be mediated through the amelioration of gut dysbiosis.
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spelling pubmed-101361512023-04-28 The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice Rodríguez-Sojo, María Jesús Ruiz-Malagón, Antonio Jesús Hidalgo-García, Laura Molina-Tijeras, Jose Alberto Diez-Echave, Patricia López-Escanez, Laura Rosati, Lucrezia González-Lozano, Elena Cenis-Cifuentes, Laura García-García, Jorge García, Federico Robles-Vera, Iñaki Romero, Miguel Duarte, Juan Cenis, José Luis Lozano-Pérez, Antonio Abel Gálvez, Julio Rodríguez-Cabezas, María Elena Rodríguez-Nogales, Alba Antioxidants (Basel) Article Obesity is a global health issue, in which modifications in gut microbiota composition have a key role. Different therapeutic strategies are being developed in combination with diet and exercise, including the use of plant extracts, such as those obtained from Morus alba L. leaves. Recent studies have revealed their anti-inflammatory and antioxidant properties. The aim of the present work was to evaluate whether the beneficial effects of M. alba L. leaf extract in high-fat diet-induced obesity in mice is correlated with its impact on gut microbiota. The extract reduced body weight gain and attenuated lipid accumulation, as well as increased glucose sensitivity. These effects were associated with an amelioration of the obesity-associated inflammatory status, most probably due to the described antioxidant properties of the extract. Moreover, M. alba L. leaf extract mitigated gut dysbiosis, which was evidenced by the restoration of the Firmicutes/Bacteroidota ratio and the decrease in plasma lipopolysaccharide (LPS) levels. Specifically, the extract administration reduced Alistipes and increased Faecalibaculum abundance, these effects being correlated with the beneficial effects exerted by the extract on the obesity-associated inflammation. In conclusion, anti-obesogenic effects of M. alba L. leaf extract may be mediated through the amelioration of gut dysbiosis. MDPI 2023-04-21 /pmc/articles/PMC10136151/ /pubmed/37107352 http://dx.doi.org/10.3390/antiox12040978 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rodríguez-Sojo, María Jesús
Ruiz-Malagón, Antonio Jesús
Hidalgo-García, Laura
Molina-Tijeras, Jose Alberto
Diez-Echave, Patricia
López-Escanez, Laura
Rosati, Lucrezia
González-Lozano, Elena
Cenis-Cifuentes, Laura
García-García, Jorge
García, Federico
Robles-Vera, Iñaki
Romero, Miguel
Duarte, Juan
Cenis, José Luis
Lozano-Pérez, Antonio Abel
Gálvez, Julio
Rodríguez-Cabezas, María Elena
Rodríguez-Nogales, Alba
The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice
title The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice
title_full The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice
title_fullStr The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice
title_full_unstemmed The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice
title_short The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice
title_sort prebiotic effects of an extract with antioxidant properties from morus alba l. contribute to ameliorate high-fat diet-induced obesity in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136151/
https://www.ncbi.nlm.nih.gov/pubmed/37107352
http://dx.doi.org/10.3390/antiox12040978
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