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The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice
Obesity is a global health issue, in which modifications in gut microbiota composition have a key role. Different therapeutic strategies are being developed in combination with diet and exercise, including the use of plant extracts, such as those obtained from Morus alba L. leaves. Recent studies ha...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136151/ https://www.ncbi.nlm.nih.gov/pubmed/37107352 http://dx.doi.org/10.3390/antiox12040978 |
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author | Rodríguez-Sojo, María Jesús Ruiz-Malagón, Antonio Jesús Hidalgo-García, Laura Molina-Tijeras, Jose Alberto Diez-Echave, Patricia López-Escanez, Laura Rosati, Lucrezia González-Lozano, Elena Cenis-Cifuentes, Laura García-García, Jorge García, Federico Robles-Vera, Iñaki Romero, Miguel Duarte, Juan Cenis, José Luis Lozano-Pérez, Antonio Abel Gálvez, Julio Rodríguez-Cabezas, María Elena Rodríguez-Nogales, Alba |
author_facet | Rodríguez-Sojo, María Jesús Ruiz-Malagón, Antonio Jesús Hidalgo-García, Laura Molina-Tijeras, Jose Alberto Diez-Echave, Patricia López-Escanez, Laura Rosati, Lucrezia González-Lozano, Elena Cenis-Cifuentes, Laura García-García, Jorge García, Federico Robles-Vera, Iñaki Romero, Miguel Duarte, Juan Cenis, José Luis Lozano-Pérez, Antonio Abel Gálvez, Julio Rodríguez-Cabezas, María Elena Rodríguez-Nogales, Alba |
author_sort | Rodríguez-Sojo, María Jesús |
collection | PubMed |
description | Obesity is a global health issue, in which modifications in gut microbiota composition have a key role. Different therapeutic strategies are being developed in combination with diet and exercise, including the use of plant extracts, such as those obtained from Morus alba L. leaves. Recent studies have revealed their anti-inflammatory and antioxidant properties. The aim of the present work was to evaluate whether the beneficial effects of M. alba L. leaf extract in high-fat diet-induced obesity in mice is correlated with its impact on gut microbiota. The extract reduced body weight gain and attenuated lipid accumulation, as well as increased glucose sensitivity. These effects were associated with an amelioration of the obesity-associated inflammatory status, most probably due to the described antioxidant properties of the extract. Moreover, M. alba L. leaf extract mitigated gut dysbiosis, which was evidenced by the restoration of the Firmicutes/Bacteroidota ratio and the decrease in plasma lipopolysaccharide (LPS) levels. Specifically, the extract administration reduced Alistipes and increased Faecalibaculum abundance, these effects being correlated with the beneficial effects exerted by the extract on the obesity-associated inflammation. In conclusion, anti-obesogenic effects of M. alba L. leaf extract may be mediated through the amelioration of gut dysbiosis. |
format | Online Article Text |
id | pubmed-10136151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101361512023-04-28 The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice Rodríguez-Sojo, María Jesús Ruiz-Malagón, Antonio Jesús Hidalgo-García, Laura Molina-Tijeras, Jose Alberto Diez-Echave, Patricia López-Escanez, Laura Rosati, Lucrezia González-Lozano, Elena Cenis-Cifuentes, Laura García-García, Jorge García, Federico Robles-Vera, Iñaki Romero, Miguel Duarte, Juan Cenis, José Luis Lozano-Pérez, Antonio Abel Gálvez, Julio Rodríguez-Cabezas, María Elena Rodríguez-Nogales, Alba Antioxidants (Basel) Article Obesity is a global health issue, in which modifications in gut microbiota composition have a key role. Different therapeutic strategies are being developed in combination with diet and exercise, including the use of plant extracts, such as those obtained from Morus alba L. leaves. Recent studies have revealed their anti-inflammatory and antioxidant properties. The aim of the present work was to evaluate whether the beneficial effects of M. alba L. leaf extract in high-fat diet-induced obesity in mice is correlated with its impact on gut microbiota. The extract reduced body weight gain and attenuated lipid accumulation, as well as increased glucose sensitivity. These effects were associated with an amelioration of the obesity-associated inflammatory status, most probably due to the described antioxidant properties of the extract. Moreover, M. alba L. leaf extract mitigated gut dysbiosis, which was evidenced by the restoration of the Firmicutes/Bacteroidota ratio and the decrease in plasma lipopolysaccharide (LPS) levels. Specifically, the extract administration reduced Alistipes and increased Faecalibaculum abundance, these effects being correlated with the beneficial effects exerted by the extract on the obesity-associated inflammation. In conclusion, anti-obesogenic effects of M. alba L. leaf extract may be mediated through the amelioration of gut dysbiosis. MDPI 2023-04-21 /pmc/articles/PMC10136151/ /pubmed/37107352 http://dx.doi.org/10.3390/antiox12040978 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rodríguez-Sojo, María Jesús Ruiz-Malagón, Antonio Jesús Hidalgo-García, Laura Molina-Tijeras, Jose Alberto Diez-Echave, Patricia López-Escanez, Laura Rosati, Lucrezia González-Lozano, Elena Cenis-Cifuentes, Laura García-García, Jorge García, Federico Robles-Vera, Iñaki Romero, Miguel Duarte, Juan Cenis, José Luis Lozano-Pérez, Antonio Abel Gálvez, Julio Rodríguez-Cabezas, María Elena Rodríguez-Nogales, Alba The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice |
title | The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice |
title_full | The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice |
title_fullStr | The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice |
title_full_unstemmed | The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice |
title_short | The Prebiotic Effects of an Extract with Antioxidant Properties from Morus alba L. Contribute to Ameliorate High-Fat Diet-Induced Obesity in Mice |
title_sort | prebiotic effects of an extract with antioxidant properties from morus alba l. contribute to ameliorate high-fat diet-induced obesity in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136151/ https://www.ncbi.nlm.nih.gov/pubmed/37107352 http://dx.doi.org/10.3390/antiox12040978 |
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