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TP53 Alterations in Myelodysplastic Syndromes and Acute Myeloid Leukemia

TP53 mutations are less frequent in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) than in solid tumors, except in secondary and therapy-related MDS/AMLs, and in cases with complex monosomal karyotype. As in solid tumors, missense mutations predominate, with the same hotspot mutate...

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Detalles Bibliográficos
Autores principales:	Rahmé, Ramy, Braun, Thorsten, Manfredi, James J., Fenaux, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136154/ https://www.ncbi.nlm.nih.gov/pubmed/37189770 http://dx.doi.org/10.3390/biomedicines11041152

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