Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition

PPARγ represents a key target for the treatment of type 2 diabetes and metabolic syndrome. To avoid serious adverse effects related to the PPARγ agonism profile of traditional antidiabetic drugs, a new opportunity is represented by the development of molecules acting as inhibitors of PPARγ phosphory...

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Detalles Bibliográficos
Autores principales: Capelli, Davide, Cazzaniga, Giulia, Mori, Matteo, Laghezza, Antonio, Loiodice, Fulvio, Quaglia, Martina, Negro, Elisa, Meneghetti, Fiorella, Villa, Stefania, Montanari, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136296/
https://www.ncbi.nlm.nih.gov/pubmed/37189440
http://dx.doi.org/10.3390/biom13040694

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