Inherited Retinal Degeneration: Towards the Development of a Combination Therapy Targeting Histone Deacetylase, Poly (ADP-Ribose) Polymerase, and Calpain

Inherited retinal degeneration (IRD) represents a diverse group of gene mutation-induced blinding diseases. In IRD, the loss of photoreceptors is often connected to excessive activation of histone-deacetylase (HDAC), poly-ADP-ribose-polymerase (PARP), and calpain-type proteases (calpain). Moreover,...

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Detalles Bibliográficos
Autores principales: Dong, Yujie, Yan, Jie, Yang, Ming, Xu, Wenrong, Hu, Zhulin, Paquet-Durand, François, Jiao, Kangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136301/
https://www.ncbi.nlm.nih.gov/pubmed/37189329
http://dx.doi.org/10.3390/biom13040581

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