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State of the Art of Cardiac Amyloidosis
Cardiac amyloidosis is defined by extracellular deposition of misfolded proteins in the heart. The most frequent cases of cardiac amyloidosis are caused by transthyretin and light chain amyloidosis. This condition is underdiagnosed, and its incidence has been continuously rising in recent studies be...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136308/ https://www.ncbi.nlm.nih.gov/pubmed/37189662 http://dx.doi.org/10.3390/biomedicines11041045 |
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author | Belfeki, Nabil Ghriss, Nouha Monchi, Mehran Moini, Cyrus |
author_facet | Belfeki, Nabil Ghriss, Nouha Monchi, Mehran Moini, Cyrus |
author_sort | Belfeki, Nabil |
collection | PubMed |
description | Cardiac amyloidosis is defined by extracellular deposition of misfolded proteins in the heart. The most frequent cases of cardiac amyloidosis are caused by transthyretin and light chain amyloidosis. This condition is underdiagnosed, and its incidence has been continuously rising in recent studies because of the aging of the population and the development of noninvasive multimodal diagnostic tools. Amyloid infiltration affects all cardiac tunics and causes heart failure with preserved ejection fraction, aortic stenosis, arrythmia, and conductive disorder. Innovative, specific therapeutic approaches have demonstrated an improvement in affected organs and the global survival of patients. This condition is no longer considered rare and incurable. Thus, better knowledge of the disease is mandatory. This review will provide a digest of the clinical signs and symptoms of cardiac amyloidosis, the diagnostic tools used to confirm the diagnosis, and current symptomatic and etiopathogenic management considerations according to guidelines and recommendations. |
format | Online Article Text |
id | pubmed-10136308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101363082023-04-28 State of the Art of Cardiac Amyloidosis Belfeki, Nabil Ghriss, Nouha Monchi, Mehran Moini, Cyrus Biomedicines Review Cardiac amyloidosis is defined by extracellular deposition of misfolded proteins in the heart. The most frequent cases of cardiac amyloidosis are caused by transthyretin and light chain amyloidosis. This condition is underdiagnosed, and its incidence has been continuously rising in recent studies because of the aging of the population and the development of noninvasive multimodal diagnostic tools. Amyloid infiltration affects all cardiac tunics and causes heart failure with preserved ejection fraction, aortic stenosis, arrythmia, and conductive disorder. Innovative, specific therapeutic approaches have demonstrated an improvement in affected organs and the global survival of patients. This condition is no longer considered rare and incurable. Thus, better knowledge of the disease is mandatory. This review will provide a digest of the clinical signs and symptoms of cardiac amyloidosis, the diagnostic tools used to confirm the diagnosis, and current symptomatic and etiopathogenic management considerations according to guidelines and recommendations. MDPI 2023-03-28 /pmc/articles/PMC10136308/ /pubmed/37189662 http://dx.doi.org/10.3390/biomedicines11041045 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Belfeki, Nabil Ghriss, Nouha Monchi, Mehran Moini, Cyrus State of the Art of Cardiac Amyloidosis |
title | State of the Art of Cardiac Amyloidosis |
title_full | State of the Art of Cardiac Amyloidosis |
title_fullStr | State of the Art of Cardiac Amyloidosis |
title_full_unstemmed | State of the Art of Cardiac Amyloidosis |
title_short | State of the Art of Cardiac Amyloidosis |
title_sort | state of the art of cardiac amyloidosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136308/ https://www.ncbi.nlm.nih.gov/pubmed/37189662 http://dx.doi.org/10.3390/biomedicines11041045 |
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