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State of the Art of Cardiac Amyloidosis

Cardiac amyloidosis is defined by extracellular deposition of misfolded proteins in the heart. The most frequent cases of cardiac amyloidosis are caused by transthyretin and light chain amyloidosis. This condition is underdiagnosed, and its incidence has been continuously rising in recent studies be...

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Autores principales: Belfeki, Nabil, Ghriss, Nouha, Monchi, Mehran, Moini, Cyrus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136308/
https://www.ncbi.nlm.nih.gov/pubmed/37189662
http://dx.doi.org/10.3390/biomedicines11041045
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author Belfeki, Nabil
Ghriss, Nouha
Monchi, Mehran
Moini, Cyrus
author_facet Belfeki, Nabil
Ghriss, Nouha
Monchi, Mehran
Moini, Cyrus
author_sort Belfeki, Nabil
collection PubMed
description Cardiac amyloidosis is defined by extracellular deposition of misfolded proteins in the heart. The most frequent cases of cardiac amyloidosis are caused by transthyretin and light chain amyloidosis. This condition is underdiagnosed, and its incidence has been continuously rising in recent studies because of the aging of the population and the development of noninvasive multimodal diagnostic tools. Amyloid infiltration affects all cardiac tunics and causes heart failure with preserved ejection fraction, aortic stenosis, arrythmia, and conductive disorder. Innovative, specific therapeutic approaches have demonstrated an improvement in affected organs and the global survival of patients. This condition is no longer considered rare and incurable. Thus, better knowledge of the disease is mandatory. This review will provide a digest of the clinical signs and symptoms of cardiac amyloidosis, the diagnostic tools used to confirm the diagnosis, and current symptomatic and etiopathogenic management considerations according to guidelines and recommendations.
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spelling pubmed-101363082023-04-28 State of the Art of Cardiac Amyloidosis Belfeki, Nabil Ghriss, Nouha Monchi, Mehran Moini, Cyrus Biomedicines Review Cardiac amyloidosis is defined by extracellular deposition of misfolded proteins in the heart. The most frequent cases of cardiac amyloidosis are caused by transthyretin and light chain amyloidosis. This condition is underdiagnosed, and its incidence has been continuously rising in recent studies because of the aging of the population and the development of noninvasive multimodal diagnostic tools. Amyloid infiltration affects all cardiac tunics and causes heart failure with preserved ejection fraction, aortic stenosis, arrythmia, and conductive disorder. Innovative, specific therapeutic approaches have demonstrated an improvement in affected organs and the global survival of patients. This condition is no longer considered rare and incurable. Thus, better knowledge of the disease is mandatory. This review will provide a digest of the clinical signs and symptoms of cardiac amyloidosis, the diagnostic tools used to confirm the diagnosis, and current symptomatic and etiopathogenic management considerations according to guidelines and recommendations. MDPI 2023-03-28 /pmc/articles/PMC10136308/ /pubmed/37189662 http://dx.doi.org/10.3390/biomedicines11041045 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Belfeki, Nabil
Ghriss, Nouha
Monchi, Mehran
Moini, Cyrus
State of the Art of Cardiac Amyloidosis
title State of the Art of Cardiac Amyloidosis
title_full State of the Art of Cardiac Amyloidosis
title_fullStr State of the Art of Cardiac Amyloidosis
title_full_unstemmed State of the Art of Cardiac Amyloidosis
title_short State of the Art of Cardiac Amyloidosis
title_sort state of the art of cardiac amyloidosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136308/
https://www.ncbi.nlm.nih.gov/pubmed/37189662
http://dx.doi.org/10.3390/biomedicines11041045
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