Cargando…

Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis

Evident similarities in pathological features in aging and Alzheimer’s disease (AD) raise the question of a role for natural age-related adaptive mechanisms in the prevention/elimination of disturbances in interrelations between different brain areas. In our previous electroencephalogram (EEG) studi...

Descripción completa

Detalles Bibliográficos
Autores principales: Vorobyov, Vasily, Deev, Alexander, Chaprov, Kirill, Ustyugov, Aleksey A., Lysikova, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136324/
https://www.ncbi.nlm.nih.gov/pubmed/37189768
http://dx.doi.org/10.3390/biomedicines11041151
_version_ 1785032190776573952
author Vorobyov, Vasily
Deev, Alexander
Chaprov, Kirill
Ustyugov, Aleksey A.
Lysikova, Ekaterina
author_facet Vorobyov, Vasily
Deev, Alexander
Chaprov, Kirill
Ustyugov, Aleksey A.
Lysikova, Ekaterina
author_sort Vorobyov, Vasily
collection PubMed
description Evident similarities in pathological features in aging and Alzheimer’s disease (AD) raise the question of a role for natural age-related adaptive mechanisms in the prevention/elimination of disturbances in interrelations between different brain areas. In our previous electroencephalogram (EEG) studies on 5xFAD- and FUS-transgenic mice, as models of AD and amyotrophic lateral sclerosis (ALS), this suggestion was indirectly confirmed. In the current study, age-related changes in direct EEG synchrony/coherence between the brain structures were evaluated. Methods: In 5xFAD mice of 6-, 9-, 12-, and 18-month ages and their wild-type (WT(5xFAD)) littermates, we analyzed baseline EEG coherence between the cortex, hippocampus/putamen, ventral tegmental area, and substantia nigra. Additionally, EEG coherence between the cortex and putamen was analyzed in 2- and 5-month-old FUS mice. Results: In the 5xFAD mice, suppressed levels of inter-structural coherence vs. those in WT(5xFAD) littermates were observed at ages of 6, 9, and 12 months. In 18-month-old 5xFAD mice, only the hippocampus ventral tegmental area coherence was significantly reduced. In 2-month-old FUS vs. WT(FUS) mice, the cortex–putamen coherence suppression, dominated in the right hemisphere, was observed. In 5-month-old mice, EEG coherence was maximal in both groups. Conclusion: Neurodegenerative pathologies are accompanied by the significant attenuation of intracerebral EEG coherence. Our data are supportive for the involvement of age-related adaptive mechanisms in intracerebral disturbances produced by neurodegeneration.
format Online
Article
Text
id pubmed-10136324
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101363242023-04-28 Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis Vorobyov, Vasily Deev, Alexander Chaprov, Kirill Ustyugov, Aleksey A. Lysikova, Ekaterina Biomedicines Article Evident similarities in pathological features in aging and Alzheimer’s disease (AD) raise the question of a role for natural age-related adaptive mechanisms in the prevention/elimination of disturbances in interrelations between different brain areas. In our previous electroencephalogram (EEG) studies on 5xFAD- and FUS-transgenic mice, as models of AD and amyotrophic lateral sclerosis (ALS), this suggestion was indirectly confirmed. In the current study, age-related changes in direct EEG synchrony/coherence between the brain structures were evaluated. Methods: In 5xFAD mice of 6-, 9-, 12-, and 18-month ages and their wild-type (WT(5xFAD)) littermates, we analyzed baseline EEG coherence between the cortex, hippocampus/putamen, ventral tegmental area, and substantia nigra. Additionally, EEG coherence between the cortex and putamen was analyzed in 2- and 5-month-old FUS mice. Results: In the 5xFAD mice, suppressed levels of inter-structural coherence vs. those in WT(5xFAD) littermates were observed at ages of 6, 9, and 12 months. In 18-month-old 5xFAD mice, only the hippocampus ventral tegmental area coherence was significantly reduced. In 2-month-old FUS vs. WT(FUS) mice, the cortex–putamen coherence suppression, dominated in the right hemisphere, was observed. In 5-month-old mice, EEG coherence was maximal in both groups. Conclusion: Neurodegenerative pathologies are accompanied by the significant attenuation of intracerebral EEG coherence. Our data are supportive for the involvement of age-related adaptive mechanisms in intracerebral disturbances produced by neurodegeneration. MDPI 2023-04-11 /pmc/articles/PMC10136324/ /pubmed/37189768 http://dx.doi.org/10.3390/biomedicines11041151 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vorobyov, Vasily
Deev, Alexander
Chaprov, Kirill
Ustyugov, Aleksey A.
Lysikova, Ekaterina
Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis
title Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis
title_full Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis
title_fullStr Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis
title_full_unstemmed Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis
title_short Age-Related Modifications of Electroencephalogram Coherence in Mice Models of Alzheimer’s Disease and Amyotrophic Lateral Sclerosis
title_sort age-related modifications of electroencephalogram coherence in mice models of alzheimer’s disease and amyotrophic lateral sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136324/
https://www.ncbi.nlm.nih.gov/pubmed/37189768
http://dx.doi.org/10.3390/biomedicines11041151
work_keys_str_mv AT vorobyovvasily agerelatedmodificationsofelectroencephalogramcoherenceinmicemodelsofalzheimersdiseaseandamyotrophiclateralsclerosis
AT deevalexander agerelatedmodificationsofelectroencephalogramcoherenceinmicemodelsofalzheimersdiseaseandamyotrophiclateralsclerosis
AT chaprovkirill agerelatedmodificationsofelectroencephalogramcoherenceinmicemodelsofalzheimersdiseaseandamyotrophiclateralsclerosis
AT ustyugovalekseya agerelatedmodificationsofelectroencephalogramcoherenceinmicemodelsofalzheimersdiseaseandamyotrophiclateralsclerosis
AT lysikovaekaterina agerelatedmodificationsofelectroencephalogramcoherenceinmicemodelsofalzheimersdiseaseandamyotrophiclateralsclerosis