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Urticaria: A Narrative Overview of Differential Diagnosis
Urticaria is an inflammatory skin disorder that may occur in isolation or associated with angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth, erythematous or blanching, itchy swelling, called wheals or hives, which greatly vary in size and shape and last less th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136346/ https://www.ncbi.nlm.nih.gov/pubmed/37189714 http://dx.doi.org/10.3390/biomedicines11041096 |
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author | Schettini, Natale Corazza, Monica Schenetti, Cecilia Pacetti, Lucrezia Borghi, Alessandro |
author_facet | Schettini, Natale Corazza, Monica Schenetti, Cecilia Pacetti, Lucrezia Borghi, Alessandro |
author_sort | Schettini, Natale |
collection | PubMed |
description | Urticaria is an inflammatory skin disorder that may occur in isolation or associated with angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth, erythematous or blanching, itchy swelling, called wheals or hives, which greatly vary in size and shape and last less than 24 h before fading to leave normal skin. Urticaria is the consequence of mast-cell degranulation that can be caused by immunological or non-immunological mechanisms. From a clinical point of view, many skin conditions can mimic urticaria and their recognition is mandatory for a correct management and therapeutic approach. We have reviewed all of the main relevant studies which addressed differential diagnosis of urticarial, published until December 2022. The National Library of Medicine PubMed database was used for the electronic research. The present review offers a clinical narrative overview, based on the available literature, of the principal skin disorders that can be misdiagnosed as urticaria (mainly autoinflammatory or autoimmune disorders, drug-induced reactions, and hyperproliferative diseases). The aim of this review is to provide clinicians a useful tool for correctly suspecting and identifying all of these conditions. |
format | Online Article Text |
id | pubmed-10136346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101363462023-04-28 Urticaria: A Narrative Overview of Differential Diagnosis Schettini, Natale Corazza, Monica Schenetti, Cecilia Pacetti, Lucrezia Borghi, Alessandro Biomedicines Review Urticaria is an inflammatory skin disorder that may occur in isolation or associated with angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth, erythematous or blanching, itchy swelling, called wheals or hives, which greatly vary in size and shape and last less than 24 h before fading to leave normal skin. Urticaria is the consequence of mast-cell degranulation that can be caused by immunological or non-immunological mechanisms. From a clinical point of view, many skin conditions can mimic urticaria and their recognition is mandatory for a correct management and therapeutic approach. We have reviewed all of the main relevant studies which addressed differential diagnosis of urticarial, published until December 2022. The National Library of Medicine PubMed database was used for the electronic research. The present review offers a clinical narrative overview, based on the available literature, of the principal skin disorders that can be misdiagnosed as urticaria (mainly autoinflammatory or autoimmune disorders, drug-induced reactions, and hyperproliferative diseases). The aim of this review is to provide clinicians a useful tool for correctly suspecting and identifying all of these conditions. MDPI 2023-04-04 /pmc/articles/PMC10136346/ /pubmed/37189714 http://dx.doi.org/10.3390/biomedicines11041096 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Schettini, Natale Corazza, Monica Schenetti, Cecilia Pacetti, Lucrezia Borghi, Alessandro Urticaria: A Narrative Overview of Differential Diagnosis |
title | Urticaria: A Narrative Overview of Differential Diagnosis |
title_full | Urticaria: A Narrative Overview of Differential Diagnosis |
title_fullStr | Urticaria: A Narrative Overview of Differential Diagnosis |
title_full_unstemmed | Urticaria: A Narrative Overview of Differential Diagnosis |
title_short | Urticaria: A Narrative Overview of Differential Diagnosis |
title_sort | urticaria: a narrative overview of differential diagnosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136346/ https://www.ncbi.nlm.nih.gov/pubmed/37189714 http://dx.doi.org/10.3390/biomedicines11041096 |
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