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Urticaria: A Narrative Overview of Differential Diagnosis

Urticaria is an inflammatory skin disorder that may occur in isolation or associated with angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth, erythematous or blanching, itchy swelling, called wheals or hives, which greatly vary in size and shape and last less th...

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Autores principales: Schettini, Natale, Corazza, Monica, Schenetti, Cecilia, Pacetti, Lucrezia, Borghi, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136346/
https://www.ncbi.nlm.nih.gov/pubmed/37189714
http://dx.doi.org/10.3390/biomedicines11041096
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author Schettini, Natale
Corazza, Monica
Schenetti, Cecilia
Pacetti, Lucrezia
Borghi, Alessandro
author_facet Schettini, Natale
Corazza, Monica
Schenetti, Cecilia
Pacetti, Lucrezia
Borghi, Alessandro
author_sort Schettini, Natale
collection PubMed
description Urticaria is an inflammatory skin disorder that may occur in isolation or associated with angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth, erythematous or blanching, itchy swelling, called wheals or hives, which greatly vary in size and shape and last less than 24 h before fading to leave normal skin. Urticaria is the consequence of mast-cell degranulation that can be caused by immunological or non-immunological mechanisms. From a clinical point of view, many skin conditions can mimic urticaria and their recognition is mandatory for a correct management and therapeutic approach. We have reviewed all of the main relevant studies which addressed differential diagnosis of urticarial, published until December 2022. The National Library of Medicine PubMed database was used for the electronic research. The present review offers a clinical narrative overview, based on the available literature, of the principal skin disorders that can be misdiagnosed as urticaria (mainly autoinflammatory or autoimmune disorders, drug-induced reactions, and hyperproliferative diseases). The aim of this review is to provide clinicians a useful tool for correctly suspecting and identifying all of these conditions.
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spelling pubmed-101363462023-04-28 Urticaria: A Narrative Overview of Differential Diagnosis Schettini, Natale Corazza, Monica Schenetti, Cecilia Pacetti, Lucrezia Borghi, Alessandro Biomedicines Review Urticaria is an inflammatory skin disorder that may occur in isolation or associated with angioedema and/or anaphylaxis. Clinically, it is characterized by the presence of smooth, erythematous or blanching, itchy swelling, called wheals or hives, which greatly vary in size and shape and last less than 24 h before fading to leave normal skin. Urticaria is the consequence of mast-cell degranulation that can be caused by immunological or non-immunological mechanisms. From a clinical point of view, many skin conditions can mimic urticaria and their recognition is mandatory for a correct management and therapeutic approach. We have reviewed all of the main relevant studies which addressed differential diagnosis of urticarial, published until December 2022. The National Library of Medicine PubMed database was used for the electronic research. The present review offers a clinical narrative overview, based on the available literature, of the principal skin disorders that can be misdiagnosed as urticaria (mainly autoinflammatory or autoimmune disorders, drug-induced reactions, and hyperproliferative diseases). The aim of this review is to provide clinicians a useful tool for correctly suspecting and identifying all of these conditions. MDPI 2023-04-04 /pmc/articles/PMC10136346/ /pubmed/37189714 http://dx.doi.org/10.3390/biomedicines11041096 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schettini, Natale
Corazza, Monica
Schenetti, Cecilia
Pacetti, Lucrezia
Borghi, Alessandro
Urticaria: A Narrative Overview of Differential Diagnosis
title Urticaria: A Narrative Overview of Differential Diagnosis
title_full Urticaria: A Narrative Overview of Differential Diagnosis
title_fullStr Urticaria: A Narrative Overview of Differential Diagnosis
title_full_unstemmed Urticaria: A Narrative Overview of Differential Diagnosis
title_short Urticaria: A Narrative Overview of Differential Diagnosis
title_sort urticaria: a narrative overview of differential diagnosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136346/
https://www.ncbi.nlm.nih.gov/pubmed/37189714
http://dx.doi.org/10.3390/biomedicines11041096
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