Cargando…

Whole-Transcriptome Analysis of Repeated Low-Level Sarin-Exposed Rat Hippocampus and Identification of Cerna Networks to Investigate the Mechanism of Sarin-Induced Cognitive Impairment

SIMPLE SUMMARY: Sarin is a potent organophosphate nerve agent that is a representative of a chemical weapon and poses a threat to human health. In this study, the effects of repeated low-level sarin exposure on the cognitive behavior of rats were studied, and the activity of AChE activity and dendri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Jingjing, Liu, Dongxin, Jin, Qian, Chen, Xuejun, Zhang, Ruihua, Shi, Tong, Zhu, Siqing, Zhang, Yi, Zong, Xingxing, Wang, Chen, Li, Liqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136365/ https://www.ncbi.nlm.nih.gov/pubmed/37106826 http://dx.doi.org/10.3390/biology12040627

Ejemplares similares

Sarin: a never-ending story
por: Bolt, Hermann M.
Publicado: (2022)

Effects of sarin on the nervous system in rescue team staff members and police officers 3 years after the Tokyo subway sarin attack.
por: Nishiwaki, Y, et al.
Publicado: (2001)

The Tokyo Attacks in Retrospect Sarin Leads to Memory Loss
por: Hood, E
Publicado: (2001)

Social media video analysis methodology for sarin exposure
por: Toprak, Sadik, et al.
Publicado: (2020)

A Chromogenic Probe for the Selective Recognition of Sarin and Soman Mimic DFP**
por: El Sayed, Sameh, et al.
Publicado: (2014)

Toxic chemical weapons of assassination and warfare: nerve agents VX and sarin
por: Chai, Peter R., et al.
Publicado: (2017)

Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network
por: John, Harald, et al.
Publicado: (2017)

Acute Health Effects and Outcome Following Sarin Gas Attacks in Khan Shaykhun, Syria
por: Alsaleh, Osama I, et al.
Publicado: (2022)

Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice
por: Wei, Zhao, et al.
Publicado: (2022)

Neurosteroid and benzodiazepine combination therapy reduces status epilepticus and long‐term effects of whole‐body sarin exposure in rats
por: Lumley, Lucille, et al.
Publicado: (2019)

Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures
por: Spradling, Kimberly D, et al.
Publicado: (2011)

The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats
por: Caisberger, Filip, et al.
Publicado: (2018)

The Application of Microfibrous Entrapped Activated Carbon Composite Material for the Sarin Simulant Dimethyl Methylphosphonate Adsorption
por: Xie, Yucong, et al.
Publicado: (2023)

Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice
por: Zhu, Siqing, et al.
Publicado: (2023)

Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin
por: Spradling, Kimberly D, et al.
Publicado: (2011)

Epigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness
por: Ashbrook, David G., et al.
Publicado: (2018)

Structure of HI-6•Sarin-Acetylcholinesterase Determined by X-Ray Crystallography and Molecular Dynamics Simulation: Reactivator Mechanism and Design
por: Ekström, Fredrik, et al.
Publicado: (2009)

Hydrolysis of DFP and the Nerve Agent (S)-Sarin by DFPase Proceeds along Two Different Reaction Pathways: Implications for Engineering Bioscavengers
por: Wymore, Troy, et al.
Publicado: (2014)

Toward Efficient Toxic-Gas Detectors: Exploring Molecular Interactions of Sarin and Dimethyl Methylphosphonate with Metal-Centered Phthalocyanine Structures
por: Aldahhak, Hazem, et al.
Publicado: (2020)

Biological Distribution and Metabolic Profiles of Carbon-11 and Fluorine-18 Tracers of VX- and Sarin-Analogs in Sprague–Dawley Rats
por: Hayes, Thomas R., et al.
Publicado: (2020)

p-Hexafluoroisopropanol phenyl functionalized graphene for QCM based detection of dimethyl methylphosphonate, a simulant of the nerve agent sarin
por: Shaik, Mahabul, et al.
Publicado: (2018)

Long-Term Anxiety-like Behavior and Microbiota Changes Induced in Mice by Sublethal Doses of Acute Sarin Surrogate Exposure
por: François, Sabine, et al.
Publicado: (2022)

Molecular Modeling Study of Uncharged Oximes Compared to HI-6 and 2-PAM Inside Human AChE Sarin and VX Conjugates
por: Souza, Felipe Rodrigues de, et al.
Publicado: (2020)

The Tokyo subway sarin attack has long-term effects on survivors: A 10-year study started 5 years after the terrorist incident
por: Sugiyama, Aya, et al.
Publicado: (2020)

Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al
por: He, Chanting, et al.
Publicado: (2021)

Toxic effects and bioaccumulation of pinacolyl methylphosphonate acid in zebrafish following soman exposure to a water environment
por: Zong, Xing-Xing, et al.
Publicado: (2023)

Whole-transcriptome sequencing and ceRNA interaction network of temporomandibular joint osteoarthritis
por: Wu, Fan, et al.
Publicado: (2022)

Transcriptomic Profiling of Tetrodotoxin-Induced Neurotoxicity in Human Cerebral Organoids
por: Liu, Zhanbiao, et al.
Publicado: (2023)

Integrative Analysis Extracts a Core ceRNA Network of the Fetal Hippocampus With Down Syndrome
por: Wang, Shengran, et al.
Publicado: (2020)

Whole-Transcriptome Analysis of LncRNAs Mediated ceRNA Regulation in Granulosa Cells Isolated From Healthy and Atresia Follicles of Chinese Buffalo
por: Pan, Yu, et al.
Publicado: (2021)

Whole-transcriptome analysis and construction of an anther development-related ceRNA network in Chinese cabbage (Brassica campestris L. ssp. pekinensis)
por: Shi, Fengyan, et al.
Publicado: (2022)

MALAT1 Regulated mTOR-Mediated Tau Hyperphosphorylation by Acting as a ceRNA of miR144 in Hippocampus Cells Exposed to High Glucose
por: Lu, Chong, et al.
Publicado: (2021)

Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis
por: Okamoto, Oswaldo K, et al.
Publicado: (2010)

Whole-transcriptome sequencing reveals a vernalization-related ceRNA regulatory network in chinese cabbage (Brassica campestris L. ssp. pekinensis)
por: Shi, Fengyan, et al.
Publicado: (2021)

The whole-transcriptome landscape of muscle and adipose tissues reveals the ceRNA regulation network related to intramuscular fat deposition in yak
por: Wang, Hui, et al.
Publicado: (2020)

Transcriptome Analysis in Hippocampus of Rats Prenatally Exposed to Valproic Acid and Effects of Intranasal Treatment of Oxytocin
por: Matsuo, Kazuya, et al.
Publicado: (2022)

Whole transcriptome analysis and construction of a ceRNA regulatory network related to leaf and petiole development in Chinese cabbage (Brassica campestris L. ssp. pekinensis)
por: Shi, Fengyan, et al.
Publicado: (2023)

Whole-transcriptome sequencing identifies key differentially expressed circRNAs/lncRNAs/miRNAs/mRNAs and linked ceRNA networks in adult degenerative scoliosis
por: Shi, Xin, et al.
Publicado: (2023)

Memory Modulation Factors in Hippocampus Exposed to Radiation
por: Krotkova, O.A., et al.
Publicado: (2021)

Phosphoproteomic profiling of the hippocampus of offspring rats exposed to prenatal stress
por: Li, Qinghong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_iij9kqaqgsc409k0p9021qjc7b