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miRNAs as Predictors of Barrier Integrity
The human body has several barriers that protect its integrity and shield it from mechanical, chemical, and microbial harm. The various barriers include the skin, intestinal and respiratory epithelia, blood–brain barrier (BBB), and immune system. In the present review, the focus is on the physical b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136429/ https://www.ncbi.nlm.nih.gov/pubmed/37185497 http://dx.doi.org/10.3390/bios13040422 |
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author | Bovari-Biri, Judit Garai, Kitti Banfai, Krisztina Csongei, Veronika Pongracz, Judit E. |
author_facet | Bovari-Biri, Judit Garai, Kitti Banfai, Krisztina Csongei, Veronika Pongracz, Judit E. |
author_sort | Bovari-Biri, Judit |
collection | PubMed |
description | The human body has several barriers that protect its integrity and shield it from mechanical, chemical, and microbial harm. The various barriers include the skin, intestinal and respiratory epithelia, blood–brain barrier (BBB), and immune system. In the present review, the focus is on the physical barriers that are formed by cell layers. The barrier function is influenced by the molecular microenvironment of the cells forming the barriers. The integrity of the barrier cell layers is maintained by the intricate balance of protein expression that is partly regulated by microRNAs (miRNAs) both in the intracellular space and the extracellular microenvironment. The detection of changes in miRNA patterns has become a major focus of diagnostic, prognostic, and disease progression, as well as therapy-response, markers using a great variety of detection systems in recent years. In the present review, we highlight the importance of liquid biopsies in assessing barrier integrity and challenges in differential miRNA detection. |
format | Online Article Text |
id | pubmed-10136429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101364292023-04-28 miRNAs as Predictors of Barrier Integrity Bovari-Biri, Judit Garai, Kitti Banfai, Krisztina Csongei, Veronika Pongracz, Judit E. Biosensors (Basel) Review The human body has several barriers that protect its integrity and shield it from mechanical, chemical, and microbial harm. The various barriers include the skin, intestinal and respiratory epithelia, blood–brain barrier (BBB), and immune system. In the present review, the focus is on the physical barriers that are formed by cell layers. The barrier function is influenced by the molecular microenvironment of the cells forming the barriers. The integrity of the barrier cell layers is maintained by the intricate balance of protein expression that is partly regulated by microRNAs (miRNAs) both in the intracellular space and the extracellular microenvironment. The detection of changes in miRNA patterns has become a major focus of diagnostic, prognostic, and disease progression, as well as therapy-response, markers using a great variety of detection systems in recent years. In the present review, we highlight the importance of liquid biopsies in assessing barrier integrity and challenges in differential miRNA detection. MDPI 2023-03-26 /pmc/articles/PMC10136429/ /pubmed/37185497 http://dx.doi.org/10.3390/bios13040422 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bovari-Biri, Judit Garai, Kitti Banfai, Krisztina Csongei, Veronika Pongracz, Judit E. miRNAs as Predictors of Barrier Integrity |
title | miRNAs as Predictors of Barrier Integrity |
title_full | miRNAs as Predictors of Barrier Integrity |
title_fullStr | miRNAs as Predictors of Barrier Integrity |
title_full_unstemmed | miRNAs as Predictors of Barrier Integrity |
title_short | miRNAs as Predictors of Barrier Integrity |
title_sort | mirnas as predictors of barrier integrity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136429/ https://www.ncbi.nlm.nih.gov/pubmed/37185497 http://dx.doi.org/10.3390/bios13040422 |
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