Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review

Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role in cancerogenesis, metastasis and neoangiogen...

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Autores principales: Kalita, Agnieszka, Sikora-Skrabaka, Magdalena, Nowakowska-Zajdel, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136553/
https://www.ncbi.nlm.nih.gov/pubmed/37185715
http://dx.doi.org/10.3390/cimb45040191
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author Kalita, Agnieszka
Sikora-Skrabaka, Magdalena
Nowakowska-Zajdel, Ewa
author_facet Kalita, Agnieszka
Sikora-Skrabaka, Magdalena
Nowakowska-Zajdel, Ewa
author_sort Kalita, Agnieszka
collection PubMed
description Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role in cancerogenesis, metastasis and neoangiogenesis. MicroRNAs are small single-stranded non-coding RNAs that take part in the post-transcriptional regulation of gene expression. Some ADAM proteins can be targets for microRNAs. In this review, we analyze the impact of microRNA/ADAM protein axes in GI cancers.
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spelling pubmed-101365532023-04-28 Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review Kalita, Agnieszka Sikora-Skrabaka, Magdalena Nowakowska-Zajdel, Ewa Curr Issues Mol Biol Review Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role in cancerogenesis, metastasis and neoangiogenesis. MicroRNAs are small single-stranded non-coding RNAs that take part in the post-transcriptional regulation of gene expression. Some ADAM proteins can be targets for microRNAs. In this review, we analyze the impact of microRNA/ADAM protein axes in GI cancers. MDPI 2023-04-03 /pmc/articles/PMC10136553/ /pubmed/37185715 http://dx.doi.org/10.3390/cimb45040191 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kalita, Agnieszka
Sikora-Skrabaka, Magdalena
Nowakowska-Zajdel, Ewa
Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review
title Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review
title_full Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review
title_fullStr Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review
title_full_unstemmed Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review
title_short Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review
title_sort role of some microrna/adam proteins axes in gastrointestinal cancers as a novel biomarkers and potential therapeutic targets—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136553/
https://www.ncbi.nlm.nih.gov/pubmed/37185715
http://dx.doi.org/10.3390/cimb45040191
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