USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons

Stress-induced mitophagy, a tightly regulated process that targets dysfunctional mitochondria for autophagy-dependent degradation, mainly relies on two proteins, PINK1 and Parkin, which genes are mutated in some forms of familiar Parkinson’s Disease (PD). Upon mitochondrial damage, the protein kinas...

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Detalles Bibliográficos
Autores principales: Mauri, Sofia, Bernardo, Greta, Martinez, Aitor, Favaro, Mariavittoria, Trevisan, Marta, Cobraiville, Gael, Fillet, Marianne, Caicci, Federico, Whitworth, Alexander J., Ziviani, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136645/
https://www.ncbi.nlm.nih.gov/pubmed/37190052
http://dx.doi.org/10.3390/cells12081143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136645/
https://www.ncbi.nlm.nih.gov/pubmed/37190052
http://dx.doi.org/10.3390/cells12081143

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