Improving the Efficiency of Electrocatalysis of Cytochrome P450 3A4 by Modifying the Electrode with Membrane Protein Streptolysin O for Studying the Metabolic Transformations of Drugs

In the present work, screen-printed electrodes (SPE) modified with a synthetic surfactant, didodecyldimethylammonium bromide (DDAB) and streptolysin O (SLO) were prepared for cytochrome P450 3A4 (CYP3A4) immobilization, direct non-catalytic and catalytic electrochemistry. The immobilized CYP3A4 demo...

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Detalles Bibliográficos
Autores principales: Koroleva, Polina I., Gilep, Andrei A., Kraevsky, Sergey V., Tsybruk, Tatiana V., Shumyantseva, Victoria V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136652/
https://www.ncbi.nlm.nih.gov/pubmed/37185532
http://dx.doi.org/10.3390/bios13040457

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