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Transfer learning-assisted 3D deep learning models for knee osteoarthritis detection: Data from the osteoarthritis initiative

Knee osteoarthritis is one of the most common musculoskeletal diseases and is usually diagnosed with medical imaging techniques. Conventionally, case identification using plain radiography is practiced. However, we acknowledge that knee osteoarthritis is a 3D complexity; hence, magnetic resonance im...

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Autores principales: Yeoh, Pauline Shan Qing, Lai, Khin Wee, Goh, Siew Li, Hasikin, Khairunnisa, Wu, Xiang, Li, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136763/
https://www.ncbi.nlm.nih.gov/pubmed/37122858
http://dx.doi.org/10.3389/fbioe.2023.1164655
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author Yeoh, Pauline Shan Qing
Lai, Khin Wee
Goh, Siew Li
Hasikin, Khairunnisa
Wu, Xiang
Li, Pei
author_facet Yeoh, Pauline Shan Qing
Lai, Khin Wee
Goh, Siew Li
Hasikin, Khairunnisa
Wu, Xiang
Li, Pei
author_sort Yeoh, Pauline Shan Qing
collection PubMed
description Knee osteoarthritis is one of the most common musculoskeletal diseases and is usually diagnosed with medical imaging techniques. Conventionally, case identification using plain radiography is practiced. However, we acknowledge that knee osteoarthritis is a 3D complexity; hence, magnetic resonance imaging will be the ideal modality to reveal the hidden osteoarthritis features from a three-dimensional view. In this work, the feasibility of well-known convolutional neural network (CNN) structures (ResNet, DenseNet, VGG, and AlexNet) to distinguish knees with and without osteoarthritis (OA) is investigated. Using 3D convolutional layers, we demonstrated the potential of 3D convolutional neural networks of 13 different architectures in knee osteoarthritis diagnosis. We used transfer learning by transforming 2D pre-trained weights into 3D as initial weights for the training of the 3D models. The performance of the models was compared and evaluated based on the performance metrics [balanced accuracy, precision, F1 score, and area under receiver operating characteristic (AUC) curve]. This study suggested that transfer learning indeed enhanced the performance of the models, especially for ResNet and DenseNet models. Transfer learning-based models presented promising results, with ResNet34 achieving the best overall accuracy of 0.875 and an F1 score of 0.871. The results also showed that shallow networks yielded better performance than deeper neural networks, demonstrated by ResNet18, DenseNet121, and VGG11 with AUC values of 0.945, 0.914, and 0.928, respectively. This encourages the application of clinical diagnostic aid for knee osteoarthritis using 3DCNN even in limited hardware conditions.
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spelling pubmed-101367632023-04-28 Transfer learning-assisted 3D deep learning models for knee osteoarthritis detection: Data from the osteoarthritis initiative Yeoh, Pauline Shan Qing Lai, Khin Wee Goh, Siew Li Hasikin, Khairunnisa Wu, Xiang Li, Pei Front Bioeng Biotechnol Bioengineering and Biotechnology Knee osteoarthritis is one of the most common musculoskeletal diseases and is usually diagnosed with medical imaging techniques. Conventionally, case identification using plain radiography is practiced. However, we acknowledge that knee osteoarthritis is a 3D complexity; hence, magnetic resonance imaging will be the ideal modality to reveal the hidden osteoarthritis features from a three-dimensional view. In this work, the feasibility of well-known convolutional neural network (CNN) structures (ResNet, DenseNet, VGG, and AlexNet) to distinguish knees with and without osteoarthritis (OA) is investigated. Using 3D convolutional layers, we demonstrated the potential of 3D convolutional neural networks of 13 different architectures in knee osteoarthritis diagnosis. We used transfer learning by transforming 2D pre-trained weights into 3D as initial weights for the training of the 3D models. The performance of the models was compared and evaluated based on the performance metrics [balanced accuracy, precision, F1 score, and area under receiver operating characteristic (AUC) curve]. This study suggested that transfer learning indeed enhanced the performance of the models, especially for ResNet and DenseNet models. Transfer learning-based models presented promising results, with ResNet34 achieving the best overall accuracy of 0.875 and an F1 score of 0.871. The results also showed that shallow networks yielded better performance than deeper neural networks, demonstrated by ResNet18, DenseNet121, and VGG11 with AUC values of 0.945, 0.914, and 0.928, respectively. This encourages the application of clinical diagnostic aid for knee osteoarthritis using 3DCNN even in limited hardware conditions. Frontiers Media S.A. 2023-04-13 /pmc/articles/PMC10136763/ /pubmed/37122858 http://dx.doi.org/10.3389/fbioe.2023.1164655 Text en Copyright © 2023 Yeoh, Lai, Goh, Hasikin, Wu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Yeoh, Pauline Shan Qing
Lai, Khin Wee
Goh, Siew Li
Hasikin, Khairunnisa
Wu, Xiang
Li, Pei
Transfer learning-assisted 3D deep learning models for knee osteoarthritis detection: Data from the osteoarthritis initiative
title Transfer learning-assisted 3D deep learning models for knee osteoarthritis detection: Data from the osteoarthritis initiative
title_full Transfer learning-assisted 3D deep learning models for knee osteoarthritis detection: Data from the osteoarthritis initiative
title_fullStr Transfer learning-assisted 3D deep learning models for knee osteoarthritis detection: Data from the osteoarthritis initiative
title_full_unstemmed Transfer learning-assisted 3D deep learning models for knee osteoarthritis detection: Data from the osteoarthritis initiative
title_short Transfer learning-assisted 3D deep learning models for knee osteoarthritis detection: Data from the osteoarthritis initiative
title_sort transfer learning-assisted 3d deep learning models for knee osteoarthritis detection: data from the osteoarthritis initiative
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136763/
https://www.ncbi.nlm.nih.gov/pubmed/37122858
http://dx.doi.org/10.3389/fbioe.2023.1164655
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