The RUNX Family of Proteins, DNA Repair, and Cancer

The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer. Emerging evidence suggests that the dysregulation of RUNX genes can promote genomic instability in both leukemia and sol...

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Detalles Bibliográficos
Autor principal: Krishnan, Vaidehi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136874/
https://www.ncbi.nlm.nih.gov/pubmed/37190015
http://dx.doi.org/10.3390/cells12081106
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author Krishnan, Vaidehi
author_facet Krishnan, Vaidehi
author_sort Krishnan, Vaidehi
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description The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer. Emerging evidence suggests that the dysregulation of RUNX genes can promote genomic instability in both leukemia and solid cancers by impairing DNA repair mechanisms. RUNX proteins control the cellular response to DNA damage by regulating the p53, Fanconi anemia, and oxidative stress repair pathways through transcriptional or non-transcriptional mechanisms. This review highlights the importance of RUNX-dependent DNA repair regulation in human cancers.
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spelling pubmed-101368742023-04-28 The RUNX Family of Proteins, DNA Repair, and Cancer Krishnan, Vaidehi Cells Review The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer. Emerging evidence suggests that the dysregulation of RUNX genes can promote genomic instability in both leukemia and solid cancers by impairing DNA repair mechanisms. RUNX proteins control the cellular response to DNA damage by regulating the p53, Fanconi anemia, and oxidative stress repair pathways through transcriptional or non-transcriptional mechanisms. This review highlights the importance of RUNX-dependent DNA repair regulation in human cancers. MDPI 2023-04-07 /pmc/articles/PMC10136874/ /pubmed/37190015 http://dx.doi.org/10.3390/cells12081106 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Krishnan, Vaidehi
The RUNX Family of Proteins, DNA Repair, and Cancer
title The RUNX Family of Proteins, DNA Repair, and Cancer
title_full The RUNX Family of Proteins, DNA Repair, and Cancer
title_fullStr The RUNX Family of Proteins, DNA Repair, and Cancer
title_full_unstemmed The RUNX Family of Proteins, DNA Repair, and Cancer
title_short The RUNX Family of Proteins, DNA Repair, and Cancer
title_sort runx family of proteins, dna repair, and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136874/
https://www.ncbi.nlm.nih.gov/pubmed/37190015
http://dx.doi.org/10.3390/cells12081106
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