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A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience

Background: There is limited information regarding the immunohistochemistry stain and its prognostic role in adrenocortical carcinoma (ACC), and few studies focus on Asian patients. Our study aims to identify the correlation between immunohistochemistry staining and the prognosis of ACC in Asian pat...

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Autores principales: Tsai, Wen-Hsuan, Dai, Shuen-Han, Lee, Chun-Chuan, Chien, Ming-Nan, Zeng, Yi-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136886/
https://www.ncbi.nlm.nih.gov/pubmed/37185426
http://dx.doi.org/10.3390/curroncol30040313
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author Tsai, Wen-Hsuan
Dai, Shuen-Han
Lee, Chun-Chuan
Chien, Ming-Nan
Zeng, Yi-Hong
author_facet Tsai, Wen-Hsuan
Dai, Shuen-Han
Lee, Chun-Chuan
Chien, Ming-Nan
Zeng, Yi-Hong
author_sort Tsai, Wen-Hsuan
collection PubMed
description Background: There is limited information regarding the immunohistochemistry stain and its prognostic role in adrenocortical carcinoma (ACC), and few studies focus on Asian patients. Our study aims to identify the correlation between immunohistochemistry staining and the prognosis of ACC in Asian patients. Methods: We searched the database of a single center in Taiwan for cases with a pathological diagnosis of ACC in the past 25 years. We collected patient data on age, sex, initial presentation, staging, metastatic site, and survival duration. Immunohistochemical studies using antibodies to CDK4, ATRX, beta-catenin, Ki-67, SSTR2, and p53 were performed. Survival analysis was performed using the log-rank test, the Cox proportional hazards model and bootstrapping with 5000 samplings. Results: Fourteen patients were identified, and the median age was 49.5 (range 1–70) years. There were eight male and six female patients. Four patients presented with Cushing’s syndrome, and half were diagnosed with stage IV ACC at presentation. Only three patients survived (21%). The median survival time was 15.5 (range 0.67–244) months. SSTR2 expression score > 50 (log-rank test: p = 0.009) and Ki-67 > 50% (log-rank test: p = 0.017) were associated with mortality. However, after adjusting for stage, the bootstrapping analysis demonstrated that Ki-67 [B 2.04, p = 0.004], Beta-catenin [B 2.19, p = 0.009], ATRX [B 1.48, p = 0.026], P53 [B 1.58, p = 0.027], SSTR2 [B 1.58, p = 0.015] and SSTR2 expression score [B 0.03, p < 0.001] were all significantly associated with mortality. Conclusions: After adjusting for stage, Ki-67 > 50%, Beta-catenin, ATRX, P53, SSTR2 and SSTR2 expression score > 50 were associated with mortality in Asian patients with ACC.
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spelling pubmed-101368862023-04-28 A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience Tsai, Wen-Hsuan Dai, Shuen-Han Lee, Chun-Chuan Chien, Ming-Nan Zeng, Yi-Hong Curr Oncol Communication Background: There is limited information regarding the immunohistochemistry stain and its prognostic role in adrenocortical carcinoma (ACC), and few studies focus on Asian patients. Our study aims to identify the correlation between immunohistochemistry staining and the prognosis of ACC in Asian patients. Methods: We searched the database of a single center in Taiwan for cases with a pathological diagnosis of ACC in the past 25 years. We collected patient data on age, sex, initial presentation, staging, metastatic site, and survival duration. Immunohistochemical studies using antibodies to CDK4, ATRX, beta-catenin, Ki-67, SSTR2, and p53 were performed. Survival analysis was performed using the log-rank test, the Cox proportional hazards model and bootstrapping with 5000 samplings. Results: Fourteen patients were identified, and the median age was 49.5 (range 1–70) years. There were eight male and six female patients. Four patients presented with Cushing’s syndrome, and half were diagnosed with stage IV ACC at presentation. Only three patients survived (21%). The median survival time was 15.5 (range 0.67–244) months. SSTR2 expression score > 50 (log-rank test: p = 0.009) and Ki-67 > 50% (log-rank test: p = 0.017) were associated with mortality. However, after adjusting for stage, the bootstrapping analysis demonstrated that Ki-67 [B 2.04, p = 0.004], Beta-catenin [B 2.19, p = 0.009], ATRX [B 1.48, p = 0.026], P53 [B 1.58, p = 0.027], SSTR2 [B 1.58, p = 0.015] and SSTR2 expression score [B 0.03, p < 0.001] were all significantly associated with mortality. Conclusions: After adjusting for stage, Ki-67 > 50%, Beta-catenin, ATRX, P53, SSTR2 and SSTR2 expression score > 50 were associated with mortality in Asian patients with ACC. MDPI 2023-04-08 /pmc/articles/PMC10136886/ /pubmed/37185426 http://dx.doi.org/10.3390/curroncol30040313 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Tsai, Wen-Hsuan
Dai, Shuen-Han
Lee, Chun-Chuan
Chien, Ming-Nan
Zeng, Yi-Hong
A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience
title A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience
title_full A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience
title_fullStr A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience
title_full_unstemmed A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience
title_short A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience
title_sort clinicopathological analysis of asian patients with adrenocortical carcinoma: a single-center experience
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136886/
https://www.ncbi.nlm.nih.gov/pubmed/37185426
http://dx.doi.org/10.3390/curroncol30040313
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