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A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience
Background: There is limited information regarding the immunohistochemistry stain and its prognostic role in adrenocortical carcinoma (ACC), and few studies focus on Asian patients. Our study aims to identify the correlation between immunohistochemistry staining and the prognosis of ACC in Asian pat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136886/ https://www.ncbi.nlm.nih.gov/pubmed/37185426 http://dx.doi.org/10.3390/curroncol30040313 |
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author | Tsai, Wen-Hsuan Dai, Shuen-Han Lee, Chun-Chuan Chien, Ming-Nan Zeng, Yi-Hong |
author_facet | Tsai, Wen-Hsuan Dai, Shuen-Han Lee, Chun-Chuan Chien, Ming-Nan Zeng, Yi-Hong |
author_sort | Tsai, Wen-Hsuan |
collection | PubMed |
description | Background: There is limited information regarding the immunohistochemistry stain and its prognostic role in adrenocortical carcinoma (ACC), and few studies focus on Asian patients. Our study aims to identify the correlation between immunohistochemistry staining and the prognosis of ACC in Asian patients. Methods: We searched the database of a single center in Taiwan for cases with a pathological diagnosis of ACC in the past 25 years. We collected patient data on age, sex, initial presentation, staging, metastatic site, and survival duration. Immunohistochemical studies using antibodies to CDK4, ATRX, beta-catenin, Ki-67, SSTR2, and p53 were performed. Survival analysis was performed using the log-rank test, the Cox proportional hazards model and bootstrapping with 5000 samplings. Results: Fourteen patients were identified, and the median age was 49.5 (range 1–70) years. There were eight male and six female patients. Four patients presented with Cushing’s syndrome, and half were diagnosed with stage IV ACC at presentation. Only three patients survived (21%). The median survival time was 15.5 (range 0.67–244) months. SSTR2 expression score > 50 (log-rank test: p = 0.009) and Ki-67 > 50% (log-rank test: p = 0.017) were associated with mortality. However, after adjusting for stage, the bootstrapping analysis demonstrated that Ki-67 [B 2.04, p = 0.004], Beta-catenin [B 2.19, p = 0.009], ATRX [B 1.48, p = 0.026], P53 [B 1.58, p = 0.027], SSTR2 [B 1.58, p = 0.015] and SSTR2 expression score [B 0.03, p < 0.001] were all significantly associated with mortality. Conclusions: After adjusting for stage, Ki-67 > 50%, Beta-catenin, ATRX, P53, SSTR2 and SSTR2 expression score > 50 were associated with mortality in Asian patients with ACC. |
format | Online Article Text |
id | pubmed-10136886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101368862023-04-28 A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience Tsai, Wen-Hsuan Dai, Shuen-Han Lee, Chun-Chuan Chien, Ming-Nan Zeng, Yi-Hong Curr Oncol Communication Background: There is limited information regarding the immunohistochemistry stain and its prognostic role in adrenocortical carcinoma (ACC), and few studies focus on Asian patients. Our study aims to identify the correlation between immunohistochemistry staining and the prognosis of ACC in Asian patients. Methods: We searched the database of a single center in Taiwan for cases with a pathological diagnosis of ACC in the past 25 years. We collected patient data on age, sex, initial presentation, staging, metastatic site, and survival duration. Immunohistochemical studies using antibodies to CDK4, ATRX, beta-catenin, Ki-67, SSTR2, and p53 were performed. Survival analysis was performed using the log-rank test, the Cox proportional hazards model and bootstrapping with 5000 samplings. Results: Fourteen patients were identified, and the median age was 49.5 (range 1–70) years. There were eight male and six female patients. Four patients presented with Cushing’s syndrome, and half were diagnosed with stage IV ACC at presentation. Only three patients survived (21%). The median survival time was 15.5 (range 0.67–244) months. SSTR2 expression score > 50 (log-rank test: p = 0.009) and Ki-67 > 50% (log-rank test: p = 0.017) were associated with mortality. However, after adjusting for stage, the bootstrapping analysis demonstrated that Ki-67 [B 2.04, p = 0.004], Beta-catenin [B 2.19, p = 0.009], ATRX [B 1.48, p = 0.026], P53 [B 1.58, p = 0.027], SSTR2 [B 1.58, p = 0.015] and SSTR2 expression score [B 0.03, p < 0.001] were all significantly associated with mortality. Conclusions: After adjusting for stage, Ki-67 > 50%, Beta-catenin, ATRX, P53, SSTR2 and SSTR2 expression score > 50 were associated with mortality in Asian patients with ACC. MDPI 2023-04-08 /pmc/articles/PMC10136886/ /pubmed/37185426 http://dx.doi.org/10.3390/curroncol30040313 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Tsai, Wen-Hsuan Dai, Shuen-Han Lee, Chun-Chuan Chien, Ming-Nan Zeng, Yi-Hong A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience |
title | A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience |
title_full | A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience |
title_fullStr | A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience |
title_full_unstemmed | A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience |
title_short | A Clinicopathological Analysis of Asian Patients with Adrenocortical Carcinoma: A Single-Center Experience |
title_sort | clinicopathological analysis of asian patients with adrenocortical carcinoma: a single-center experience |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136886/ https://www.ncbi.nlm.nih.gov/pubmed/37185426 http://dx.doi.org/10.3390/curroncol30040313 |
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