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A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies
Vitamin D deficiency has been correlated with various conditions, including the risk of developing lymphoid malignancies. This systematic review aimed to assess the association between vitamin D levels at diagnosis of lymphoid malignancies, patient outcomes, and survival. A systematic review was con...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137018/ https://www.ncbi.nlm.nih.gov/pubmed/37185444 http://dx.doi.org/10.3390/curroncol30040331 |
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author | Potre, Cristina Borsi, Ema Potre, Ovidiu Ionita, Ioana Samfireag, Miruna Costachescu, Dan Secosan, Cristina Lazar, Sandra Ristescu, Anca Irina |
author_facet | Potre, Cristina Borsi, Ema Potre, Ovidiu Ionita, Ioana Samfireag, Miruna Costachescu, Dan Secosan, Cristina Lazar, Sandra Ristescu, Anca Irina |
author_sort | Potre, Cristina |
collection | PubMed |
description | Vitamin D deficiency has been correlated with various conditions, including the risk of developing lymphoid malignancies. This systematic review aimed to assess the association between vitamin D levels at diagnosis of lymphoid malignancies, patient outcomes, and survival. A systematic review was conducted, encompassing 15 studies published until January 2023, involving 4503 patients, examining the relationship between vitamin D and lymphoid cancers. The median age of the patients was 56.5 years, with a median follow-up duration of approximately 36 months across studies. The overall median vitamin D level at initial measurement was 20.4 ng/mL, while a <20 ng/mL threshold was used to define vitamin D insufficiency. The results demonstrated significant associations between vitamin D levels and patient outcomes in several lymphoid malignancies, with a pooled risk in disease progression of 1.93 and a pooled hazard ratio of 2.06 for overall survival in patients with 25-(OH)D levels below the normal threshold of 20 ng/mL. Among findings, it was demonstrated that supplemental vitamin D improves the chemosensitivity of tumors by reducing the rate of tumor growth compared with vitamin D or chemotherapy alone. Vitamin D had a protective effect for patients with DLBCL under R-CHOP treatment, while vitamin D insufficiency was associated with the impairment of rituximab treatment and showed worse clinical outcomes in chimeric antigen receptor T-cell (CAR-T) recipients. Although one study found no association between vitamin D deficiency and the cause of death, most associated vitamin D insufficiency with early clinical failure and lower survival probability. In conclusion, his systematic review highlights the importance of vitamin D levels in the prognosis and survival of patients with lymphoid malignancies. Further research is needed to better understand the underlying mechanisms and explore the potential benefits of vitamin D supplementation in managing these cancers. |
format | Online Article Text |
id | pubmed-10137018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101370182023-04-28 A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies Potre, Cristina Borsi, Ema Potre, Ovidiu Ionita, Ioana Samfireag, Miruna Costachescu, Dan Secosan, Cristina Lazar, Sandra Ristescu, Anca Irina Curr Oncol Systematic Review Vitamin D deficiency has been correlated with various conditions, including the risk of developing lymphoid malignancies. This systematic review aimed to assess the association between vitamin D levels at diagnosis of lymphoid malignancies, patient outcomes, and survival. A systematic review was conducted, encompassing 15 studies published until January 2023, involving 4503 patients, examining the relationship between vitamin D and lymphoid cancers. The median age of the patients was 56.5 years, with a median follow-up duration of approximately 36 months across studies. The overall median vitamin D level at initial measurement was 20.4 ng/mL, while a <20 ng/mL threshold was used to define vitamin D insufficiency. The results demonstrated significant associations between vitamin D levels and patient outcomes in several lymphoid malignancies, with a pooled risk in disease progression of 1.93 and a pooled hazard ratio of 2.06 for overall survival in patients with 25-(OH)D levels below the normal threshold of 20 ng/mL. Among findings, it was demonstrated that supplemental vitamin D improves the chemosensitivity of tumors by reducing the rate of tumor growth compared with vitamin D or chemotherapy alone. Vitamin D had a protective effect for patients with DLBCL under R-CHOP treatment, while vitamin D insufficiency was associated with the impairment of rituximab treatment and showed worse clinical outcomes in chimeric antigen receptor T-cell (CAR-T) recipients. Although one study found no association between vitamin D deficiency and the cause of death, most associated vitamin D insufficiency with early clinical failure and lower survival probability. In conclusion, his systematic review highlights the importance of vitamin D levels in the prognosis and survival of patients with lymphoid malignancies. Further research is needed to better understand the underlying mechanisms and explore the potential benefits of vitamin D supplementation in managing these cancers. MDPI 2023-04-20 /pmc/articles/PMC10137018/ /pubmed/37185444 http://dx.doi.org/10.3390/curroncol30040331 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Systematic Review Potre, Cristina Borsi, Ema Potre, Ovidiu Ionita, Ioana Samfireag, Miruna Costachescu, Dan Secosan, Cristina Lazar, Sandra Ristescu, Anca Irina A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies |
title | A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies |
title_full | A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies |
title_fullStr | A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies |
title_full_unstemmed | A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies |
title_short | A Systematic Review Assessing the Impact of Vitamin D Levels on Adult Patients with Lymphoid Malignancies |
title_sort | systematic review assessing the impact of vitamin d levels on adult patients with lymphoid malignancies |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137018/ https://www.ncbi.nlm.nih.gov/pubmed/37185444 http://dx.doi.org/10.3390/curroncol30040331 |
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