Epigenetic Modifications in Prostate Cancer Metastasis and Microenvironment

SIMPLE SUMMARY: Epigenetics, which leads to specific differentiation events and determines gene expression states, has been recognized as a developmental landscape. Epigenetic modifications are widespread in mammals. Dysregulation of epigenetic modifications is closely related to the occurrence of diseases, especially cancer. The relationship between epigenetic modification and cancer has been widely studied. This review aims to summarize the different epigenetic modifications events that occur in prostate cancer and improve our understanding of the biological role of epigenetic modifications in prostate cancer metastasis. ABSTRACT: The gradual evolution of prostate tissue from benign tumor to malignant lesion or distant metastasis is driven by intracellular epigenetic changes and the tumor microenvironment remodeling. With the continuous study of epigenetic modifications, these tumor-driving forces are being discovered and are providing new treatments for cancer. Here we introduce the classification of epigenetic modification and highlight the role of epigenetic modification in tumor remodeling and communication of the tumor microenvironment.