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Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study

Background: Congenital abdominal wall defects might be associated with other anomalies, such as atresia in gastroschisis and cardiac anomalies in omphalocele patients. However, in the current literature, an overview of these additional anomalies and potential patient-specific risk factors is missing...

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Autores principales: Pijpers, Adinda G. H., de Beaufort, Cunera M. C., Maat, Sanne C., Broers, Chantal J. M., Straver, Bart, van Heurn, Ernest, Gorter, Ramon R., Derikx, Joep P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137210/
https://www.ncbi.nlm.nih.gov/pubmed/37189937
http://dx.doi.org/10.3390/children10040688
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author Pijpers, Adinda G. H.
de Beaufort, Cunera M. C.
Maat, Sanne C.
Broers, Chantal J. M.
Straver, Bart
van Heurn, Ernest
Gorter, Ramon R.
Derikx, Joep P. M.
author_facet Pijpers, Adinda G. H.
de Beaufort, Cunera M. C.
Maat, Sanne C.
Broers, Chantal J. M.
Straver, Bart
van Heurn, Ernest
Gorter, Ramon R.
Derikx, Joep P. M.
author_sort Pijpers, Adinda G. H.
collection PubMed
description Background: Congenital abdominal wall defects might be associated with other anomalies, such as atresia in gastroschisis and cardiac anomalies in omphalocele patients. However, in the current literature, an overview of these additional anomalies and potential patient-specific risk factors is missing. Therefore, we aimed to assess the prevalence of associated anomalies and their patient-specific risk factors in patients with gastroschisis and omphalocele. Methods: A mono-center retrospective cohort study between 1997 and 2023 was performed. Outcomes were the presence of any additional anomalies. Risk factors were analyzed via logistic regression analysis. Results: In total, 122 patients were included, of whom 82 (67.2%) had gastroschisis, and 40 (32.8%) had omphalocele. Additional anomalies were identified in 26 gastroschisis patients (31.7%) and in 27 omphalocele patients (67.5%). In patients with gastroschisis, intestinal anomalies were most identified (n = 13, 15.9%), whereas, in patients with omphalocele, cardiac anomalies were most identified (n = 15, 37.5%). Logistic regression showed that cardiac anomalies were associated with complex gastroschisis (OR: 8.5; CI-95%: 1.4–49.5). Conclusions: In patients with gastroschisis and omphalocele, intestinal and cardiac anomalies were most identified, respectively. Cardiac anomalies were found to be a risk factor for patients with complex gastroschisis. Therefore, regardless of the type of gastroschisis and/or omphalocele, postnatal cardiac screening remains important.
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spelling pubmed-101372102023-04-28 Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study Pijpers, Adinda G. H. de Beaufort, Cunera M. C. Maat, Sanne C. Broers, Chantal J. M. Straver, Bart van Heurn, Ernest Gorter, Ramon R. Derikx, Joep P. M. Children (Basel) Article Background: Congenital abdominal wall defects might be associated with other anomalies, such as atresia in gastroschisis and cardiac anomalies in omphalocele patients. However, in the current literature, an overview of these additional anomalies and potential patient-specific risk factors is missing. Therefore, we aimed to assess the prevalence of associated anomalies and their patient-specific risk factors in patients with gastroschisis and omphalocele. Methods: A mono-center retrospective cohort study between 1997 and 2023 was performed. Outcomes were the presence of any additional anomalies. Risk factors were analyzed via logistic regression analysis. Results: In total, 122 patients were included, of whom 82 (67.2%) had gastroschisis, and 40 (32.8%) had omphalocele. Additional anomalies were identified in 26 gastroschisis patients (31.7%) and in 27 omphalocele patients (67.5%). In patients with gastroschisis, intestinal anomalies were most identified (n = 13, 15.9%), whereas, in patients with omphalocele, cardiac anomalies were most identified (n = 15, 37.5%). Logistic regression showed that cardiac anomalies were associated with complex gastroschisis (OR: 8.5; CI-95%: 1.4–49.5). Conclusions: In patients with gastroschisis and omphalocele, intestinal and cardiac anomalies were most identified, respectively. Cardiac anomalies were found to be a risk factor for patients with complex gastroschisis. Therefore, regardless of the type of gastroschisis and/or omphalocele, postnatal cardiac screening remains important. MDPI 2023-04-05 /pmc/articles/PMC10137210/ /pubmed/37189937 http://dx.doi.org/10.3390/children10040688 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pijpers, Adinda G. H.
de Beaufort, Cunera M. C.
Maat, Sanne C.
Broers, Chantal J. M.
Straver, Bart
van Heurn, Ernest
Gorter, Ramon R.
Derikx, Joep P. M.
Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study
title Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study
title_full Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study
title_fullStr Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study
title_full_unstemmed Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study
title_short Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study
title_sort additional anomalies in children with gastroschisis and omphalocele: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137210/
https://www.ncbi.nlm.nih.gov/pubmed/37189937
http://dx.doi.org/10.3390/children10040688
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