Cargando…

Omphalocele and Cardiac Abnormalities—The Importance of the Association

Omphalocele is the most common ventral abdominal wall defect. Omphalocele is associated with other significant anomalies in up to 80% of cases, among which the cardiac ones are the most frequent. The aim of our paper is to highlight, through a review of the literature, the importance and frequency o...

Descripción completa

Detalles Bibliográficos
Autores principales: Țarcă, Elena, Al Namat, Dina, Luca, Alina Costina, Lupu, Vasile Valeriu, Al Namat, Razan, Lupu, Ancuța, Bălănescu, Laura, Bernic, Jana, Butnariu, Lăcrămioara Ionela, Moscalu, Mihaela, Hînganu, Marius Valeriu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137326/
https://www.ncbi.nlm.nih.gov/pubmed/37189514
http://dx.doi.org/10.3390/diagnostics13081413
_version_ 1785032435903234048
author Țarcă, Elena
Al Namat, Dina
Luca, Alina Costina
Lupu, Vasile Valeriu
Al Namat, Razan
Lupu, Ancuța
Bălănescu, Laura
Bernic, Jana
Butnariu, Lăcrămioara Ionela
Moscalu, Mihaela
Hînganu, Marius Valeriu
author_facet Țarcă, Elena
Al Namat, Dina
Luca, Alina Costina
Lupu, Vasile Valeriu
Al Namat, Razan
Lupu, Ancuța
Bălănescu, Laura
Bernic, Jana
Butnariu, Lăcrămioara Ionela
Moscalu, Mihaela
Hînganu, Marius Valeriu
author_sort Țarcă, Elena
collection PubMed
description Omphalocele is the most common ventral abdominal wall defect. Omphalocele is associated with other significant anomalies in up to 80% of cases, among which the cardiac ones are the most frequent. The aim of our paper is to highlight, through a review of the literature, the importance and frequency of association between the two malformations and what impact this association has on the management and evolution of patients with these pathologies. We reviewed the titles, the available abstracts, and the full texts of 244 papers from the last 23 years, from three medical databases, to extract data for our review. Due to the frequent association of the two malformations and the unfavorable effect of the major cardiac anomaly on the prognosis of the newborn, the electrocardiogram and echocardiography must be included in the first postnatal investigations. The timing of surgery for abdominal wall defect closure is mostly dictated by the cardiac defect severity, and usually the cardiac defect takes priority. After the cardiac defect is medically stabilized or surgically repaired, the omphalocele reduction and closure of the abdominal defect are performed in a more controlled setting, with improved outcomes. Compared to omphalocele patients without cardiac defects, children with this association are more likely to experience prolonged hospitalizations, neurologic, and cognitive impairments. Major cardiac abnormalities such as structural defects that require surgical treatment or result in developmental delay will significantly increase the death rate of patients with omphalocele. In conclusion, the prenatal diagnosis of omphalocele and early detection of other associated structural or chromosomal anomalies are of overwhelming importance, contributing to the establishment of antenatal and postnatal prognosis.
format Online
Article
Text
id pubmed-10137326
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101373262023-04-28 Omphalocele and Cardiac Abnormalities—The Importance of the Association Țarcă, Elena Al Namat, Dina Luca, Alina Costina Lupu, Vasile Valeriu Al Namat, Razan Lupu, Ancuța Bălănescu, Laura Bernic, Jana Butnariu, Lăcrămioara Ionela Moscalu, Mihaela Hînganu, Marius Valeriu Diagnostics (Basel) Review Omphalocele is the most common ventral abdominal wall defect. Omphalocele is associated with other significant anomalies in up to 80% of cases, among which the cardiac ones are the most frequent. The aim of our paper is to highlight, through a review of the literature, the importance and frequency of association between the two malformations and what impact this association has on the management and evolution of patients with these pathologies. We reviewed the titles, the available abstracts, and the full texts of 244 papers from the last 23 years, from three medical databases, to extract data for our review. Due to the frequent association of the two malformations and the unfavorable effect of the major cardiac anomaly on the prognosis of the newborn, the electrocardiogram and echocardiography must be included in the first postnatal investigations. The timing of surgery for abdominal wall defect closure is mostly dictated by the cardiac defect severity, and usually the cardiac defect takes priority. After the cardiac defect is medically stabilized or surgically repaired, the omphalocele reduction and closure of the abdominal defect are performed in a more controlled setting, with improved outcomes. Compared to omphalocele patients without cardiac defects, children with this association are more likely to experience prolonged hospitalizations, neurologic, and cognitive impairments. Major cardiac abnormalities such as structural defects that require surgical treatment or result in developmental delay will significantly increase the death rate of patients with omphalocele. In conclusion, the prenatal diagnosis of omphalocele and early detection of other associated structural or chromosomal anomalies are of overwhelming importance, contributing to the establishment of antenatal and postnatal prognosis. MDPI 2023-04-14 /pmc/articles/PMC10137326/ /pubmed/37189514 http://dx.doi.org/10.3390/diagnostics13081413 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Țarcă, Elena
Al Namat, Dina
Luca, Alina Costina
Lupu, Vasile Valeriu
Al Namat, Razan
Lupu, Ancuța
Bălănescu, Laura
Bernic, Jana
Butnariu, Lăcrămioara Ionela
Moscalu, Mihaela
Hînganu, Marius Valeriu
Omphalocele and Cardiac Abnormalities—The Importance of the Association
title Omphalocele and Cardiac Abnormalities—The Importance of the Association
title_full Omphalocele and Cardiac Abnormalities—The Importance of the Association
title_fullStr Omphalocele and Cardiac Abnormalities—The Importance of the Association
title_full_unstemmed Omphalocele and Cardiac Abnormalities—The Importance of the Association
title_short Omphalocele and Cardiac Abnormalities—The Importance of the Association
title_sort omphalocele and cardiac abnormalities—the importance of the association
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137326/
https://www.ncbi.nlm.nih.gov/pubmed/37189514
http://dx.doi.org/10.3390/diagnostics13081413
work_keys_str_mv AT tarcaelena omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT alnamatdina omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT lucaalinacostina omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT lupuvasilevaleriu omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT alnamatrazan omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT lupuancuta omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT balanesculaura omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT bernicjana omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT butnariulacramioaraionela omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT moscalumihaela omphaloceleandcardiacabnormalitiestheimportanceoftheassociation
AT hinganumariusvaleriu omphaloceleandcardiacabnormalitiestheimportanceoftheassociation